Abstract:
:A major locus that determines levels of apolipoprotein B (apoB) was revealed by likelihood analysis on 331 members of 36 pedigrees. The major locus explained 43.2% of the observed variance, with the remainder attributed to random environmental factors. Estimated mean apoB levels (mg/dl) were 110.5 +/- 2.5, 141.9 +/- 4.4, and 208.1 +/- 11.5 for low homozygotes, heterozygotes, and high homozygotes, respectively. The corresponding genotypic frequencies were 0.718, 0.259, and 0.023. The apoB locus explained 13% and 14% of the variance in total and low-density-lipoprotein cholesterol levels, respectively. Persons with elevated apoB had normal to high levels of total serum cholesterol and triglyceride and low to normal levels of high-density lipoprotein and apolipoprotein A-I. Sixteen members of three of the pedigrees were heterozygous for familial hypercholesterolemia (FH). Their apoB levels were estimated as 35.72 +/- 7.16 mg/dl above the apoB genotypic means, assuming that the two loci act independently. Therefore, two major loci, the FH locus and the apoB locus, affect two levels, apoB and LDL cholesterol.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Hasstedt SJ,Wu L,Williams RRdoi
10.1002/gepi.1370040202subject
Has Abstractpub_date
1987-01-01 00:00:00pages
67-76issue
2eissn
0741-0395issn
1098-2272journal_volume
4pub_type
杂志文章abstract::A dense set of 5,000 SNPs on a 10-Mb region of human chromosome 20 has been typed on samples of African Americans, East Asians, and United Kingdom Caucasians. There are departures from Hardy-Weinberg equilibrium beyond the level at which markers are often discarded because of possible genotyping errors. The observatio...
journal_title:Genetic epidemiology
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.21730
更新日期:2013-07-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章,meta分析
doi:10.1002/gepi.1370170798
更新日期:1999-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/1098-2272(2000)19:1+<::AID-GEPI8>3.0.CO;2-
更新日期:2000-01-01 00:00:00
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更新日期:2009-02-01 00:00:00
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