Abstract:
:We propose methods to construct meiotic gene maps while controlling the probability of a decision-error. First, a single step gene ordering procedure is presented whose decision-error probability is bounded above by a prespecified threshold. The bound for the error probability is valid under quite general circumstances. The ordering procedure is optimal in the sense of having maximal predictive probability of correct ordering among all procedures subject to the same bound on the error probability. Second, to reduce the number of hypotheses to be tested, a stepwise ordering procedure is presented. A Monte Carlo simulation study demonstrated the integrity of the proposed error bound for the stepwise procedure under a wide variety of situations, including data coming from different laboratories and marker typing errors. The stepwise procedure was applied to version 2 of the public database maintained by the Cooperative Human Linkage Center and maps of the 23 chromosomes were generated such that the probability that the order of the markers in a given chromosome is incorrect is less than 1%.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Rogatko A,Babb J,Jordan H,Zacks Sdoi
10.1002/(SICI)1098-2272(1999)16:3<274::AID-GEPI4>3subject
Has Abstractpub_date
1999-01-01 00:00:00pages
274-89issue
3eissn
0741-0395issn
1098-2272pii
10.1002/(SICI)1098-2272(1999)16:3<274::AID-GEPI4>3journal_volume
16pub_type
杂志文章abstract::Path analysis of nuclear family data has been widely applied to resolve genetic and environmental sources of familial resemblance. Here we report the results of a systematic evaluation of the effects of departures from five modeling assumptions often made when analyzing nuclear family data; i) the observed environment...
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1996)13:3<285::AID-GEPI5>3
更新日期:1996-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21628
更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20246
更新日期:2007-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370040603
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370060404
更新日期:1989-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章,评审
doi:10.1002/gepi.1370060111
更新日期:1989-01-01 00:00:00
abstract::This study is an investigation of the relationship between apolipoprotein E (apoE) phenotype, arterial disease, and mortality in a group of women (n = 1,751) aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Crude mortality rates were highest among women with the 4-3 and 4-4 phenotypes but age-a...
journal_title:Genetic epidemiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/(SICI)1098-2272(1997)14:2<147::AID-GEPI4>3
更新日期:1997-01-01 00:00:00
abstract::We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the popula...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370120623
更新日期:1995-01-01 00:00:00
abstract::Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s312
更新日期:2001-01-01 00:00:00
abstract::The prevalence rate for autoimmune thyroid disease (ATD) is about 30 times higher in the type I diabetic (IDDM) families that were ascertained for Genetic Analysis Workshop 5 (GAW5) than in the general population. Two approaches were used to study the clustering of ATD and IDDM in these families: 1) HLA haplotype shar...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370060126
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370090305
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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doi:10.1002/gepi.22191
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doi:10.1002/gepi.2001.21.s1.s204
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.22358
更新日期:2021-02-01 00:00:00
abstract::Genome-wide association studies are proven tools for finding disease genes, but it is often necessary to combine many cohorts into a meta-analysis to detect statistically significant genetic effects. Often the component studies are performed by different investigators on different populations, using different chips wi...
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pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.13701707128
更新日期:1999-01-01 00:00:00
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更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
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