Abstract:
:Cancer diagnosis is based on visual examination under a microscope of tissue sections from biopsies. But whereas pathologists rely on tissue stains to identify morphological features, automated tissue recognition using color is fraught with problems that stem from image intensity variations due to variations in tissue preparation, variations in spectral signatures of the stained tissue, spectral overlap and spatial aliasing in acquisition, and noise at image acquisition. We present a blind method for color decomposition of histological images. The method decouples intensity from color information and bases the decomposition only on the tissue absorption characteristics of each stain. By modeling the charge-coupled device sensor noise, we improve the method accuracy. We extend current linear decomposition methods to include stained tissues where one spectral signature cannot be separated from all combinations of the other tissues' spectral signatures. We demonstrate both qualitatively and quantitatively that our method results in more accurate decompositions than methods based on non-negative matrix factorization and independent component analysis. The result is one density map for each stained tissue type that classifies portions of pixels into the correct stained tissue allowing accurate identification of morphological features that may be linked to cancer.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Gavrilovic M,Azar JC,Lindblad J,Wahlby C,Bengtsson E,Busch C,Carlbom IBdoi
10.1109/TMI.2013.2239655subject
Has Abstractpub_date
2013-06-01 00:00:00pages
983-94issue
6eissn
0278-0062issn
1558-254Xjournal_volume
32pub_type
杂志文章abstract::In this paper, we present a novel technique based on nonrigid image registration for myocardial motion estimation using both untagged and 3-D tagged MR images. The novel aspect of our technique is its simultaneous usage of complementary information from both untagged and 3-D tagged MR images. To estimate the motion wi...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2188104
更新日期:2012-06-01 00:00:00
abstract::Given that heart disease can cause abnormal motion dynamics over the cardiac cycle, understanding and quantifying cardiac motion can provide insight for clinicians to aid with diagnosis, therapy planning, and determining prognosis. The goal of this paper is to extract population-specific motion patterns from 3D displa...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2405579
更新日期:2015-07-01 00:00:00
abstract::Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for second-trimester anomaly screening, for which ultrasound (US) is employed. Although expert sonographers are adept at reading US images, MR images which closely resemble anatomical images are much easier...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3018560
更新日期:2020-12-01 00:00:00
abstract::A two-stage algorithm for extraction of the ventricular chambers (endocardial surfaces) in flow-enhanced magnetic resonance images is described. In the first stage, the approximate locations and sizes of the endocardial surfaces are determined by intensity thresholding. In the second stage, points on each approximated...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.370402
更新日期:1995-01-01 00:00:00
abstract::X-ray computed tomography (CT) using sparse projection views is a recent approach to reduce the radiation dose. However, due to the insufficient projection views, an analytic reconstruction approach using the filtered back projection (FBP) produces severe streaking artifacts. Recently, deep learning approaches using l...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2823768
更新日期:2018-06-01 00:00:00
abstract::An electrical impedance tomography (EIT) system that uses the optimal current method to inject currents and the regularized Newton-Raphson algorithm to reconstruct an image of resistivity distribution is discussed. Iterative methods to derive the optimal current patterns through iterative physical measurements are dev...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.192684
更新日期:1992-01-01 00:00:00
abstract::A reconstruction algorithm to simultaneously estimate the shape and location of three-dimensional breast cancer tumor is presented and its utility is analyzed. The approach is based on a spherical harmonic decomposition to capture the shape of the tumor. We combine a gradient descent optimization method with a direct ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2006.881377
更新日期:2006-10-01 00:00:00
abstract::Ultrasound (US) imaging is the primary imaging modality for pediatric hydronephrosis, which manifests as the dilation of the renal collecting system (CS). In this paper, we present a new framework for the segmentation of renal structures, kidney and CS, from 3DUS scans. First, the kidney is segmented using an active s...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2572641
更新日期:2016-11-01 00:00:00
abstract::A noninvasive computer-aided-theragnosis (CAT) system was developed for the early therapeutic cancer response assessment in patients with locally advanced breast cancer (LABC) treated with neoadjuvant chemotherapy. The proposed CAT system was based on multi-parametric quantitative ultrasound (QUS) spectroscopic method...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2495246
更新日期:2016-03-01 00:00:00
abstract::Monte Carlo (MC) simulation provides a flexible and robust framework to efficiently evaluate and optimize image processing methods in emission tomography. In this work we present Brain-VISET (Voxel-based Iterative Simulation for Emission Tomography), a method that aims to simulate realistic [ (99m) Tc]-SPECT and [ (18...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2326041
更新日期:2014-10-01 00:00:00
abstract::We investigate using dual time-point PET data to perform Patlak modeling. This approach can be used for whole body dynamic PET studies in which we compute voxel-wise estimates of Patlak parameters using two frames of data for each bed position. Our approach directly uses list-mode arrival times for each event to estim...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2298868
更新日期:2014-04-01 00:00:00
abstract::Prostatic adenocarcinoma is the most commonly occurring cancer among men in the United States, second only to skin cancer. Currently, the only definitive method to ascertain the presence of prostatic cancer is by trans-rectal ultrasound (TRUS) directed biopsy. Owing to the poor image quality of ultrasound, the accurac...
journal_title:IEEE transactions on medical imaging
pub_type: 临床试验,杂志文章
doi:10.1109/TMI.2005.859208
更新日期:2005-12-01 00:00:00
abstract::Over the years, medical image tracking has gained considerable attention from both medical and research communities due to its widespread utility in a multitude of clinical applications, from functional assessment during diagnosis and therapy planning to structure tracking or image fusion during image-guided intervent...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2840820
更新日期:2018-11-01 00:00:00
abstract::Breast imaging via microwave tomography involves estimating the distribution of dielectric properties within the patient's breast on a discrete mesh. The number of unknowns in the discrete mesh can be very large for 3-D imaging, and this results in computational challenges. We propose a new approach where the discrete...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2008959
更新日期:2009-07-01 00:00:00
abstract::Direct reconstruction of kinetic parameters from raw projection data is a challenging task in molecular imaging using dynamic positron emission tomography (PET). This paper presents a new optimization transfer algorithm for penalized likelihood direct reconstruction of nonlinear parametric images that is easy to use a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2212203
更新日期:2012-10-01 00:00:00
abstract::A two-stage adaptive vector quantization scheme for radiographic image sequence coding is introduced. Each frame in the sequence is first decomposed into a set of vectors, corresponding to nonoverlapping spatially contiguous block of pixels. A codebook is generated using a training set of vectors drawn from the sequen...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.3938
更新日期:1988-01-01 00:00:00
abstract::The multi-channel nature of digital histopathological images presents an opportunity to exploit the correlated color channel information for better image modeling. Inspired by recent work in sparsity for single channel image classification, we propose a new simultaneous sparsity model for multi-channel histopathologic...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2306173
更新日期:2014-05-01 00:00:00
abstract::Quantitative accuracy of single photon emission computed tomography (SPECT) images is highly dependent on the photon scatter model used for image reconstruction. Monte Carlo simulation (MCS) is the most general method for detailed modeling of scatter, but to date, fully three-dimensional (3-D) MCS-based statistical SP...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2002.803130
更新日期:2002-08-01 00:00:00
abstract::In this paper, we present a wavelet-based multigrid approach to solve the perturbation equation encountered in optical tomography. With this scheme, the unknown image, the data, as well as the weight matrix are all represented by wavelet expansions, thus yielding a multiresolution representation of the original pertur...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.563666
更新日期:1997-04-01 00:00:00
abstract::Identification of anatomical features is a necessary step for medical image analysis. Automatic methods for feature identification using conventional pattern recognition techniques typically classify an object as a member of a predefined class of objects, but do not attempt to recover the exact or approximate shape of...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.293916
更新日期:1994-01-01 00:00:00
abstract::Multisource cone-beam computed tomography (CT) is an attractive approach of choice for superior temporal resolution, which is critically important for cardiac imaging and contrast enhanced studies. In this paper, we present a filtered-backprojection (FBP) algorithm for triple-source helical cone-beam CT. The algorithm...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2004817
更新日期:2009-03-01 00:00:00
abstract::We describe the efficient algebraic reconstruction (EAR) method, which applies to cone-beam tomographic reconstruction problems with a circular symmetry. Three independant steps/stages are presented, which use two symmetries and a factorization of the point spread functions (PSFs), each reducing computing times and ev...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.861707
更新日期:2006-02-01 00:00:00
abstract::A rule-based, low-level segmentation system that can automatically identify the space occupied by different structures of the brain by magnetic resonance imaging (MRI) is described. Given three-dimensional image data as a stack of slices, it can extract brain parenchyma, cerebro-spinal fluid, and high-intensity abnorm...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.57771
更新日期:1990-01-01 00:00:00
abstract::Active shape models bear a great promise for model-based medical image analysis. Their practical use, though, is undermined due to the need to train such models on large image databases. Automatic building of point distribution models (PDMs) has been successfully addressed and a number of autolandmarking techniques ar...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2004819
更新日期:2008-11-01 00:00:00
abstract::In in-utero MRI, motion correction for fetal body and placenta poses a particular challenge due to the presence of local non-rigid transformations of organs caused by bending and stretching. The existing slice-to-volume registration (SVR) reconstruction methods are widely employed for motion correction of fetal brain ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.2974844
更新日期:2020-09-01 00:00:00
abstract::We propose a joint information approach for automatic analysis of 2D echocardiography (echo) data. The approach combines a priori images, their segmentations and patient diagnostic information within a unified framework to determine various clinical parameters, such as cardiac chamber volumes, and cardiac disease labe...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2593900
更新日期:2017-01-01 00:00:00
abstract::This paper presents a virtual tagging framework for measuring, as well as visualising, myocardial deformation using magnetic resonance (MR) velocity imaging. Tagging grids are allocated artificially according to the deformation gradient with varying shapes and densities. The control points are then deformed such that ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2002.804429
更新日期:2002-09-01 00:00:00
abstract::True three-dimensional (3-D) volume reconstruction from fully 3-D data in positron emission tomography (PET) has only a limited clinical use because of its large computational burden. Fourier rebinning (FORE) of the fully 3-D data into a set of 2-D sinogram data decomposes the 3-D reconstruction process into multiple ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.870257
更新日期:2000-05-01 00:00:00
abstract::High-frame-rate ultrasonography based on coherent compounding of unfocused beams can potentially transform the assessment of cardiac function. As it requires successive waves to be combined coherently, this approach is sensitive to high-velocity tissue motion. We investigated coherent compounding of tilted diverging w...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2523346
更新日期:2016-07-01 00:00:00
abstract::Fast magnetic resonance imaging slice acquisition techniques such as single shot fast spin echo are routinely used in the presence of uncontrollable motion. These techniques are widely used for fetal magnetic resonance imaging (MRI) and MRI of moving subjects and organs. Although high-quality slices are frequently acq...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2051680
更新日期:2010-10-01 00:00:00