Genetic association with multiple traits in the presence of population stratification.

Abstract:

:Testing association between a genetic marker and multiple-dependent traits is a challenging task when both binary and quantitative traits are involved. The inverted regression model is a convenient method, in which the traits are treated as predictors although the genetic marker is an ordinal response. It is known that population stratification (PS) often affects population-based association studies. However, how it would affect the inverted regression for pleiotropic association, especially with the mixed types of traits (binary and quantitative), is not examined and the performance of existing methods to correct for PS using the inverted regression analysis is unknown. In this paper, we focus on the methods based on genomic control and principal component analysis, and investigate type I error of pleiotropic association using the inverted regression model in the presence of PS with allele frequencies and the distributions (or disease prevalences) of multiple traits varying across the subpopulations. We focus on common alleles but simulation results for a rare variant are also reported. An application to the HapMap data is used for illustration.

journal_name

Genet Epidemiol

journal_title

Genetic epidemiology

authors

Yan T,Li Q,Li Y,Li Z,Zheng G

doi

10.1002/gepi.21738

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

571-80

issue

6

eissn

0741-0395

issn

1098-2272

journal_volume

37

pub_type

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