Abstract:
INTRODUCTION:We hypothesized that microvascular disturbances in muscle tissue play a role in the reduced exercise capacity in juvenile dermatomyositis (JDM). METHODS:Children with JDM, children with juvenile idiopathic arthritis (clinical controls), and healthy children performed a maximal incremental cycloergometric test from which normalized concentration changes in oxygenated hemoglobin (Δ[O2 Hb]) and total hemoglobin (Δ[tHb]) as well as the half-recovery times of both signals were determined from the vastus medialis and vastus lateralis muscles using near-infrared spectroscopy. RESULTS:Children with JDM had lower Δ[tHb] values in the vastus medialis at work rates of 25%, 50%, 75%, and 100% of maximal compared with healthy children; the increase in Δ[tHb] with increasing intensity seen in healthy children was absent in children with JDM. Other outcome measures did not differ by group. CONCLUSIONS:The results suggest that children with JDM may experience difficulties in increasing muscle blood volume with more strenuous exercise.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Habers GE,De Knikker R,Van Brussel M,Hulzebos E,Stegeman DF,Van Royen A,Takken Tdoi
10.1002/mus.23484subject
Has Abstractpub_date
2013-01-01 00:00:00pages
108-15issue
1eissn
0148-639Xissn
1097-4598journal_volume
47pub_type
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