Comparison of two linkage inference procedures for genes related to the P300 component of the event related potential.


:Our goal was to detect genes contributing to the P300 component of the event related potential (ERP). We found that all of the ERP traits were highly correlated. Most of them distinguished alcoholics from nonalcoholics. To have one summary variable for the ERP traits, we calculated the first principal component (PRIN1). After adjusting for age and sex, we screened for linkage of PRIN1 to all of the markers using the two-point Haseman-Elston sib-pair test. We compared results obtained from computing a moving average of two-point p-values ("regional" inference) in an approximately 10 cM region with those obtained from single, two-point tests. Different "suggestive" and "significant" linkage regions were found using the two methods. Based on the regional method, areas on chromosomes 2 and 5 should be followed up in future studies.


Genet Epidemiol


Genetic epidemiology


Goldin LR,Chase GA




Has Abstract


1999-01-01 00:00:00








17 Suppl 1


  • Identifying SNPs predictive of phenotype using random forests.

    abstract::There has been a great interest and a few successes in the identification of complex disease susceptibility genes in recent years. Association studies, where a large number of single-nucleotide polymorphisms (SNPs) are typed in a sample of cases and controls to determine which genes are associated with a specific dise...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Bureau A,Dupuis J,Falls K,Lunetta KL,Hayward B,Keith TP,Van Eerdewegh P

    更新日期:2005-02-01 00:00:00

  • Inferential testing for linkage with GENEHUNTER-MODSCORE: the impact of the pedigree structure on the null distribution of multipoint MOD scores.

    abstract::The asymptotic distribution of [MOD] scores under the null hypothesis of no linkage is only known for affected sib pairs and other types of affected relative pairs. We have extended the GENEHUNTER-MODSCORE program to allow for simulations under the null hypothesis of no linkage to determine the empirical significance ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Mattheisen M,Dietter J,Knapp M,Baur MP,Strauch K

    更新日期:2008-01-01 00:00:00

  • TDT with covariates and genomic screens with mod scores: their behavior on simulated data.

    abstract::We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the popula...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Rice JP,Neuman RJ,Hoshaw SL,Daw EW,Gu C

    更新日期:1995-01-01 00:00:00

  • Estimation of allele frequencies with data on sibships.

    abstract::Allele frequencies are generally estimated with data on a set of unrelated individuals. In genetic studies of late-onset diseases, the founding individuals in pedigrees are often not available, and so one is confronted with the problem of estimating allele frequencies with data on related individuals. We focus on sibp...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Broman KW

    更新日期:2001-04-01 00:00:00

  • Pooling data and linkage analysis in the chromosome 5q candidate region for asthma.

    abstract::We investigated a variety of methods for pooling data from eight data sets (n = 5,424 subjects) to validate evidence for linkage of markers in the cytokine cluster on chromosome 5q31-33 to asthma and asthma-associated phenotypes. Chromosome 5 markers were integrated into current genetic linkage and physical maps, and ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章,meta分析


    authors: Jacobs KB,Burton PR,Iyengar SK,Elston RC,Palmer LJ

    更新日期:2001-01-01 00:00:00

  • On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.

    abstract::For the association analysis of whole-genome sequencing (WGS) studies, we propose an efficient and fast spatial-clustering algorithm. Compared to existing analysis approaches for WGS data, that define the tested regions either by sliding or consecutive windows of fixed sizes along variants, a meaningful grouping of ne...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Loehlein Fier H,Prokopenko D,Hecker J,Cho MH,Silverman EK,Weiss ST,Tanzi RE,Lange C

    更新日期:2017-05-01 00:00:00

  • Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.

    abstract::For most complex diseases, the fraction of heritability that can be explained by the variants discovered from genome-wide association studies is minor. Although the so-called "rare variants" (minor allele frequency [MAF] < 1%) have attracted increasing attention, they are unlikely to account for much of the "missing h...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Lin WY,Yi N,Lou XY,Zhi D,Zhang K,Gao G,Tiwari HK,Liu N

    更新日期:2013-09-01 00:00:00

  • Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs.

    abstract::We investigated the independent contributions of a candidate gene and an environmental factor, and the presence of gene x environment (G x E) interaction, in the etiology of a disease in the Genetic Analysis Workshop (GAW) 12 problem 2 simulated data using a two-stage approach utilizing both case-control and case-pare...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Norris JM,Selinger-Leneman H,Génin E

    更新日期:2001-01-01 00:00:00

  • Ordered multinomial regression for genetic association analysis of ordinal phenotypes at Biobank scale.

    abstract::Logistic regression is the primary analysis tool for binary traits in genome-wide association studies (GWAS). Multinomial regression extends logistic regression to multiple categories. However, many phenotypes more naturally take ordered, discrete values. Examples include (a) subtypes defined from multiple sources of ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: German CA,Sinsheimer JS,Klimentidis YC,Zhou H,Zhou JJ

    更新日期:2020-04-01 00:00:00

  • Meta-analysis by combining p-values: simulated linkage studies.

    abstract::Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were c...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章,meta分析


    authors: Guerra R,Etzel CJ,Goldstein DR,Sain SR

    更新日期:1999-01-01 00:00:00

  • Tag SNPs chosen from HapMap perform well in several population isolates.

    abstract::Population isolates may be particularly useful for association studies of complex traits. This utility, however, largely depends on the transferability of tag SNPs chosen from reference samples, such as HapMap, to samples from such populations. Factors that characterize population isolates, such as widespread genetic ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Service S,International Collaborative Group on Isolated Populations.,Sabatti C,Freimer N

    更新日期:2007-04-01 00:00:00

  • Phenotypic effects of apolipoprotein structural variation on lipid profiles: II. Apolipoprotein A-IV and quantitative lipid measures in the healthy women study.

    abstract::Apolipoprotein A-IV (APO A-IV) is a major protein component of mesenteric lymph chylomicrons and very-low-density lipoproteins. It is found in plasma predominantly unassociated with major lipoprotein fractions and in high density lipoproteins. APO A-IV exhibits structural heterogeneity owing to two codominant alleles,...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Eichner JE,Kuller LH,Ferrell RE,Kamboh MI

    更新日期:1989-01-01 00:00:00

  • Genetic and environmental causes of variation in renal tubular handling of sodium and potassium: a twin study.

    abstract::We have conducted a study of renal sodium and potassium reabsorption in 205 pairs of twins on freely chosen diets; 89 of the subjects were studied on more than one occasion. Renal tubular sodium and potassium handling, as measured by the fractional excretions FENa and FEK, show repeatable differences between individua...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Whitfield JB,Martin NG

    更新日期:1985-01-01 00:00:00

  • Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error.

    abstract::The purpose of this work is the development of linear trend tests that allow for error (LTT ae), specifically incorporating double-sampling information on phenotypes and/or genotypes. We use a likelihood framework. Misclassification errors are estimated via double sampling. Unbiased estimates of penetrances and genoty...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Gordon D,Haynes C,Yang Y,Kramer PL,Finch SJ

    更新日期:2007-12-01 00:00:00

  • Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring.

    abstract::Linkage disequilibrium mapping of quantitative traits is a powerful method for dissecting the genetic etiology of complex phenotypes. Quantitative traits, however, often exhibit characteristics that make their use problematic. For example, the distribution of the trait may be censored, highly skewed, or contaminated w...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Allen AS,Martin ER,Qin X,Li YJ

    更新日期:2006-04-01 00:00:00

  • Information on ancestry from genetic markers.

    abstract::It is possible to estimate the proportionate contributions of ancestral populations to admixed individuals or populations using genetic markers, but different loci and alleles vary considerably in the amount of information that they provide. Conventionally, the allele frequency difference between parental populations ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Pfaff CL,Barnholtz-Sloan J,Wagner JK,Long JC

    更新日期:2004-05-01 00:00:00

  • On the detection of linkage in multiple data sets: a comparison of various statistical approaches.

    abstract::We contrast the pooling of multiple data sets with the compound HLOD (HLOD-C) and the posterior probability of linkage (PPL), two approaches that have been shown to have more power in the presence of genetic heterogeneity. We also propose and evaluate several multipoint extensions. ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Van Eerdewegh P,Dowd M,Dupuis J,Falls K,Hayward B,Santangelo SL

    更新日期:2001-01-01 00:00:00

  • Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children.

    abstract::The transmission disequilibrium test (TDT), originally developed for mapping disease genes, has recently been extended to identify quantitative trait loci (QTL). For quantitative traits important for human health, generally multiple QTLs are involved. In the investigation of the statistical properties of the TDT, back...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Deng HW,Li J,Recker RR

    更新日期:2001-11-01 00:00:00

  • Random effects model for meta-analysis of multiple quantitative sibpair linkage studies.

    abstract::The growing interest in detection of genetic effects for complex traits along with molecular revolution has stimulated many linkage studies. Multiple replication studies tend to produce different results. In such situations, rigorous meta-analysis methods can be useful for assessing the overall evidence for linkage. W...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Li Z,Rao DC

    更新日期:1996-01-01 00:00:00

  • Effect of linkage disequilibrium between markers in linkage and association analyses.

    abstract::Contributions to Group 17 of the Genetic Analysis Workshop 15 considered dense markers in linkage disequilibrium (LD) in the context of either linkage or association analysis. Three contributions reported on methods for modeling LD or selecting a subset of markers in linkage equilibrium to perform linkage analysis. Wh...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Dupuis J,Albers K,Allen-Brady K,Cho K,Elston RC,Kappen HJ,Tang H,Thomas A,Thomson G,Tsung E,Yang Q,Zhang W,Zhao K,Zheng G,Ziegler JT

    更新日期:2007-01-01 00:00:00

  • Two common polymorphisms in the APO A-IV coding gene: their evolution and linkage disequilibrium.

    abstract::Human apolipoprotein A-IV (APO A-IV) exhibits a common protein polymorphism detectable by isoelectric focusing (IEF) due to a single base substitution at codon 360 which replaces the frequently occurring glutamine residue (allele 1) with histidine (allele 2). Recently, sequence analysis of the APO A-IV coding region h...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Kamboh MI,Hamman RF,Ferrell RE

    更新日期:1992-01-01 00:00:00

  • A multimarker regression-based test of linkage for affected sib-pairs at two linked loci.

    abstract::We address the analytical problem of evaluating the evidence for linkage at a test locus while taking into account the effect of a known linked disease locus. The method we propose is a multimarker regression approach that models the identity-by-descent states for affected sib-pairs at a series of linked markers in te...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Barber MJ,Todd JA,Cordell HJ

    更新日期:2006-04-01 00:00:00

  • Demonstration of a common major gene with pleiotropic effects on immunoglobulin E levels and allergy.

    abstract::Atopic disease is generally recognized to be familial, although specific genetic components have yet to be identified. High levels of a unique class of immunoglobulins, immunoglobulin E (IgE), have been shown to be associated with allergies. Several investigators have reported evidence indicating a recessive regulator...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Borecki IB,Rao DC,Lalouel JM,McGue M,Gerrard JW

    更新日期:1985-01-01 00:00:00

  • Robust inference for variance components models in families ascertained through probands: I. Conditioning on proband's phenotype.

    abstract::A robust approach for estimating standard errors of variance components by using quantitative phenotypes from families ascertained through a proband with an extreme phenotypic value is presented. Estimators that use the multivariate normal distribution as a "working likelihood" are obtained by computing conditional ln...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Beaty TH,Liang KY

    更新日期:1987-01-01 00:00:00

  • The recurrence risks for isolated cases with incompletely penetrant X-linked conditions.

    abstract::The recurrence risks for an X-linked disease with incomplete penetrance are evaluated for a sib given that an isolated proband (male or female) is affected. The derived formulae are applied to the X-linked form of Alport and fragile X syndromes. ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Rogatko A

    更新日期:1986-01-01 00:00:00

  • Model-based linkage analysis with imprinting for quantitative traits: ignoring imprinting effects can severely jeopardize detection of linkage.

    abstract::Genes with imprinting (parent-of-origin) effects express differently when inheriting from the mother or from the father. Some genes for development and behavior in mammals are known to be imprinted. We developed parametric linkage analysis that accounts for imprinting effects for continuous traits, implementing it in ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Sung YJ,Rao DC

    更新日期:2008-07-01 00:00:00

  • Gene-dropping vs. empirical variance estimation for allele-sharing linkage statistics.

    abstract::In this study, we compare the statistical properties of a number of methods for estimating P-values for allele-sharing statistics in non-parametric linkage analysis. Some of the methods are based on the normality assumption, using different variance estimation methods, and others use simulation (gene-dropping) to find...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Jung J,Weeks DE,Feingold E

    更新日期:2006-12-01 00:00:00

  • Rank-based robust tests for quantitative-trait genetic association studies.

    abstract::Standard linear regression is commonly used for genetic association studies of quantitative traits. This approach may not be appropriate if the trait, on its original or transformed scales, does not follow a normal distribution. A rank-based nonparametric approach that does not rely on any distributional assumptions c...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Li Q,Li Z,Zheng G,Gao G,Yu K

    更新日期:2013-05-01 00:00:00

  • Estimation of a significance threshold for epigenome-wide association studies.

    abstract::Epigenome-wide association studies (EWAS) are designed to characterise population-level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA-methylation status at cytosine-guanine dinucleotide (CpG) sites, using platforms such as the Illumina 450k array that profile a subse...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Saffari A,Silver MJ,Zavattari P,Moi L,Columbano A,Meaburn EL,Dudbridge F

    更新日期:2018-02-01 00:00:00

  • Immunoglobulin allotyping (Gm, Km) of GAW5 families.

    abstract::The following Gm and Km immunoglobulin allotypes were determined on the Genetic Analysis Workshop 5 insulin-dependent diabetes mellitus (GAW5 IDDM) families: G1m (1,2,3,17), G2m (23), G3m (5,10,11,13,14,21,28) and Km (1,3). Since the allotype G2m (23) has been rarely studied, due to paucity of typing reagents, it was ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Field LL,Dugoujon JM

    更新日期:1989-01-01 00:00:00