Abstract:
:This study is an investigation of the relationship between apolipoprotein E (apoE) phenotype, arterial disease, and mortality in a group of women (n = 1,751) aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Crude mortality rates were highest among women with the 4-3 and 4-4 phenotypes but age-adjusted mortality showed no statistically significant variations across the phenotype groups. Using multivariate analysis, the mortality experience of women with 4-3 or 4-4 apoE phenotypes was compared to that of women with the 3-3 phenotype: no significant excess total mortality was found [relative risk (RR) = 1.2, 95% confidence interval (CI) 0.8, 1.8] among women with the epsilon 4 allele. Similarly, neither cardiovascular (RR = 0.9. 95% CI 0.5, 1.8) nor cancer (RR = 1.5, 95% CI 0.8, 2.8) mortality rates were significantly different in this group of women. Inclusion of cholesterol levels in the regression models did not change the relative mortality risks. Among women 65-69 year of age epsilon 4 was associated with an approximate doubling of RR for death due to both cardiovascular disease and cancer. No association was found between apoE phenotype and the presence of lower extremity arterial disease (defined as an ankle/arm index of 0.9 or less). These results suggest that women with the epsilon 4 who survive to age 70 years or beyond have a life expectancy that is similar to that for women homozygous for the 3 allele who comprise the majority of the population.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Vogt MT,Cauley JA,Kuller LHdoi
10.1002/(SICI)1098-2272(1997)14:2<147::AID-GEPI4>3subject
Has Abstractpub_date
1997-01-01 00:00:00pages
147-56issue
2eissn
0741-0395issn
1098-2272pii
10.1002/(SICI)1098-2272(1997)14:2<147::AID-GEPI4>3journal_volume
14pub_type
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doi:10.1002/gepi.20221
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更新日期:2017-07-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Genetic epidemiology
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.22083
更新日期:2017-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1997)14:6<797::AID-GEPI39>
更新日期:1997-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370010105
更新日期:1984-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370100618
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.20321
更新日期:2008-07-01 00:00:00
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journal_title:Genetic epidemiology
pub_type:
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更新日期:2000-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Genetic epidemiology
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