Abstract：
:Parkinson's disease is caused due to free radical generation in dopamine neurons leading to oxidative stress induced damage. The aim of this work was to ameliorate the free radical induced oxidative stress in rats by using TPGS (Tocopheryl polyethylene glycol 1000 succinate) loaded rutin nanoemulsion after oral administration. For this purpose, pharmacokinetic and pharmacodynamics studies were performed in albino wistar rats. Various behavioural tests (photoactometer test, rota rod, akinesia and catalepsy) and biochemical estimations for determination of GSH, TBARS and SOD were carried out. The results showed an increase in relative bioavailability of rutin after oral administration of nanoemulsion as compared to pure drug suspension. The AUC and Cmax of rutin nanoemulsion after oral administration were 1.8-fold and 1.9-fold higher than those of drug suspension respectively. Pharmacodynamic studies have shown good results with the rutin nanoemulsion than pure drug suspension. The rats treated with the rutin nanoemulsion exhibited significantly greater locomotor activity, better muscle coordination and improvement in cataleptic behaviour than the normal and haloperidol-induced rats (p < 0.001).Treatment with rutin suspension and rutin nanoemulsion helped in improving the stressed condition by increasing the levels of GSH, SOD and decrease in MDA levels in the brain. Anticancer activity was observed in a dose-dependent manner from 1 to 100 μg/ml. IC50 values for rutin suspension and rutin NE were found to be 36.7 and 25.4 μg/ml respectively. The rutin nanoemulsion has proven to be beneficial in ameliorating oxidative stress.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Sharma S,Rabbani SA,Narang JK,Hyder Pottoo F,Ali J,Kumar S,Baboota Sdoi
10.1016/j.chemphyslip.2020.104890subject
Has Abstractpub_date
2020-05-01 00:00:00pages
104890eissn
0009-3084issn
1873-2941pii
S0009-3084(20)30021-9journal_volume
228pub_type
杂志文章abstract：:Recent studies have revealed that sphingomyelin (SM) is involved in metabolic syndrome and is a new target of an anti-metabolic syndrome drug. Deficiencies in the enzyme SM synthase 1 (SMS1) result in severe abnormalities, whereas deficiencies in SMS2 do not. SMS1 and SMS2 synthesize SM under similar conditions, so th...
journal_title：Chemistry and physics of lipids
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journal_title：Chemistry and physics of lipids
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journal_title：Chemistry and physics of lipids
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journal_title：Chemistry and physics of lipids
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journal_title：Chemistry and physics of lipids
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
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journal_title：Chemistry and physics of lipids
pub_type： 杂志文章
doi：10.1016/s0009-3084(99)00113-9
更新日期：2000-01-01 00:00:00
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journal_title：Chemistry and physics of lipids
pub_type： 杂志文章
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更新日期：1979-11-01 00:00:00
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journal_title：Chemistry and physics of lipids
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journal_title：Chemistry and physics of lipids
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更新日期：1998-06-01 00:00:00
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journal_title：Chemistry and physics of lipids
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更新日期：1982-12-01 00:00:00
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journal_title：Chemistry and physics of lipids
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更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Chemistry and physics of lipids
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更新日期：1977-09-01 00:00:00
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journal_title：Chemistry and physics of lipids
pub_type： 杂志文章,评审
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更新日期：2000-11-01 00:00:00
