Abstract:
:Genome-wide association studies of discrete traits generally use simple methods of analysis based on chi(2) tests for contingency tables or logistic regression, at least for an initial scan of the entire genome. Nevertheless, more power might be obtained by using various methods that analyze multiple markers in combination. Methods based on sliding windows, wavelets, Bayesian shrinkage, or penalized likelihood methods, among others, were explored by various participants of Genetic Analysis Workshop 16 Group 1 to combine information across multiple markers within a region, while others used Bayesian variable selection methods for genome-wide multivariate analyses of all markers simultaneously. Imputation can be used to fill in missing markers on individual subjects within a study or in a meta-analysis of studies using different panels. Although multiple imputation theoretically should give more robust tests of association, one participant contribution found little difference between results of single and multiple imputation. Careful control of population stratification is essential, and two contributions found that previously reported associations with two genes disappeared after more precise control. Other issues considered by this group included subgroup analysis, gene-gene interactions, and the use of biomarkers.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Thomas DCdoi
10.1002/gepi.20465subject
Has Abstractpub_date
2009-01-01 00:00:00pages
S8-12eissn
0741-0395issn
1098-2272journal_volume
33 Suppl 1pub_type
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journal_title:Genetic epidemiology
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.21738
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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