Abstract:
:The extended transmission disequilibrium test (ETDT) of Sham and Curtis [1995] is a powerful test of the null hypothesis of no linkage between a multi-allelic marker locus and a disease susceptibility locus of unknown location in the presence of association between alleles at the two loci. We propose a generalization of the ETDT to test simultaneously for linkage of markers to two unlinked disease loci. Analysis of the simulated data for Problem 2 would suggest improvements in power to detect linkage to pairs of disease loci over single locus tests. This is as a result of the two locus model taking account of epistasis between the disease loci.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Morris A,Whittaker Jdoi
10.1002/gepi.13701707108subject
Has Abstractpub_date
1999-01-01 00:00:00pages
S661-6eissn
0741-0395issn
1098-2272journal_volume
17 Suppl 1pub_type
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