Abstract:
:We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Tiwari HK,Zhu X,Elston RC,Shu Y,George Vdoi
10.1002/gepi.1370170758subject
Has Abstractpub_date
1999-01-01 00:00:00pages
S343-7eissn
0741-0395issn
1098-2272journal_volume
17 Suppl 1pub_type
杂志文章abstract::Increased adiposity has repeatedly been identified as a major risk factor for a variety of chronic diseases. However, the question still remains whether the amount of adipose tissue itself is genetically mediated. To address this question, a segregation analysis, using maximum likelihood techniques as implemented in t...
journal_title:Genetic epidemiology
pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1996)13:1<79::AID-GEPI7>3.
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abstract::We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis under two models of ascert...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370120613
更新日期:1995-01-01 00:00:00
abstract::Imputation is widely used for obtaining information about rare variants. However, one issue concerning imputation is the low accuracy of imputed rare variants as the inaccurate imputed rare variants may distort the results of region-based association tests. Therefore, we developed a pre-collapsing imputation method (P...
journal_title:Genetic epidemiology
pub_type: 杂志文章,多中心研究
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abstract::This paper discusses the theory and implementation of a model for mapping X-linked quantitative trait loci (QTL). As a result of X inactivation, a female's body is subdivided into a number of patches. In each patch one of her two X chromosomes is randomly switched off. This smooths the allelic contributions in a heter...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20158
更新日期:2006-07-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20626
更新日期:2011-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1999)16:1<95::AID-GEPI8>3.
更新日期:1999-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370120623
更新日期:1995-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370060404
更新日期:1989-01-01 00:00:00
abstract::Two analytic methods were used in the Problem 2 data set. First, generalized estimating equations (GEE) modelling was developed to adjust for familial correlation in regressions evaluating candidate genes and an environmental factor. Second, the affected-pedigree-member (APM) method was used to identify chromosomal re...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370120633
更新日期:1995-01-01 00:00:00
abstract::We have conducted a simulation study in small pedigrees to investigate the power to detect linkage and heterogeneity for a disorder due to either one of two independent disease loci. We have considered a highly polymorphic marker locus (PIC = 70%) linked to one disease locus and unlinked to the second. The power to de...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370070306
更新日期:1990-01-01 00:00:00
abstract::The complex etiology of common diseases like cardiovascular disease, diabetes, hypertension, and rheumatoid arthritis has led investigators to focus on the genetics of correlated phenotypes and risk factors. Joint analysis of multiple disease-related phenotypes may reveal genes of pleiotropic effect and increase analy...
journal_title:Genetic epidemiology
pub_type:
doi:10.1002/gepi.20470
更新日期:2009-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s467
更新日期:2001-01-01 00:00:00
abstract::Atopic disease is generally recognized to be familial, although specific genetic components have yet to be identified. High levels of a unique class of immunoglobulins, immunoglobulin E (IgE), have been shown to be associated with allergies. Several investigators have reported evidence indicating a recessive regulator...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370020402
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20057
更新日期:2005-04-01 00:00:00
abstract::The 4 allele of apolipoprotein E (APOE) is associated with increased risk of two major causes of death in low-mortality populations: ischemic heart disease and Alzheimer's disease. It is less common among centenarians than at younger ages. Therefore, it is likely that it is associated with excess risk of death. This a...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.0164
更新日期:2002-02-01 00:00:00
abstract::Smoking has been observed to affect plasma sex hormones and body mass index. The relationship between smoking, body mass index, and plasma concentration of sex hormones was studied in normal adult male twins. The analyses were performed for between 150 and 159 twin pairs for whom hormonal data were available on both t...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370060303
更新日期:1989-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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journal_title:Genetic epidemiology
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370170738
更新日期:1999-01-01 00:00:00
abstract::An extension of the traditional regression of offspring on midparent (ROMP) method was used to estimate the heritability of the trait, test for marker association, and estimate the heritability attributable to a marker locus. The fifty replicates of the Genetic Analysis Workshop (GAW) 12 simulated general population d...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s794
更新日期:2001-01-01 00:00:00
abstract::Noncoding DNA contains gene regulatory elements that alter gene expression, and the function of these elements can be modified by genetic variation. Massively parallel reporter assays (MPRA) enable high-throughput identification and characterization of functional genetic variants, but the statistical methods to identi...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.22337
更新日期:2020-10-01 00:00:00
abstract::Several methods have been proposed to increase power in rare variant association testing by aggregating information from individual rare variants (MAF < 0.005). However, how to best combine rare variants across multiple ethnicities and the relative performance of designs using different ethnic sampling fractions remai...
journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Human apolipoprotein A-IV (APO A-IV) exhibits a common protein polymorphism detectable by isoelectric focusing (IEF) due to a single base substitution at codon 360 which replaces the frequently occurring glutamine residue (allele 1) with histidine (allele 2). Recently, sequence analysis of the APO A-IV coding region h...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370090503
更新日期:1992-01-01 00:00:00
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journal_title:Genetic epidemiology
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更新日期:2001-01-01 00:00:00
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journal_title:Genetic epidemiology
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更新日期:2004-05-01 00:00:00