Abstract:
:The restricted partition method (RPM) is a partitioning algorithm for examining multi-locus genotypes as (potentially non-additive) predictors of a quantitative trait. The motivating application was to develop a robust method to examine quantitative phenotypes for epistasis (gene-gene interactions), but the method can be applied without modification to gene-environment interactions. Simulation results indicate that the method provides an efficient way to identify loci contributing epistatically to a quantitative trait, even if the loci have no single locus effects. Statistical significance can be estimated through permutation testing. An example using real data involving the metabolism of a chemotherapy drug is included for illustration. Although the examples in this article involve 2-locus interactions, the RPM is computationally feasible for the analysis of more than two loci or factors.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Culverhouse R,Klein T,Shannon Wdoi
10.1002/gepi.20006subject
Has Abstractpub_date
2004-09-01 00:00:00pages
141-52issue
2eissn
0741-0395issn
1098-2272journal_volume
27pub_type
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