Abstract:
:Some thermodynamic and structural aspects of propranolol-DPPC liposomes interaction were investigated by DSC and X-ray diffraction: the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until 1:1 drug/lipid molar ratio). However, the bilayer thickness increases significantly and the chains become perpendicular to the lamellar planes, for increasing drug content. At still higher propranolol concentrations a hexagonal phase occurs followed by a lamellar phase, in which the liposomes are destroyed. Moreover, the presence of propranolol has been found to impart fluidity to the lipid matrix.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Albertini G,Donati C,Phadke RS,Ponzi Bossi MG,Rustichelli Fdoi
10.1016/0009-3084(90)90171-msubject
Has Abstractpub_date
1990-09-01 00:00:00pages
331-7issue
3eissn
0009-3084issn
1873-2941pii
0009-3084(90)90171-Mjournal_volume
55pub_type
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