Abstract:
:We have conducted a study of renal sodium and potassium reabsorption in 205 pairs of twins on freely chosen diets; 89 of the subjects were studied on more than one occasion. Renal tubular sodium and potassium handling, as measured by the fractional excretions FENa and FEK, show repeatable differences between individuals. Siblings (in this case monozygotic and dizygotic pairs of twins) are more alike in this respect than unrelated individuals. Comparison of monozygotic and dizygotic twin pairs indicates that genetic, rather than shared environmental, factors are probably responsible for this similarity, with heritability estimates of 0.5 for sodium and 0.6 for potassium. There are indications of sex differences in the sizes of the genetic and environmental effects for both variables and indications that the genetic effects may be qualitatively different for FEK. Such findings need further investigation.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Whitfield JB,Martin NGdoi
10.1002/gepi.1370020103subject
Has Abstractpub_date
1985-01-01 00:00:00pages
17-27issue
1eissn
0741-0395issn
1098-2272journal_volume
2pub_type
杂志文章abstract::Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a disorder that has an elevated frequency in Saguenay-Lac-St-Jean (SLSJ) and Charlevoix, two geographically isolated regions in the past of northeastern Quebec. The incidence at birth and the carrier rate in SLSJ were estimated at 1/1,932 liveborn i...
journal_title:Genetic epidemiology
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doi:10.1002/gepi.1370100103
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370090305
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21646
更新日期:2012-07-01 00:00:00
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更新日期:2015-02-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21746
更新日期:2013-09-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20036
更新日期:2005-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s204
更新日期:2001-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21645
更新日期:2012-09-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20650
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370050409
更新日期:1988-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.10319
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370030403
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pub_type: 杂志文章
doi:10.1002/gepi.1370170738
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20182
更新日期:2006-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.22337
更新日期:2020-10-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20158
更新日期:2006-07-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1997)14:6<797::AID-GEPI39>
更新日期:1997-01-01 00:00:00