Genetic heterogeneity in Alzheimer's disease: a grade of membership analysis.

Abstract:

:Grade of membership analysis (GoM) may have particular relevance for genetic epidemiology. The method can flexibly relate genetic markers, clinical features, and environmental exposures to possible subtypes of disease termed pure types even when population allele frequencies and penetrance functions are not known. Hence, GoM may complement existing strategies that sometimes fail in the presence of heterogeneity or when case definition is not well established. To illustrate the method, individuals in the Seattle data set were evaluated with respect to affection status, age at onset, pedigree, sex, and genetic markers on chromosomes 19 and 21. Seven pure types were found which we have designated as: Early Onset, Late Onset, Probable, and Unaffected 1 to Unaffected 4.

journal_name

Genet Epidemiol

journal_title

Genetic epidemiology

authors

Corder EH,Woodbury MA

doi

10.1002/gepi.1370100628

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

495-9

issue

6

eissn

0741-0395

issn

1098-2272

journal_volume

10

pub_type

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