Abstract:
:GAW10 Problem 2 involves a simulated common disease defined by imposing a threshold, T, on a quantitative trait, Q1. Every individual with a value of Q1 > or = T (where T = 40) is defined as affected. Also thought to be associated with the disease as intervening variables are four other quantitative traits (Q2, Q3, Q4, and Q5) and an environmental factor (EF). Each individual has genotypes for 367 highly polymorphic markers on 10 chromosomes. The tasks for GAW10 were to characterize the genetic and environmental contribution to Q1 (and the disease), Q2, Q3, Q4, and Q5, and to localize any single genes that have detectable effects. Multiple replicates provided an opportunity to address questions of power and false positive rates.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
MacCluer JW,Blangero J,Dyer TD,Speer MCdoi
10.1002/(SICI)1098-2272(1997)14:6<737::AID-GEPI29>subject
Has Abstractpub_date
1997-01-01 00:00:00pages
737-42issue
6eissn
0741-0395issn
1098-2272pii
10.1002/(SICI)1098-2272(1997)14:6<737::AID-GEPI29>journal_volume
14pub_type
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