Abstract:
:Malignant mesothelioma (MM) is an aggressive neoplasm usually arising from the mesothelial surfaces of the pleural or peritoneal cavity. Currently, no standard therapy is available. The most commonly used therapy is cytoreductive surgery combined with systematic chemotherapy, but the median overall survival (OS) is less than 12 months; moreover, treatments are lacking for patients in whom chemotherapy has failed and/or who cannot withstand surgery. We investigated multiple minimally invasive therapies (cryosurgery, photodynamic therapy and intracavity chemotherapy) for the treatment of MM patients in whom systemic chemotherapy had failed. Twenty-seven patients were divided into comprehensive (combination of the three therapies) and palliative (intracavity chemotherapy only) treatment groups. The OS of patients who received comprehensive treatment was significantly longer than that of those who received palliative treatment (median OS: 64 vs. 9 months, P<0.001). This interesting result was not associated with treatment timing, but was closely associated with repeated treatments.
journal_name
Cryobiologyjournal_title
Cryobiologyauthors
Chen J,Liang B,Yuan Y,Liu C,Li L,Li H,Mu F,Zuo J,Xu Kdoi
10.1016/j.cryobiol.2012.08.003subject
Has Abstractpub_date
2012-12-01 00:00:00pages
284-8issue
3eissn
0011-2240issn
1090-2392pii
S0011-2240(12)00222-2journal_volume
65pub_type
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