Near-infrared spectroscopy during exercise and recovery in children with juvenile dermatomyositis.

Abstract:

INTRODUCTION:We hypothesized that microvascular disturbances in muscle tissue play a role in the reduced exercise capacity in juvenile dermatomyositis (JDM). METHODS:Children with JDM, children with juvenile idiopathic arthritis (clinical controls), and healthy children performed a maximal incremental cycloergometric test from which normalized concentration changes in oxygenated hemoglobin (Δ[O2 Hb]) and total hemoglobin (Δ[tHb]) as well as the half-recovery times of both signals were determined from the vastus medialis and vastus lateralis muscles using near-infrared spectroscopy. RESULTS:Children with JDM had lower Δ[tHb] values in the vastus medialis at work rates of 25%, 50%, 75%, and 100% of maximal compared with healthy children; the increase in Δ[tHb] with increasing intensity seen in healthy children was absent in children with JDM. Other outcome measures did not differ by group. CONCLUSIONS:The results suggest that children with JDM may experience difficulties in increasing muscle blood volume with more strenuous exercise.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Habers GE,De Knikker R,Van Brussel M,Hulzebos E,Stegeman DF,Van Royen A,Takken T

doi

10.1002/mus.23484

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

108-15

issue

1

eissn

0148-639X

issn

1097-4598

journal_volume

47

pub_type

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