Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice.

abstract：:Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Senger MR,Evangelista TCS,Dantas RF,Santana MVDS,Gonçalves LCS,de Souza Neto LR,Ferreira SB,Silva-Junior FP

更新日期：2020-10-02 00:00:00

abstract：:The seroprevalence of toxoplasmosis in 832 pregnant women in Miracema, Rio de Janeiro, was determined and 75.1% (625) and 2.0% (17) were anti-Toxoplasma gondii IgG and IgM positive, respectively. Out of the 17 IgM positive pregnant women, only one had low avidity IgG corresponding to the acute phase of the infection. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ribeiro AC,Mutis MS,Fernandes O

更新日期：2008-09-01 00:00:00

abstract：:An epidemic of sporotrichosis, a subcutaneous mycosis caused by the fungus Sporothrix schenckii, is ongoing in Rio de Janeiro, Brazil, in which cases of human infection are related to exposure to cats. In an attempt to demonstrate the zoonotic character of this epidemic using molecular methodology, we characterised by...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Reis RS,Almeida-Paes R,Muniz Mde M,Tavares PM,Monteiro PC,Schubach TM,Gutierrez-Galhardo MC,Zancopé-Oliveira RM

更新日期：2009-08-01 00:00:00

abstract：:Sand fly identification is complex because it depends on the expertise of the taxonomist. The females show subtle morphological differences and the occurrence of the species complexes are usual in this taxon. Therefore, a fragment of the cytochrome c oxidase subunit I (COI) gene is used for taxon barcoding to resolve ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Laurito M,Ontivero IM,Almirón WR

更新日期：2019-11-28 00:00:00

abstract：:Infection of C3H/He mice with the Peruvian strain of Trypanosoma cruzi (Biodeme type I, Z2b), a macrophagotropic strain, determined severe parasitism of macrophages, necrosis of the spleen, and high host mortality. In the present study, pentoxifylline (PTX), an inhibitor of TNF-alpha was investigated on its action upo...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade SG,Magalhães Ldos A,Pessina DH

更新日期：2008-02-01 00:00:00

abstract：:In Mexico, despite the relatively high seroprevalence of Trypanosoma cruzi infection in humans in some areas, reported morbidity of Chagas disease is not clear. We determined clinical stage in 71 individuals seropositive to T. cruzi in the state of Puebla, Mexico, an area endemic for Chagas disease with a reported ser...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Sánchez-Guillén Mdel C,López-Colombo A,Ordóñez-Toquero G,Gomez-Albino I,Ramos-Jimenez J,Torres-Rasgado E,Salgado-Rosas H,Romero-Díaz M,Pulido-Pérez P,Pérez-Fuentes R

更新日期：2006-11-01 00:00:00

abstract：:Four superoxide dismutase (SOD) activities (SOD I, II, III, and IV) have been characterized in the epimastigote form of Trypanosoma cruzi. The total extract was subjected to two successive ammonium sulphate additions between 35 and 85%, and the resulting fraction was purified using two continuous chromatography proces...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mateo H,Marín C,Pérez-Cordón G,Sánchez-Moreno M

更新日期：2008-05-01 00:00:00

abstract：:The first steps in leishmaniasis are critical in determining the evolution of the disease. Major advances have recently been done in understanding this crucial moment. Fundamental research in parasite-vector interaction, parasite biology, insect saliva, and vertebrate host response have shed new light and uncovered a ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Almeida MC,Vilhena V,Barral A,Barral-Netto M

更新日期：2003-10-01 00:00:00

abstract：:Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluation of mRNA expressio...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Villela AD,Rodrigues-Junior VS,Pinto AFM,Falcão VCA,Sánchez-Quitian ZA,Eichler P,Bizarro CV,Basso LA,Santos DS

更新日期：2017-11-01 00:00:00

abstract：:Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good models for the study of hepatic fibrosis. Early changes are similar...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade SB,Andrade ZA

更新日期：2004-06-01 00:00:00

abstract：:The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variation...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Deubel V

更新日期：1992-01-01 00:00:00

abstract：:The principal vector of malaria in eastern Venezuela, Anopheles aquasalis, is exophagic and exophilic. Control using indoor insecticide house sprays has failed to lower the number of malaria cases. Therefore, studies were initiated in two villages of the eastern coastal state of Sucre to better understand this vector'...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Berti J,Zimmerman R,Amarista J

更新日期：1993-07-01 00:00:00

abstract：:Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/A...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gama WM,Oliveira LB,Chaves YO,Ribeiro F,Almeida TVR,Baptista BJA,Santana MF,Ferreira LC,Lacerda MVG,Nogueira PA

更新日期：2020-09-14 00:00:00

abstract：:In previous studies it was shown that the recombinant molecule, r-Sm14, induces high levels of protection against Schistosoma mansoni infection in two outbred animal models and immune crossprotection against infection by Fasciola hepatica in Swiss outbred mice. r-Sm14 was derived from a living worm extract, called SE,...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Thaumaturgo N,Vilar MM,Diogo CM,Edelenyi R,Tendler M

更新日期：2001-01-01 00:00:00

abstract：:We collected and analyzed 500 samples of human milk, from five Brazilian cities (100 from each) to detect methicillin-resistant strains of Staphylococcus aureus (MRSA) producing enterotoxins. We found 57 strains of MRSA, and the mecA gene, responsible for resistance, was detected in all of them using a specific molecu...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Novak FR,Almeida JA,Warnken MB,Ferreira-Carvalho BT,Hagler AN

更新日期：2000-01-01 00:00:00

abstract：:The biochemical and serological characteristics, virulence properties, and genetic relatedness of Shiga toxin-producing Escherichia coli (STEC) strains isolated in S o Paulo, from April 1989 through March 1990, were determined. This is also the first report on clinic findings of human STEC infections in Brazil. The on...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Guth BE,Ramos SR,Cerqueira AM,Andrade JR,Gomes TA

更新日期：2002-12-01 00:00:00

abstract：:Rhodnius ecuadoriensis is the second most important vector of Chagas Disease (CD) in Ecuador. The objective of this study was to describe (and compare) the life cycle, the feeding and defecation patterns under laboratory conditions of two populations of this specie [from the provinces of Manabí (Coastal region) and Lo...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Villacís AG,Arcos-Terán L,Grijalva MJ

更新日期：2008-11-01 00:00:00

abstract：:The yield as well as phenotypic and functional parameters of canine peripheral blood monocyte-derived macrophages were analyzed. The cells that remained adherent to Teflon after 10 days of culture had high phagocytic activity when inoculated with Leishmania chagasi. Flow cytometric analysis demonstrated that more than...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bueno R,Mello MN,Menezes CA,Dutra WO,Santos RL

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) - characterized by the absence of detectable HBsAg in the presence of HBV DNA - represents a potential threat for blood safety. OBJECTIVES:This study was conducted with the aim to investigate the serological and molecular characterization of occult HBV infection (OBI) among bl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mabunda N,Zicai AF,Ismael N,Vubil A,Mello F,Blackard JT,Lago B,Duarte V,Moraes M,Lewis L,Jani I

更新日期：2020-09-23 00:00:00

abstract：:The mechanisms that facilitate the adaptation of Trypanosoma cruzi to two distinct hosts, insect and vertebrate, are poorly understood, in part due to the limited ability to perform gene disruption studies by homologous recombination. This report describes a developmentally-defective phenotype that resulted from integ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Zacks MA

更新日期：2007-02-01 00:00:00

abstract：:The author studied by the complement fixation test the influenza virus strains isolated in Rio de Janeiro during the 1973 epidemic. He prepared immunesera in hamsters by the inoculation of the allantoic fluid from infected chick embryos with each of the 7 isolated strains and the standard strains. The soluble antigens...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lacorte JG

更新日期：1976-01-01 00:00:00

abstract：:Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira-Filho EF,Dos Santos DR,Durães-Carvalho R,da Silva A,de Lima GB,Batista Filho AFB,Pena LJ,Gil LH

更新日期：2019-01-01 00:00:00

abstract：:In visceral leishmaniasis, phlebotomine vectors are targets for control measures. Understanding the ecosystem of the vectors is a prerequisite for creating these control measures. This study endeavours to delineate the suitable locations of Phlebotomus argentipes with relation to environmental characteristics between ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kesari S,Bhunia GS,Kumar V,Jeyaram A,Ranjan A,Das P

更新日期：2011-08-01 00:00:00

abstract：:Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen peroxide into water molecules. The gene encoding APX has been characterized in 11 strains of Trypanosoma cruzi that are sensitive or resistant to benznidazole (BZ). Bioinformatic analysis revealed the presence of two complete copies ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Nogueira FB,Rodrigues JF,Correa MM,Ruiz JC,Romanha AJ,Murta SM

更新日期：2012-06-01 00:00:00

abstract：:Calomys callosus, Rengger 1830 (Rodentia, Cricetidae), a wild rodent found in Central Brazil, was studied to investigate its susceptibility to Toxoplasma gondii experimental infection and its humoral immune response against this protozoa. The electrophoretic profile of the serum proteins of C. callosus showed that IgG...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Favoreto-Júnior S,Ferro EA,Clemente D,Silva DA,Mineo JR

更新日期：1998-01-01 00:00:00

abstract：:Dipteran polytene chromosomes provide an excellent model for understanding in species complexes, as well as for structural and functional cytogenetics. The status of species in the Culex pipiens complex is controversial and the use of polytene chromosomes for cytogenetic analysis in the subfamily Culicinae has been di...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Campos J,Andrade CF,Recco-Pimentel SM

更新日期：2003-04-01 00:00:00

abstract：:The Brazilian variant of human immunodeficiency virus type 1 (HIV-1) subtype B, (serotype B"-GWGR), has a tryptophan replacing the proline in position 328 the HIV-1 envelope. A longer median time period from infection to acquired immunodeficiency syndrome (AIDS) for serotype B (B"-GWGR) infected subjects compared to t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Casseb J,Montanheiro P,Komninakis S,Brito A,Duarte AJ

更新日期：2004-02-01 00:00:00

abstract：:Discovered in 1909, Chagas disease was progressively shown to be widespread throughout Latin America, affecting millions of rural people with a high impact on morbidity and mortality. With no vaccine or specific treatment available for large-scale public health interventions, the main control strategy relies on preven...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Dias JC,Silveira AC,Schofield CJ

更新日期：2002-07-01 00:00:00

abstract：:The chromatin of Trypanosoma congolense was analyzed by electron microscopy. The chromatin is organized as nucleosome filaments but does not form a 30 nm fiber. There are five groups of histones, including a histone H1-like protein, which as a molecular weight within the range of the core histones, and is extremely hy...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Schlimme W,Burri M,Betschart B,Hecker H

更新日期：1994-04-01 00:00:00

abstract：:Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides brasiliensis in parti...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Richini-Pereira VB,Bosco Sde M,Theodoro RC,Macoris SA,Bagagli E

更新日期：2009-07-01 00:00:00