Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico.


:In Mexico, despite the relatively high seroprevalence of Trypanosoma cruzi infection in humans in some areas, reported morbidity of Chagas disease is not clear. We determined clinical stage in 71 individuals seropositive to T. cruzi in the state of Puebla, Mexico, an area endemic for Chagas disease with a reported seroprevalence of 7.7%. Diagnosis of Chagas disease was made by two standardized serological tests (ELISA, IHA). Individuals were stratified according to clinical studies. All patients were submitted to EKG, barium swallow, and barium enema. Groups were identified as indeterminate form (IF) asymptomatic individuals without evidence of abnormalities (n = 34 cases); those with gastrointestinal alterations (12 patients) including symptoms of abnormal relaxation of the lower esophageal sphincter and absent peristalsis in the esophageal body, grade I megaesophagus, and/or megacolon; patients with clinical manifestations and documented changes of chronic Chagas heart disease who were subdivided as follows: mild (8 patients)--mild electrocardiographic changes of ventricular repolarization, sinus bradychardia); moderate (6 patients)--left bundle branch block, right bundle branch block associated with left anterior fascicular block); severe (8 patients)--signs of cardiomegaly, dilated cardiomyopathy); and the associated form (3 cases) that included presence of both cardiomyopathy and megaesophagus. These data highlight the importance of accurate evaluation of the prevalence and clinical course of Chagas disease in endemic and non-endemic areas of Mexico.


Mem Inst Oswaldo Cruz


Sánchez-Guillén Mdel C,López-Colombo A,Ordóñez-Toquero G,Gomez-Albino I,Ramos-Jimenez J,Torres-Rasgado E,Salgado-Rosas H,Romero-Díaz M,Pulido-Pérez P,Pérez-Fuentes R




Has Abstract


2006-11-01 00:00:00














  • The type specimens of Apoidea (Hymenoptera) deposited in the Entomological Collection of Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

    abstract::A list of 41 Apoidea (Hymenoptera) type specimens deposited in the Entomological Collection of the Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil is presented. The types previously belonged to the Zikán and Schrottky private collections. A total of 11 holotypes and 30 paratypes are listed with their respective dat...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ferraz MV

    更新日期:1997-05-01 00:00:00

  • Experimental murine schistosomiasis mansoni: establishment of the chronic phase of the disease.

    abstract::After the acute hyperergic phase of schistosomal infection, the chronic phase of the disease corresponds to the establishment of a relative equilibrium between the host and the parasite. This involves: (1) A shift from the predominance of the TH2 response observed in the acute phase, to the predominance of the TH1 res...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Borojevic R

    更新日期:1992-01-01 00:00:00

  • Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice.

    abstract::Mycobacterium fortuitum is a rapidly growing nontuberculous Mycobacterium that can cause a range of diseases in humans. Complications from M. fortuitum infection have been associated with numerous surgical procedures. A protective immune response against pathogenic mycobacterial infections is dependent on the granulom...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Silva TR,Petersen AL,Santos Tde A,Almeida TF,Freitas LA,Veras PS

    更新日期:2010-08-01 00:00:00

  • Certifying the interruption of Chagas disease transmission by native vectors: cui bono?

    abstract::Certifying the absence of Chagas disease transmission by native vectors lacks scientific grounds and weakens long-term control-surveillance systems to the detriment of people living under risk conditions. Instead, a regular "certification of good practice" (including vector control-surveillance, case detection/patient...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Abad-Franch F,Diotaiuti L,Gurgel-Gonçalves R,Gürtler RE

    更新日期:2013-04-01 00:00:00

  • Ergosterol biosynthesis and drug development for Chagas disease.

    abstract::This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These comp...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Urbina JA

    更新日期:2009-07-01 00:00:00

  • A comparative study of congenital toxoplasmosis between public and private hospitals from Uberlândia, MG, Brazil.

    abstract::The main purpose of the present study was to examine if there is difference in terms of incidence rates of congenital toxoplasmosis among populations assisted in public and private hospitals from Uberlândia, state of Minas Gerais, Brazil. A total of 805 serum samples from cord blood were collected, being 500 from publ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Segundo GR,Silva DA,Mineo JR,Ferreira MS

    更新日期:2004-02-01 00:00:00

  • Deep sequencing of small RNAs reveals the repertoire of miRNAs and piRNAs in Biomphalaria glabrata.

    abstract:BACKGROUND:Biomphalaria glabrata snails are widely distributed in schistosomiasis endemic areas like America and Caribe, displaying high susceptibility to infection by Schistosoma mansoni. After the availability of B. glabrata genome and transcriptome data, studies focusing on genetic markers and small non-coding RNAs ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Queiroz FR,Portilho LG,Jeremias WJ,Babá ÉH,do Amaral LR,Silva LM,Coelho PMZ,Caldeira RL,Gomes MS

    更新日期:2020-07-01 00:00:00

  • [Ecology of Lutzomyia longipalpis (Lutz & Neiva, 1912) and possibilities of the existence of visceral leishmaniasis in Costa Rica].

    abstract::A semiarid area of northwest Costa Rica where Lutzomyia longipalpis is common in corrals around houses is described. Monthly captures of the sandfly during two consecutive years for fixed periods of time indicated that the insect bites avidly cows, horses, pigs, dogs and humans. From a total of 14,215 specimens, 90.5%...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Zeledón R,Murillo J,Gutierrez H

    更新日期:1984-10-01 00:00:00

  • Leishmanial infection: analysis of its first steps. A review.

    abstract::The first steps in leishmaniasis are critical in determining the evolution of the disease. Major advances have recently been done in understanding this crucial moment. Fundamental research in parasite-vector interaction, parasite biology, insect saliva, and vertebrate host response have shed new light and uncovered a ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: de Almeida MC,Vilhena V,Barral A,Barral-Netto M

    更新日期:2003-10-01 00:00:00

  • Humoral immune response to the anti-malaria vaccine SPf66 in the Colombian Atrato River region.

    abstract::The immunogenicity of anti-malaria synthetic vaccine SPf66 was tested in a region of the Colombian middle Atrato river. The specific serum antibodies against SPf66 were quantified in vaccinees and placebo injected controls for a two-years period post-immunization. The frequency of individuals showing seroconversion of...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lopera TM,Restrepo M,Blair S,García HI

    更新日期:1998-07-01 00:00:00

  • Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.

    abstract:BACKGROUND:Occult hepatitis B virus (HBV) - characterized by the absence of detectable HBsAg in the presence of HBV DNA - represents a potential threat for blood safety. OBJECTIVES:This study was conducted with the aim to investigate the serological and molecular characterization of occult HBV infection (OBI) among bl...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Mabunda N,Zicai AF,Ismael N,Vubil A,Mello F,Blackard JT,Lago B,Duarte V,Moraes M,Lewis L,Jani I

    更新日期:2020-09-23 00:00:00

  • Acute Chagas disease in the state of Pará, Amazon Region: is it increasing?

    abstract::Acute Chagas disease (ACD) has a distinct epidemiological profile in the Amazon Region, with cases and outbreaks of Trypanosoma cruzi infection being possibly related to the ingestion of contaminated food. Data on ACD in the state of Pará retrieved from 2000 to 2016 from the Brazilian Notifiable Diseases Information S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Santos VRCD,Meis J,Savino W,Andrade JAA,Vieira JRDS,Coura JR,Junqueira ACV

    更新日期:2018-01-01 00:00:00

  • Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium.

    abstract::An overview is presented of the results obtained with biodegradable sustained release devices (SRDs) containing a mixture of polymers and either isometamidium (ISMM) or ethidium. Under controlled laboratory conditions (monthly challenge with tsetse flies infected with Trypanosoma congolense) the protection period in S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,评审


    authors: Geerts S,Brandt J,De Deken R

    更新日期:1999-03-01 00:00:00

  • Acute Chagas disease in El Salvador 2000-2012 - need for surveillance and control.

    abstract::Several parasitological studies carried out in El Salvador between 2000-2012 showed a higher frequency of acute cases of Chagas disease than that in other Central American countries. There is an urgent need for improved Chagas disease surveillance and vector control programs in the provinces where acute Chagas disease...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Sasagawa E,Aguilar AV,Ramírez MA,Chévez JE,Nakagawa J,Cedillos RA,Kita K

    更新日期:2014-04-01 00:00:00

  • Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon.

    abstract::Infusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary metabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Coutinho JP,Aguiar AC,dos Santos PA,Lima JC,Rocha MG,Zani CL,Alves TM,Santana AE,Pereira Mde M,Krettli AU

    更新日期:2013-12-01 00:00:00

  • Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina.

    abstract::St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) present ecological and antigenic similarities and are responsible for serious human diseases. In addition, WNV is a significant pathogen in terms of equine health. The purpose of our study was to analyse the seroprevalence of SLEV and WNV in equine sera col...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Tauro L,Marino B,Diaz LA,Lucca E,Gallozo D,Spinsanti L,Contigiani M

    更新日期:2012-06-01 00:00:00

  • Plants against snake-bites.

    abstract::Small molecular weight compounds from Mandevilla velutina and from Eclipta prostata were found to be active against snakebite. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Mors WB

    更新日期:1991-01-01 00:00:00

  • A palaeoparasitological analysis of rodent coprolites from the Cueva Huenul 1 archaeological site in Patagonia (Argentina).

    abstract::The aim of the present study was to examine the parasite fauna present in rodent coprolites collected from Cueva Huenul 1 (CH1), northern Neuquén (Patagonia, Argentina), an archaeological site that provides stratified sequences of archaeological and palaeontological remains dating from the Late Pleistocene/Early Holoc...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Beltrame MO,Sardella NH,Fugassa MH,Barberena R

    更新日期:2012-08-01 00:00:00

  • Zika virus damages the human placental barrier and presents marked fetal neurotropism.

    abstract::An unusually high incidence of microcephaly in newborns has recently been observed in Brazil. There is a temporal association between the increase in cases of microcephaly and the Zika virus (ZIKV) epidemic. Viral RNA has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. H...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Noronha Ld,Zanluca C,Azevedo ML,Luz KG,Santos CN

    更新日期:2016-05-01 00:00:00

  • Mast cell changes in experimental diabetes: focus on attenuation of allergic events.

    abstract::The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective trea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Carvalho VF,Barreto EO,Cordeiro RS,Lagente V,Martins MA,e Silva PM

    更新日期:2005-03-01 00:00:00

  • Biochemistry and mode of action of the Bacillus sphaericus toxins.

    abstract::Bacillus sphaericus produces at least two toxins which are highly toxic to mosquito larvae. The binary toxin, which is comprised of proteins of 51.4 and 41.9 kDa, is present in all highly insecticidal strains. The 100 kDa SSII-1 toxin is present in most highly insecticidal as well as the weakly insecticidal strains. T...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Davidson EW

    更新日期:1995-01-01 00:00:00

  • Culicidae (Diptera) selection of humans, chickens and rabbits in three different environments in the province of Chaco, Argentina.

    abstract::Studies were conducted to determine the selection of humans, chickens and rabbits by Culicidae in three different environments in the province of Chaco, Argentina. Mosquitoes were collected fortnightly using cylindrical metal traps containing animal bait (chickens and rabbits). The mosquitoes were collected between Ju...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Stein M,Zalazar L,Willener JA,Almeida FL,Almirón WR

    更新日期:2013-08-01 00:00:00

  • ERRATUM: Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly".

    abstract::[This corrects the article doi: 10.1590/0074-02760180073]. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,已发布勘误



    更新日期:2018-01-01 00:00:00

  • Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom.

    abstract::Cells die through a programmed process or accidental death, know as apoptosis or necrosis, respectively. Bothrops jararaca is a snake whose venom inhibits the growth of Trypanosoma cruzi epimastigote forms causing mitochondrion swelling and cell death. The aim of the present work was to determine the type of death ind...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Deolindo P,Teixeira-Ferreira AS,Melo EJ,Arnholdt AC,Souza Wd,Alves EW,DaMatta RA

    更新日期:2005-02-01 00:00:00

  • BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis--review.

    abstract::The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 历史文章,杂志文章,评审


    authors: Benévolo-de-Andrade TC,Monteiro-Maia R,Cosgrove C,Castello-Branco LR

    更新日期:2005-08-01 00:00:00

  • Detection and characterization of rotavirus G and P types from children participating in a rotavirus vaccine trial in Belém, Brazil.

    abstract::This study sought the characterization of rotaviruses in a trial with a tetravalent rhesus-human rotavirus vaccine in Belém, Brazil in children who received three doses of vaccine or placebo in the 1st, 3rd and 5th months of life. Rotavirus electropherotypes, subgroups, G serotypes, G, [P] and [P], G genotypes were de...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mascarenhas JD,Linhares AC,Gabbay YB,Leite JP

    更新日期:2002-01-01 00:00:00

  • Partial molecular characterization of Sm8, a tegumental antigen of Schistosoma mansoni.

    abstract::Sm8 is a major tegumental antigen of Schistosoma mansoni. The partial cDNA was isolated and analyzed. Sequence analysis revealed transmembrane compatible hydrophobic domains and a putative leucine zipper pattern. The mRNA and the protein are predominantly expressed in adult worms. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Abath FG,Xavier EM,Montenegro SM,Werkhauser RP

    更新日期:2002-01-01 00:00:00

  • Hepatitis C virus quantification in serum and saliva of HCV-infected patients.

    abstract::The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this stu...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Menezes GB,Pereira FA,Duarte CA,Carmo TM,Silva Filho HP,Zarife MA,Krieger MA,Reis EA,Reis MG

    更新日期:2012-08-01 00:00:00

  • Pharmacokinetic profile of tert-butylaminoethanethiol.

    abstract::A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification wit...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Andrade MH,Freire AC,Nelson DL

    更新日期:1990-07-01 00:00:00

  • In vitro and in vivo anti-Trypanosoma cruzi activity of a novel nitro-derivative.

    abstract::Nitroarylidenemalononitriles and their cyanoacetamide derivatives with remarkable anti-epimastigote properties, were synthesized attempting to obtain new 3,5-diamino-4-(5'-nitroarylidene)-4H-thiadiazine 1,1-dioxide derivatives, which in previous reports had shown anti-Trypanosoma cruzi activity. Tests to evaluate the ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Muelas-Serrano S,Le-Senne A,Fernandez-Portillo C,Nogal JJ,Ochoa C,Gomez-Barrio A

    更新日期:2002-06-01 00:00:00