Molecular approaches for eco-epidemiological studies of Paracoccidioides brasiliensis.

Abstract:

:Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides brasiliensis in particular, important eco-epidemiological aspects, such as environmental distribution and new hosts were clarified through molecular approaches. These methodologies also contributed to a better understanding about the genetic variability of this pathogen; thus, P. brasiliensis is now assumed to represent a species complex. The present review focuses on some recent findings about the current taxonomic status of P. brasiliensis, its phylogenetic and speciation processes, as well as on some practical applications for the molecular detection of this pathogen in environmental and clinical materials.

journal_name

Mem Inst Oswaldo Cruz

authors

Richini-Pereira VB,Bosco Sde M,Theodoro RC,Macoris SA,Bagagli E

doi

10.1590/s0074-02762009000400018

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

636-43

issue

4

eissn

0074-0276

issn

1678-8060

pii

S0074-02762009000400018

journal_volume

104

pub_type

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