Functional assessment of coronary stenoses: can we live without it?

abstract：AIMS:Trans-fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate t...

journal_title：European heart journal

authors： Kleber ME,Delgado GE,Lorkowski S,März W,von Schacky C

更新日期：2016-04-01 00:00:00

abstract：AIMS:Delayed lipoprotein clearance is associated with atherosclerosis. This study examined whether chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnoea (OSA), can lead to hyperlipidaemia by inhibiting clearance of triglyceride rich lipoproteins (TRLP). METHODS AND RESULTS:Male C57BL/6J mice on hi...

journal_title：European heart journal

authors： Drager LF,Li J,Shin MK,Reinke C,Aggarwal NR,Jun JC,Bevans-Fonti S,Sztalryd C,O'Byrne SM,Kroupa O,Olivecrona G,Blaner WS,Polotsky VY

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The CONSENSUS trial was the first study to show prognostic improvement by an ACE inhibitor. Patients in NYHA class IV heart failure were treated with enalapril or placebo. After study completion (average 183 days) all patients were offered open-label enalapril therapy. This paper reports on the survival at t...

journal_title：European heart journal

authors： Swedberg K,Kjekshus J,Snapinn S

更新日期：1999-01-01 00:00:00

abstract：:Arbutamine (Gensia, Inc., San Diego, CA) is a newly-developed sympathomimetic agent specifically designed for cardiovascular stress testing. It has been successfully used for the detection of coronary artery disease in conjunction with electrocardiography, echocardiographic and radionuclide techniques. Arbutamine incr...

journal_title：European heart journal

authors： Armstrong WF,Bach DS

更新日期：1995-11-01 00:00:00

abstract：AIMS:Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between ...

journal_title：European heart journal

authors： Fadini GP,Avogaro A,Degli Esposti L,Russo P,Saragoni S,Buda S,Rosano G,Pecorelli S,Pani L,OsMed Health-DB Network.

更新日期：2015-09-21 00:00:00

abstract：AIMS:In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery of a fibrillin-1 (FBN1) mutation. M...

journal_title：European heart journal

authors： Détaint D,Faivre L,Collod-Beroud G,Child AH,Loeys BL,Binquet C,Gautier E,Arbustini E,Mayer K,Arslan-Kirchner M,Stheneur C,Halliday D,Beroud C,Bonithon-Kopp C,Claustres M,Plauchu H,Robinson PN,Kiotsekoglou A,De Backer

更新日期：2010-09-01 00:00:00

abstract：:The pharmacokinetics of glyceryl trinitrate are still not completely understood. The substance disappears rapidly from plasma largely by extrahepatic mechanisms. It is converted in glyceryl dinitrates and glyceryl mononitrates. After transdermal application of a controlled delivery system, plasma concentrations of gly...

journal_title：European heart journal

authors： Bogaert MG

更新日期：1988-01-01 00:00:00

abstract：AIMS:We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease. METHODS AND RESULTS:In 131 patients (age 65.7+/-0.7 years mean+/-SEM), ex vivo vascular reactivity to leptin (10(-13)-10(-7) M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxat...

journal_title：European heart journal

authors： Momin AU,Melikian N,Shah AM,Grieve DJ,Wheatcroft SB,John L,El Gamel A,Desai JB,Nelson T,Driver C,Sherwood RA,Kearney MT

更新日期：2006-10-01 00:00:00

abstract：:Myocardial catecholamine concentrations were determined in endomyocardial biopsies from patients with heart failure to assess if tissue catecholamine levels relate to the severity of myocardial damage or the aetiology of the underlying disease. Methodological studies revealed a good reproducibility of catecholamine de...

journal_title：European heart journal

authors： Regitz V,Leuchs B,Bossaller C,Sehested J,Rappolder M,Fleck E

更新日期：1991-08-01 00:00:00

abstract：:The treatment of hypertensive aircrew should also include changes in dietary habits, and advice against smoking. Relaxation exercises and changes in life style may prove of benefit. Increasing age, hypertension and smoking multiply to give a risk of cardiovascular event which merits careful assessment. ...

journal_title：European heart journal

authors： Bulpitt CJ

更新日期：1984-03-01 00:00:00

abstract：:A major consequence of chronic cardiac dysfunction is chronic overload of contractile myocardium. Various aetiologies, in reaction to this, may induce compensatory mechanisms consisting of excentric (dilatation) and concentric hypertrophy. Chronic left ventricular dysfunction is caused most frequently by myocardial in...

journal_title：European heart journal

authors： Ertl G,Gaudron P,Neubauer S,Bauer B,Horn M,Hu K,Tian R

更新日期：1993-07-01 00:00:00

abstract：:Experience accumulated from several large trials strongly suggests that beta-blockers should be used for the management of chronic heart failure[87]. It is appropriate to add beta-blockade to conventional therapy such as diuretics, ACE inhibitors and digoxin, as this was the approach used in the major trials. It is ap...

journal_title：European heart journal

authors： Cleland JG,Bristow MR,Erdmann E,Remme WJ,Swedberg K,Waagstein F

更新日期：1996-11-01 00:00:00

abstract：AIMS:To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Baseline neutrophil count was measured in 2865 patients in CLARITY-TIMI 28, a randomized trial of clopidogrel vs. placebo in STEMI patients under...

journal_title：European heart journal

authors： O'Donoghue M,Morrow DA,Cannon CP,Guo W,Murphy SA,Gibson CM,Sabatine MS

更新日期：2008-04-01 00:00:00

abstract：AIMS:Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXU...

journal_title：European heart journal

authors： Kappetein AP,Feldman TE,Mack MJ,Morice MC,Holmes DR,Ståhle E,Dawkins KD,Mohr FW,Serruys PW,Colombo A

更新日期：2011-09-01 00:00:00

abstract：AIMS:To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. METHODS AND RESULTS:Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detec...

journal_title：European heart journal

authors： Miyasaka Y,Barnes ME,Petersen RC,Cha SS,Bailey KR,Gersh BJ,Casaclang-Verzosa G,Abhayaratna WP,Seward JB,Iwasaka T,Tsang TS

更新日期：2007-08-01 00:00:00

abstract：AIMS:Patients with myocardial infarction (MI) presenting immediately after symptom onset may be treated less aggressively due to their non-elevated troponin status. We compared the initial treatment and clinical outcomes of patients presenting with evolving MI (EMI) with those presenting with MI. METHODS AND RESULTS:T...

journal_title：European heart journal

authors： Miller CD,Banerjee A,Mahaffey KW,Kontos MC,Fermann G,Pollack CV Jr,Antman E,Aylward P,Goodman SG,Santos R,Ferguson JJ,Califf RM,Hoekstra JW

更新日期：2007-05-01 00:00:00

abstract：AIMS:Short-QT syndrome 1 (SQT1) is an inherited channelopathy with accelerated repolarization due to gain-of-function in HERG/IKr. Patients develop atrial fibrillation, ventricular tachycardia (VT), and sudden cardiac death with pronounced inter-individual variability in phenotype. We generated and characterized transg...

journal_title：European heart journal

authors： Odening KE,Bodi I,Franke G,Rieke R,Ryan de Medeiros A,Perez-Feliz S,Fürniss H,Mettke L,Michaelides K,Lang CN,Steinfurt J,Pantulu ND,Ziupa D,Menza M,Zehender M,Bugger H,Peyronnet R,Behrends JC,Doleschall Z,Zur Hausen

更新日期：2019-03-07 00:00:00

abstract：AIMS:The aim of this study is to simultaneously evaluate the incremental prognostic value of multiple cardiac biomarkers reflecting different underlying pathophysiological processes in a well-characterized population of patients with non-ST-segment acute coronary syndrome (NSTE-ACS). METHODS AND RESULTS:We measured ca...

journal_title：European heart journal

authors： Scirica BM,Sabatine MS,Jarolim P,Murphy SA,de Lemos JL,Braunwald E,Morrow DA

更新日期：2011-03-01 00:00:00

abstract：AIMS:Coronary artery dissections are common findings following percutaneous transluminal coronary angioplasty and occur with an incidence of approximately 20% to 40%. The purpose of this study was to evaluate the impact of intravascular ultrasound for the prediction of severe dissections by pre-interventional analysis ...

journal_title：European heart journal

authors： Athanasiadis A,Haase KK,Wullen B,Treusch AW,Mahrholdt H,Voelker W,Baumbach A,Oberhoff M,Karsch KR

更新日期：1998-06-01 00:00:00

abstract：AIMS:Aldosterone plays a crucial role in cardiovascular disease. 'Systemic' inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important cardiovascular risk factor, is an inflammatory disease associated with increased plasma aldosterone...

journal_title：European heart journal

authors： Schäfer N,Lohmann C,Winnik S,van Tits LJ,Miranda MX,Vergopoulos A,Ruschitzka F,Nussberger J,Berger S,Lüscher TF,Verrey F,Matter CM

更新日期：2013-12-01 00:00:00

abstract：:The purpose of this study was to compare rubidium-82 PET with thallium-201 SPECT imaging in 150 patients. Both techniques followed a single dipyridamole-handgrip stress, and images were displayed using the same 3-dimensional format and quantitative colour scale. Coronary arteriography was employed to assign the correc...

journal_title：European heart journal

authors： Marwick TH,Go RT,MacIntyre WJ,Saha GB,Underwood DA

更新日期：1991-10-01 00:00:00

abstract：Aims:The ESC-EHRA Atrial Fibrillation Ablation Long-Term registry is a prospective, multinational study that aims at providing an accurate picture of contemporary real-world ablation for atrial fibrillation (AFib) and its outcome. Methods and results:A total of 104 centres in 27 European countries participated and wer...

journal_title：European heart journal

authors： Arbelo E,Brugada J,Blomström-Lundqvist C,Laroche C,Kautzner J,Pokushalov E,Raatikainen P,Efremidis M,Hindricks G,Barrera A,Maggioni A,Tavazzi L,Dagres N,on the behalf of the ESC-EHRA Atrial Fibrillation Ablation Long-term Regis

更新日期：2017-05-01 00:00:00

abstract：AIMS:Periconceptional folate supplementation prevents neural tube defects and possibly congenital heart defects (CHD) as well. The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. We studied the association between MTHFR 677C > ...

journal_title：European heart journal

authors： van Beynum IM,Kapusta L,den Heijer M,Vermeulen SH,Kouwenberg M,Daniëls O,Blom HJ

更新日期：2006-04-01 00:00:00

abstract：AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

journal_title：European heart journal

authors： Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

更新日期：2014-04-01 00:00:00

abstract：:Cardiac output was measured in 11 patients undergoing routine cardiac catheterization using a carbon dioxide rebreathing technique and compared with cardiac output measured by direct Fick and thermodilution. The carbon dioxide rebreathing technique gave consistently lower values for cardiac output than the other two m...

journal_title：European heart journal

authors： Nugent AM,McParland J,McEneaney DJ,Steele I,Campbell NP,Stanford CF,Nicholls DP

更新日期：1994-03-01 00:00:00

abstract：:In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

journal_title：European heart journal

authors： Jespersen CM

更新日期：1993-04-01 00:00:00

abstract：AIM:A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS:The association of rs20417 with CVD was...

journal_title：European heart journal

authors： Ross S,Eikelboom J,Anand SS,Eriksson N,Gerstein HC,Mehta S,Connolly SJ,Rose L,Ridker PM,Wallentin L,Chasman DI,Yusuf S,Paré G

更新日期：2014-09-01 00:00:00

abstract：AIMS:To assess the effect of experimentally induced atrial fibrillation on coronary flow in humans. METHODS AND RESULTS:In 16 patients (10 men, mean age 43+/-13 years) with normal coronary vessels, baseline and hyperaemic blood pressure and Doppler phasic coronary flow velocity were measured, using a 0.014 inch intrac...

journal_title：European heart journal

authors： Kochiadakis GE,Skalidis EI,Kalebubas MD,Igoumenidis NE,Chrysostomakis SI,Kanoupakis EM,Simantirakis EN,Vardas PE

更新日期：2002-05-01 00:00:00

abstract：AIMS:Various definitions of major bleeding have been used to evaluate safety in randomized controlled trials of antiplatelet therapy. We compared the definitions and rates of major bleeding in phase III randomized controlled trials of oral P2Y(12) inhibitors in the management of patients with acute coronary syndromes (...

journal_title：European heart journal

authors： Quinlan DJ,Eikelboom JW,Goodman SG,Welsh RC,Fitchett DH,Théroux P,Mehta SR

更新日期：2011-09-01 00:00:00

abstract：:Increased QT dispersion, which has been proposed as a marker of ventricular repolarization inhomogeneity, may predispose to ventricular arrhythmias. Data on QT dispersion in patients with congestive heart failure are scarce. In this study, conventional 12-lead ECGs were recorded in 135 consecutive patients with conges...

journal_title：European heart journal

authors： Fei L,Goldman JH,Prasad K,Keeling PJ,Reardon K,Camm AJ,McKenna WJ

更新日期：1996-02-01 00:00:00