Further studies on the inhibition of sterol biosynthesis in animal cells by 15-oxygenated sterols.

abstract：:The transformation between a gel and a fluid phase in dipalmitoyl-phosphatidylcholine (DPPC) bilayers has been simulated using a coarse grained (CG) model by cooling bilayer patches composed of up to 8000 lipids. The critical step in the transformation process is the nucleation of a gel cluster consisting of 20-80 lip...

journal_title：Chemistry and physics of lipids

authors： Marrink SJ,Risselada J,Mark AE

更新日期：2005-06-01 00:00:00

abstract：:The recently discovered marine fatty acid (+/-)-2-methoxy-13-methyltetradecanoic acid was synthesized for the first time in six steps (26% overall yield) starting from commercially available methyl 12-methyltridecanoate. The synthetic approach provided enough material to corroborate the structure of the acid, which wa...

journal_title：Chemistry and physics of lipids

authors： Carballeira NM,Cruz H,Orellano EA,González FA

更新日期：2003-12-01 00:00:00

abstract：:Parkinson's disease is caused due to free radical generation in dopamine neurons leading to oxidative stress induced damage. The aim of this work was to ameliorate the free radical induced oxidative stress in rats by using TPGS (Tocopheryl polyethylene glycol 1000 succinate) loaded rutin nanoemulsion after oral admini...

journal_title：Chemistry and physics of lipids

authors： Sharma S,Rabbani SA,Narang JK,Hyder Pottoo F,Ali J,Kumar S,Baboota S

更新日期：2020-05-01 00:00:00

abstract：:Human erythrocyte band 3 reconstituted into phospholipid vesicles has been used for studying the interaction of interdigitated lipid bilayer with an integral membrane protein. The interdigitated gel phase in DPPG/band 3 or DPPG/DMPC/band 3 systems was induced with polymyxin B (PMB) or Tris+. The phase transitions of t...

journal_title：Chemistry and physics of lipids

authors： Wang PY,Lu JZ,Chen JW,Hwang F

更新日期：1994-03-01 00:00:00

abstract：:The 17-propanamide derivatives of diastereomeric Δ(14)-17α- and 17β-estradiols, the potential candidates of a 17β-hydroxysteroid dehydrogenase (17β-HSD) inhibitor, were synthesized in 11 steps from estrone. The principal reactions employed involved in (1) conversion of estrone to the corresponding Δ(14)-estrone, (2) G...

journal_title：Chemistry and physics of lipids

authors： Iida T,Ogawa S,Tamegai H,Adachi Y,Saito H,Ikegawa S,Konishi H,Takagi A,Matsuzaki T

更新日期：2011-02-01 00:00:00

abstract：:Among the structurally diverse collection of lipids that comprise the membrane lipidome, polyunsaturated phospholipids are particularly vulnerable to oxidation. The role of α-tocopherol (vitamin E) is to protect this influential class of membrane phospholipid from oxidative damage. Whether lipid-lipid interactions pla...

journal_title：Chemistry and physics of lipids

authors： Cavazos AT,Kinnun JJ,Williams JA,Wassall SR

更新日期：2020-09-01 00:00:00

abstract：:We examine the effects of cholesterol (Chol) on the mechanical properties of membranes consisting of 16:0/18:1 POPC lipid and of lipids with conjugated linoleic acid (CLA), cis-9/trans-11 CLA (C9T11) and trans-10/cis-12 CLA (T10C12). Atomistic molecular dynamics (MD) simulations of POPC-Chol and CLA-Chol mixtures at v...

journal_title：Chemistry and physics of lipids

authors： Khelashvili G,Johner N,Zhao G,Harries D,Scott HL

更新日期：2014-02-01 00:00:00

abstract：:The stimulatory, cytostatic and cytotoxic effects of polyunsaturated fatty acids, prostaglandins, thromboxanes, hydroperoxy fatty acids, hydroxy fatty acids and leukotrienes on normal and tumor cells are described. Their effects are related to the ability of the cells to undergo lipid peroxidation. The significance of...

journal_title：Chemistry and physics of lipids

authors： Bégin ME

更新日期：1987-11-01 00:00:00

abstract：:In the first part of this article, chemical and physical stability of aqueous liposome dispersions have been addressed. Chemical stability of phospholipids has been considered in two parts: oxidation and hydrolysis. Major attention has been paid to hydrolysis kinetics of phospholipids as a function of pH, temperature,...

journal_title：Chemistry and physics of lipids

authors： Grit M,Crommelin DJ

更新日期：1993-09-01 00:00:00

abstract：:(1) An analysis has been conducted of the lipids present in three obligately anaerobic bacteria isolated from the ovine rumen belonging to the genus Butyrivibrio. Two of these organisms are rich in phospholipase (A1 + A2) activity, and appear to be different strains of the species fibrisolvens. (2) The only N-containi...

journal_title：Chemistry and physics of lipids

authors： Clarke NG,Hazlewood GP,Dawson RM

更新日期：1976-10-01 00:00:00

abstract：:Ionic properties of didodecanoylphosphatidylglycerol (C12PG), didodecanolyphosphatidyl-l'-propanol (C12PP), di-(12-methyl, 13-methyl)-pentadecanoylphosphatidylglycerols (C15PG) and dihexadecanoylphosphatidylglycerol (C16PG) have been studied at the air-water interface using titration experiments at constant ionic stre...

journal_title：Chemistry and physics of lipids

authors： Sacré MM,Tocanne JF

更新日期：1977-04-01 00:00:00

abstract：:A polymorphic variation of sialic acid species of sialosyllactosylceramide was found in dog erythrocytes. The analysis of the glycolipids in the erythrocytes of the individual dogs in a family of a Japanese breed of dog, Shiba-Inu, showed that the expression of sialosyllactosylceramide containing N-glycolylneuraminic ...

journal_title：Chemistry and physics of lipids

authors： Yamakawa T,Suzuki A,Hashimoto Y

更新日期：1986-12-15 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis....

journal_title：Chemistry and physics of lipids

authors： Shirey CM,Ward KE,Stahelin RV

更新日期：2016-10-01 00:00:00

abstract：:A simplified procedure for lipid digestion, well suited for handling a large number of samples, was used to analyze a variety of common phospholipids. This procedure involves digestion of phospholipids in perchloric acid at 130 degrees C with minimal sample manipulation. For all lipids tested, complete destruction, ne...

journal_title：Chemistry and physics of lipids

authors： Mrsny RJ,Volwerk JJ,Griffith OH

更新日期：1986-01-01 00:00:00

abstract：:Amphotericin B (AmB) is the most effective antibiotic used in the treatment of systemic fungal infections. It is generally thought that the activity of this drug results from its interaction with ergosterol, the main sterol of fungi membranes. However, AmB also interacts with cholesterol, the major sterol of mammal me...

journal_title：Chemistry and physics of lipids

authors： Barwicz J,Tancrède P

更新日期：1997-02-28 00:00:00

abstract：:The polymorphic behavior of three series of tris-homoacyl (C14:0, C16:0 and C18:0) cyclopentane-1,2,3-triol analogs of the natural saturated triglycerides has been studied using differential thermal analysis, Fourier transform infrared spectroscopy, and X-ray diffraction. It was found that the triglyceride analogs der...

journal_title：Chemistry and physics of lipids

authors： Greenwald SM,Hancock AJ,Sable HZ,D'Esposito L,Koenig JL

更新日期：1977-03-01 00:00:00

abstract：:Melatonin and its structural analogues display antioxidant activity in vivo but their activity in model membranes is not very well known. In this study, we have investigated the antioxidant capacity of melatonin and structural analogues on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. Th...

journal_title：Chemistry and physics of lipids

authors： Fagali N,Catalá A

更新日期：2011-10-01 00:00:00

abstract：:Mycobacteria are intracellular pathogens that can invade and survive within host macrophages. Mycobacterial infections remain a major cause of mortality and morbidity worldwide, with serious concerns of emergence of multi and extensively drug-resistant tuberculosis. While significant advances have been made in identif...

journal_title：Chemistry and physics of lipids

authors： Viswanathan G,Jafurulla M,Kumar GA,Raghunand TR,Chattopadhyay A

更新日期：2018-07-01 00:00:00

abstract：:Monitoring bile acids as signal molecules in combination with a bile acid synthesis marker and the FXR regulator fibroblast growth factor 19 (FGF19), this study addresses significant postprandial changes. The efficacy of the different pathways to regulate bile acid synthesis through short heterodimer partner (SHP) dep...

journal_title：Chemistry and physics of lipids

authors： Matysik S,Martin J,Bala M,Scherer M,Schäffler A,Schmitz G

更新日期：2011-09-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in a variety of receptor-stimulated cell responses. Stimulation of receptors possessing (or coupling to) protein-tyrosine kinase activates heterodimeric PI 3-kinases, which consist of an 85-kDa regulatory subunit (p85) containing Src-homology...

journal_title：Chemistry and physics of lipids

authors： Katada T,Kurosu H,Okada T,Suzuki T,Tsujimoto N,Takasuga S,Kontani K,Hazeki O,Ui M

更新日期：1999-04-01 00:00:00

abstract：:Pulmonary surfactant is a lipid-protein complex, synthesized and secreted by the respiratory epithelium of lungs to the alveolar spaces, whose main function is to reduce the surface tension at the air-liquid interface to minimize the work of breathing. The activity of surfactant at the alveoli involves three main proc...

journal_title：Chemistry and physics of lipids

authors： Serrano AG,Pérez-Gil J

更新日期：2006-06-01 00:00:00

abstract：:Myeloperoxidase released from stimulated neutrophils is able to produce hypochlorous and hypobromous acids. The composition of the reaction products of the interaction of hypohalous acid with double bonds of phosphatidylcholines was analysed by matrix-assisted laser desorption/ionisation time-of-flight mass spectromet...

journal_title：Chemistry and physics of lipids

authors： Spalteholz H,Wenske K,Panasenko OM,Schiller J,Arnhold J

更新日期：2004-04-01 00:00:00

abstract：:We investigated the effect of pegylation on the physical stability, morphology and membrane integrity of arsonoliposomes. Arsonoliposomes composed of distearoylglycerophosphocholine (DSPC), cholesterol (Chol) and the palmitoyl side chain arsonolipid (with concentrations ranging from 0 mol% [DSPC/Chol vesicles] to 53 m...

journal_title：Chemistry and physics of lipids

authors： Piperoudi S,Fatouros D,Ioannou PV,Frederik P,Antimisiaris SG

更新日期：2006-02-01 00:00:00

abstract：:The objective of this work was to examine the interaction of cholesterol with both phosphatidylcholines, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and sphingomyelins, N-oleoyl-D-sphingomyelin (O-SPM) or N-palmitoyl-D-sphingomyelin (P-SPM), in monolay...

journal_title：Chemistry and physics of lipids

authors： Mattjus P,Slotte JP

更新日期：1996-06-17 00:00:00

abstract：:Anandamide (N-arachidonoylethanolamine) has been identified as an endogenous ligand of the G-protein coupled cannabinoid CB(1) receptor. Recent studies have postulated the existence of carrier-mediated anandamide transport which is involved in the termination of the biological effects of anandamide. A membrane bound a...

journal_title：Chemistry and physics of lipids

authors： Reggio PH,Traore H

更新日期：2000-11-01 00:00:00

abstract：:Enkephalins are pentapeptides found in the human nervous system, where they are involved in the relief of pain. The interaction of these neuropeptides with the nerve cell membranes would be a key-step in the receptor binding. We have used both Fourier-transform infrared and solid-state NMR spectroscopies to shed light...

journal_title：Chemistry and physics of lipids

authors： Marcotte I,Ouellet M,Auger M

更新日期：2004-02-01 00:00:00

abstract：:The work presented here demonstrates that the phenomenon of spontaneous vesiculation is not restricted to charged lipids and lipid mixtures, but occurs also in isoelectric phospholipid mixtures consisting of egg phosphatidylcholine (EPC) and egg lysophosphatidylcholine (lyso-EPC). 1H high-resolution NMR and freeze-fra...

journal_title：Chemistry and physics of lipids

authors： Hauser H

更新日期：1987-05-01 00:00:00

abstract：:Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3+-dioxygen-Fe2+ complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, are described and discussed ...

journal_title：Chemistry and physics of lipids

authors： Minotti G,Aust SD

更新日期：1987-07-01 00:00:00

abstract：:The effect of lauric acid and low-HLB sucrose esters (L-195, S170) on the isothermal crystallization of coconut oil was investigated by differential scanning calorimetry. The fundamental crystallization parameters, such as induction time of nucleation and crystallization rate, were obtained by using the Gompertz equat...

journal_title：Chemistry and physics of lipids

authors： Chaleepa K,Szepes A,Ulrich J

更新日期：2010-05-01 00:00:00

abstract：:Fourier transform infrared (FTIR) and time-resolved fluorescence spectroscopy have been employed to examine the structural dynamics of lipid fatty acyl chains and lipid/water interfacial region of a binary lipid mixture containing unsaturated phosphatidylethanolamine (PE) and diacylglycerol (DG). Infrared vibrational ...

journal_title：Chemistry and physics of lipids

authors： Chen SY,Cheng KH

更新日期：1990-12-01 00:00:00