Synthesis of 2-n-(hexadecanoyl)-amino-4-nitrophenyl phosphorylcholine-hydroxide, a chromogenic substrate for assaying sphingomyelinase activity.

abstract：:The orientational order and rotational dynamics of 1-palmitoyl-2-[[2-[4-(6-phenyl-trans-1,3,5- hexatrienyl)phenyl]ethyl] carbon yl]-3-sn-phosphatidylcholine (DPH-PC) in dilinoleoylphosphatidylethanolamine (DLPE) and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) binary lipid mixtures were investigated. A previous stud...

journal_title：Chemistry and physics of lipids

authors： Cheng KH

更新日期：1989-10-01 00:00:00

abstract：:Sphingomyelin (N-acylsphingosin-1-phosphorylcholine) is a phospholipid preferentially found in the plasma membrane of mammalian cells. Signaling through the sphingomyelin pathway is associated with generation of ceramide, which acts as a second messenger in activating a variety of cellular functions. Ceramide belongs ...

journal_title：Chemistry and physics of lipids

authors： Krönke M

更新日期：1999-11-01 00:00:00

abstract：:Phosphatidylserine (PS) is an aminophospholipid that is prone to glycation. In oxidative conditions, glycated PS may lead to the formation of Amadori compounds and advanced glycated end products (AGEs), which are known to accumulate in diabetic patients. Nevertheless, there have been no studies that identified product...

journal_title：Chemistry and physics of lipids

authors： Maciel E,da Silva RN,Simões C,Melo T,Ferreira R,Domingues P,Domingues MR

更新日期：2013-09-01 00:00:00

abstract：:Irreversible electroporation (IRE) is a new technique in which a series of short pulses with high frequency electrical energy is applied on the targeted regions of cells or vesicles for their destruction or rupture formation. IRE induces lateral tension in the membranes of vesicles. We have investigated the electrosta...

journal_title：Chemistry and physics of lipids

authors： Karal MAS,Orchi US,Towhiduzzaman M,Ahamed MK,Ahmed M,Ahammed S,Mokta NA,Sharmin S,Sarkar MK

更新日期：2020-09-01 00:00:00

abstract：:The X-ray crystal structure of 3 beta-benzoyloxy-6 alpha-chloro-5 alpha-cholest-7-ene (IV) was determined by the heavy atom method and refined to R = 0.063 (space group P21, a = 11.364, b = 11.089, c = 12.232, beta = 99.43 degrees, Z = 2). IV was previously shown to be an important intermediate in the acid-catalyzed i...

journal_title：Chemistry and physics of lipids

authors： Wilson DK,Wilson WK,Quiocho FA,Schroepfer GJ Jr

更新日期：1988-08-01 00:00:00

abstract：:The activities of cytochrome P450-derived epoxide metabolites of omega-6 polyunsaturated fatty acids (PUFAs) in cellular homeostasis have generated considerable topical interest, but there is less information on the effects of omega-3 PUFA epoxides. Mass spectroscopic data on the epoxides of the omega-3 PUFA eicosapen...

journal_title：Chemistry and physics of lipids

authors： Cui PH,Zhang WV,Hook J,Tattam BN,Duke CC,Murray M

更新日期：2009-05-01 00:00:00

abstract：:DNA interactions with the bilayers of cationic liposomes were studied using a novel model experiment: DNAs were locally injected by a micropipette to a part of a giant unilamellar vesicle. The resulting phenomena were directly observed in optical microscope. Giant unilamellar vesicles (GUVs), about 100 microm in diame...

journal_title：Chemistry and physics of lipids

authors： Angelova MI,Tsoneva I

更新日期：1999-08-01 00:00:00

abstract：:The application of fluorescence methodologies to obtain information about the extent, dynamics and topology of peptide interaction with binary phospholipid (mainly zwitterionic/anionic) mixtures is reviewed. First, general approaches based on peptide (tryptophan residues) fluorescence properties that give information ...

journal_title：Chemistry and physics of lipids

authors： Loura LM,de Almeida RF,Coutinho A,Prieto M

更新日期：2003-01-01 00:00:00

abstract：:Various optically active hydroxy derivatives of polyunsaturated fatty acids were easily oxidised to their corresponding keto derivatives using Dess-Martin periodinane. The reaction was run on the millimolar scale with good yields and without appreciable isomerisation of the surrounding double bonds. Reduction of these...

journal_title：Chemistry and physics of lipids

authors： Iacazio G

更新日期：2003-10-01 00:00:00

abstract：:The gel-like liquid phase transition of dimyristoylphosphatidylcholine (DMPC) large unilamellar vesicles prepared by reverse phase evaporation has been investigated in buffers containing ethanol by quasi-elastic light scattering (QLS) and vibrational (infrared and Raman) spectroscopy. With the QLS technique, the relat...

journal_title：Chemistry and physics of lipids

authors： Hantz E,Cao A,Taillandier E

更新日期：1988-12-01 00:00:00

abstract：:The interactions of iodine, iodide and triiodide with phosphatidylcholine multilayers have been investigated in order to find supporting data for conduction mechanisms of iodine-doped bimolecular lipid membranes. On the basis of order-disorder parameters it can be concluded that phospholipid multilayers interact with ...

journal_title：Chemistry and physics of lipids

authors： Loshchilova E,Karvaly B

更新日期：1977-06-01 00:00:00

abstract：:Parkinson's disease is caused due to free radical generation in dopamine neurons leading to oxidative stress induced damage. The aim of this work was to ameliorate the free radical induced oxidative stress in rats by using TPGS (Tocopheryl polyethylene glycol 1000 succinate) loaded rutin nanoemulsion after oral admini...

journal_title：Chemistry and physics of lipids

authors： Sharma S,Rabbani SA,Narang JK,Hyder Pottoo F,Ali J,Kumar S,Baboota S

更新日期：2020-05-01 00:00:00

abstract：:The role of membrane cholesterol as a crucial regulator in the structure and function of membrane proteins and receptors is well documented. However, there is a lack of consensus on the mechanism for such regulation. We have previously shown that the function of an important neuronal receptor, the serotonin1A receptor...

journal_title：Chemistry and physics of lipids

authors： Pal S,Chakraborty H,Bandari S,Yahioglu G,Suhling K,Chattopadhyay A

更新日期：2016-03-01 00:00:00

abstract：:Low density lipoprotein (LDL) cholesterol is known to be oxidized both in vitro and in vivo giving rise to oxygenated sterols. Conflicting results, however, have been reported concerning both the nature and the relative concentrations of these compounds in oxidized human LDL. We examined the extracts obtained from Cu(...

journal_title：Chemistry and physics of lipids

authors： Malavasi B,Rasetti MF,Roma P,Fogliatto R,Allevi P,Catapano AL,Galli G

更新日期：1992-10-01 00:00:00

abstract：:Copper-induced peroxidation of liposomal palmitoyllinoleoyl-phosphatidylcholine (PLPC) is inhibited by alpha-tocopherol at micromolar concentrations. In our previous study we found that when the liposomes contain phosphatidylserine (PS), nanomolar concentrations of Toc were sufficient to inhibit peroxidation. In an at...

journal_title：Chemistry and physics of lipids

authors： Gal S,Lichtenberg D,Bor A,Pinchuk I

更新日期：2007-12-01 00:00:00

abstract：:Despite immense progress in our comprehension of lipase structure and function during the past decade, the basis for lipase acyl specificities has remained poorly understood. This review summarizes some recent advances in the understanding at the molecular-level of substrate acyl recognition by two members in a group ...

journal_title：Chemistry and physics of lipids

authors： Holmquist M

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Fat-soluble vitamins (A, D, E and K) are isoprene derived apolar molecules. While deficiencies of these vitamins have been associated with various diseases such as type 2 diabetes and cancer, high doses of Vitamin A and D can cause toxic effects. Accurate detection of serum levels of these vitamins have criti...

journal_title：Chemistry and physics of lipids

authors： Ertugrul S,Yucel C,Sertoglu E,Ozkan Y,Ozgurtas T

更新日期：2020-08-01 00:00:00

abstract：:The development of "molecular rulers" would allow one to quantitatively locate the penetration depth of intercalants within lipid bilayers. To this end, an attempt was made to correlate the (13)C NMR chemical shift of polarizable "reporter" carbons (e.g., carbonyls) of intercalants within DMPC liposomal bilayers - wit...

journal_title：Chemistry and physics of lipids

authors： Afri M,Alexenberg C,Aped P,Bodner E,Cohen S,Ejgenburg M,Eliyahu S,Gilinsky-Sharon P,Harel Y,Naqqash ME,Porat H,Ranz A,Frimer AA

更新日期：2014-12-01 00:00:00

abstract：:The permeability of liposomes to water, glucose, Ca2+ and alkaline cations was monitored by recording the change in absorbance at 450 nm using a rapid reaction stopped-flow spectrophotometer. Liposomes were prepared with egg phosphatidylcholine and concentrations of dolichol ranging from 0.1% to 9% (w/w). Net permeabi...

journal_title：Chemistry and physics of lipids

authors： Boscoboinik DO,Feliz M,Disalvo EA,Belocopitow E

更新日期：1985-11-01 00:00:00

abstract：:Poly(ethylene glycol)-coated liposomes were prepared with two new synthesised pegylated cholesterol (Chol) derivatives linked via carbamate bond. Poly(ethylene glycol) (PEG) was directly linked to Chol (PEG-Chol) or through a space arm of diaminebutane (PEG-L-Chol). In buffer, the physicochemical properties of PC/Chol...

journal_title：Chemistry and physics of lipids

authors： Carrion C,Domingo JC,de Madariaga MA

更新日期：2001-11-01 00:00:00

abstract：:The stratum corneum (SC), the outermost layer of the mammalian skin, is the main skin barrier. Ceramides (CERs) as the major constituent of the SC lipid matrix are of particular interest. At the moment, 11 classes of CERs are identified, but the effect of each single ceramide species is still not known. Therefore in t...

journal_title：Chemistry and physics of lipids

authors： Kessner D,Brezesinski G,Funari SS,Dobner B,Neubert RH

更新日期：2010-01-01 00:00:00

abstract：:[4,4-2H2]-, [5,5-2H2)-, [6-2H]-, [7-2H]-, [8,8-2H2)-, [11,11-2H2]-, [14,14-2H2]- and [18,18,18-2H3]-cis,cis-octadeca-6,9-dienoic (isolinoleic) acid were synthesized by supplementing cultures of the protozoan Tetrahymena with the corresponding deuterated cis-octadeca-9-enoic (oleic) acids. The cultures were harvested, ...

journal_title：Chemistry and physics of lipids

authors： Baenziger JE,Smith IC,Hill RJ

更新日期：1990-04-01 00:00:00

abstract：:Several cardiovascular risk factors are characterized by the coexistence of low-grade inflammation, enhanced oxidative stress and lipid peroxidation. It has been hypothesized that F2-isoprostanes, a product of in vivo lipid peroxidation, may transduce the effects of metabolic and hemodynamic abnormalities into increas...

journal_title：Chemistry and physics of lipids

authors： Davì G,Falco A,Patrono C

更新日期：2004-03-01 00:00:00

abstract：:The diffusion of a lipid fluorescent analogue across tight junctions in MDCK-I cells was studied by FRAP measurements. Cells were labelled with C6-NBD-PC at the apical cell membrane. Transepithelial resistance of MDCK-I cells was found to be higher than 3000 omega x cm2, which indicates the presence of a very tight ep...

journal_title：Chemistry and physics of lipids

authors： Grebenkämper K,Galla HJ

更新日期：1994-05-23 00:00:00

abstract：:This minireview describes the use of fluorescence polarization to characterize the dynamics and organization of biological membranes, lipoproteins, liposomes and other lipid-based assemblies. The advantages, disadvantages and limitations of this method are discussed. There is special emphasis on the multiprobe approac...

journal_title：Chemistry and physics of lipids

authors： Borenstain V,Barenholz Y

更新日期：1993-09-01 00:00:00

abstract：:Cholesteryl-phosphoryl-choline (CPC), a hybrid between cholesterol and lecithin, is incorporated into sonicated liposomes and erythrocyte membranes similarly to cholesterol. The effect of CPC on lipid microviscosity and degree of order is smaller, but not significantly than that of cholesterol. It is proposed that CPC...

journal_title：Chemistry and physics of lipids

authors： Lyte M,Shinitzky M

更新日期：1979-04-01 00:00:00

abstract：:Historically, cellular trafficking of lipids has received much less attention than protein trafficking, mostly because its biological importance was underestimated, involved sorting and translocation mechanisms were not known, and analytical tools were limiting. This has changed during the last decade, and we discuss ...

journal_title：Chemistry and physics of lipids

authors： Schlattner U,Tokarska-Schlattner M,Rousseau D,Boissan M,Mannella C,Epand R,Lacombe ML

更新日期：2014-04-01 00:00:00

abstract：:We found that extracellular addition of 2% bovine serum albumin (BSA) to a suspension of rabbit platelets after stimulation with platelet-activating factor resulted in a biphasic extraction of [3H]1-O-alkyl-2-O-methyl (or 2-O-methylcarbamyl)-sn-glycero-3-phosphocholine. A fast phase of extraction of the phospholipid p...

journal_title：Chemistry and physics of lipids

authors： Tokumura A,Tsutsumi T,Nishioka Y,Tsukatani H

更新日期：1997-03-28 00:00:00

abstract：:Monolactone (NeuAc1-9NeuAc linkage) formation of a ganglioside, GD1b, was observed at 20 degrees C on solutions ranging in concentration from 0.008 to 1.7 mM and in pH from 2 to 8.1, by following the change of ellipicity at 235 nm, where lactonized gangliosides showed a strong Cotton effect. The lactonization was foun...

journal_title：Chemistry and physics of lipids

authors： Tsuda M,Terabayashi T,Kawanishi Y

更新日期：1994-03-31 00:00:00

abstract：:Cardiolipins (CLs) are important biologically for their unique role in biomembranes that couple phosphorylation and electron transport like bacterial plasma membranes, chromatophores, chloroplasts and mitochondria. CLs are often tightly coupled to proteins involved in oxidative phosphorylation. The first step in under...

journal_title：Chemistry and physics of lipids

authors： Boscia AL,Treece BW,Mohammadyani D,Klein-Seetharaman J,Braun AR,Wassenaar TA,Klösgen B,Tristram-Nagle S

更新日期：2014-02-01 00:00:00