Abstract:
:Increased adiposity has repeatedly been identified as a major risk factor for a variety of chronic diseases. However, the question still remains whether the amount of adipose tissue itself is genetically mediated. To address this question, a segregation analysis, using maximum likelihood techniques as implemented in the computer program Pedigree Analysis Package (PAP), was performed on fat mass (kilograms of body fat) in a large sample of extended Mexican American families residing in San Antonio, TX. The only model not rejected was a Mendelian mixed model for fat mass, incorporating genotype x sex interaction. In males the major gene accounted for 37% of the total variance compared with 43% in females. In both sexes homozygous recessive individuals have a fat mass more than double that of individuals of the other two genotypes. It was possible to reject linkage of the anonymous major gene for fat mass with several candidate loci for obesity. However, tentative evidence of linkage was detected with markers on both chromosomes 2 and 11, thereby providing hypotheses for future testing.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Comuzzie AG,Blangero J,Mahaney MC,Mitchell BD,Hixson JE,Samollow PB,Stern MP,MacCluer JWdoi
10.1002/gepi.1370120505subject
Has Abstractpub_date
1995-01-01 00:00:00pages
475-88issue
5eissn
0741-0395issn
1098-2272journal_volume
12pub_type
杂志文章abstract::Grade of membership analysis (GoM) may have particular relevance for genetic epidemiology. The method can flexibly relate genetic markers, clinical features, and environmental exposures to possible subtypes of disease termed pure types even when population allele frequencies and penetrance functions are not known. Hen...
journal_title:Genetic epidemiology
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journal_title:Genetic epidemiology
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abstract::Several methods have been proposed to increase power in rare variant association testing by aggregating information from individual rare variants (MAF < 0.005). However, how to best combine rare variants across multiple ethnicities and the relative performance of designs using different ethnic sampling fractions remai...
journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1115
更新日期:2002-06-01 00:00:00
abstract::The inheritance of pyloric stenosis is explained by a multifactorial threshold model with an underlying assumption that the liability for the disease is distributed in males and females showing a sex dimorphism. From the available data on familial occurrences of pyloric stenosis, it is shown, that an extra maternal ef...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370030102
更新日期:1986-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20036
更新日期:2005-01-01 00:00:00
abstract::We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the popula...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370120623
更新日期:1995-01-01 00:00:00
abstract::In the last two decades, complex traits have become the main focus of genetic studies. The hypothesis that both rare and common variants are associated with complex traits is increasingly being discussed. Family-based association studies using relatively large pedigrees are suitable for both rare and common variant id...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21844
更新日期:2014-11-01 00:00:00
abstract::Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped individual than small pedigrees. We propose accurate and computationally efficient methods to cal...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20160
更新日期:2006-09-01 00:00:00
abstract::The Framingham Heart Study data, as well as a related simulated data set, were generously provided to the participants of the Genetic Analysis Workshop 13 in order that newly developed and emerging statistical methodologies could be tested on that well-characterized data set. The impetus driving the development of nov...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.10285
更新日期:2003-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21645
更新日期:2012-09-01 00:00:00
abstract::Orientals consisting of Japanese, Chinese, Koreans, and Filipinos are clearly at higher risk for cleft lip with or without cleft palate [CL(P)] than whites, Puerto Ricans, and Hawaiians/part-Hawaiians in Hawaii. Using the model of diallele cross, CL(P) incidences in incrosses and outcrosses involving 564,002 live birt...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370040603
更新日期:1987-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21779
更新日期:2014-01-01 00:00:00
abstract::Large-scale meta-analyses of genome-wide association scans (GWAS) have been successful in discovering common risk variants with modest and small effects. The detection of lower frequency signals will undoubtedly require concerted efforts of at least similar scale. We investigate the sample size-dictated power limits o...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20627
更新日期:2011-12-01 00:00:00
abstract::Our goal was to detect genes contributing to the P300 component of the event related potential (ERP). We found that all of the ERP traits were highly correlated. Most of them distinguished alcoholics from nonalcoholics. To have one summary variable for the ERP traits, we calculated the first principal component (PRIN1...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370170728
更新日期:1999-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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更新日期:2004-11-01 00:00:00
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更新日期:1993-01-01 00:00:00
abstract::Noncoding DNA contains gene regulatory elements that alter gene expression, and the function of these elements can be modified by genetic variation. Massively parallel reporter assays (MPRA) enable high-throughput identification and characterization of functional genetic variants, but the statistical methods to identi...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.22337
更新日期:2020-10-01 00:00:00
abstract::The linkage between electronic health records (EHRs) and genotype data makes it plausible to study the genetic susceptibility of a wide range of disease phenotypes. Despite that EHR-derived phenotype data are subjected to misclassification, it has been shown useful for discovering susceptible genes, particularly in th...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.22080
更新日期:2017-12-01 00:00:00
abstract::Various statistical methods have been proposed to evaluate associations between measured genetic variants and disease, including some using family designs. For breast cancer and rare variants, we applied a modified segregation analysis method that uses the population cancer incidence and population-based case families...
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pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
abstract::It is generally accepted that cancer is caused by environmental and inherited factors but these are only partially identified. Family studies can be informative but they do not separate shared lifestyles and genes. We estimate familial risks for concordant cancers between spouses in common cancers of both sexes in ord...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/1098-2272(200102)20:2<247::AID-GEPI7>3.0.C
更新日期:2001-02-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370080104
更新日期:1991-01-01 00:00:00
abstract::Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were c...
journal_title:Genetic epidemiology
pub_type: 杂志文章,meta分析
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更新日期:1999-01-01 00:00:00
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