Interaction of peptides with binary phospholipid membranes: application of fluorescence methodologies.

abstract：:Lipoic acid-substituted phospholipids were synthesized from phosphatidyl cholines by exchanging the choline residue with a glycol group using phospholipase D, forming phosphatidylglycols, and coupling of lipoic acid (1,2-dithiolane-3-pentanoic acid) to the residual glycol hydroxyl group by esterification. The thermotr...

journal_title：Chemistry and physics of lipids

authors： Pax H,Blume A

更新日期：1993-11-01 00:00:00

abstract：:Cardiolipins (CLs) are ancient and unusual dimeric phospholipids localized in the plasma membrane of bacteria and in the inner mitochondrial membrane of eukaryotes. In mitochondria, two types of asymmetries--trans-membrane and molecular--are essential determinants of CL functions. In this review, we describe CL-based ...

journal_title：Chemistry and physics of lipids

authors： Kagan VE,Chu CT,Tyurina YY,Cheikhi A,Bayir H

更新日期：2014-04-01 00:00:00

abstract：:The influence of the temperature on the adsorption of monomeric and micellar solutions of the anionic surfactant sodium dodecyl sulfate (SDS) on phosphatidylcholine (PC) liposomes was investigated using the fluorescent probe 2-(p-toluidinyl)-naphthalene-6-sodium sulfonate (TNS). The number of adsorbed molecules was qu...

journal_title：Chemistry and physics of lipids

authors： Cócera M,López O,Estelrich J,Parra JL,de la Maza A

更新日期：2003-06-01 00:00:00

abstract：:Alpha-tocopherol was reacted with 1-palmitoyl-2-[(9Z,11E)-(S)-13-hydroperoxy-9,11-octadecadienoyl]-3-sn-phosphatidylcholine (13-PLPC-OOH) in the presence of a lipid-soluble iron chelate, Fe(III) acetylacetonate, in methanol at 37 degrees C. The reaction product was isolated and identified as a mixture of 1-palmitoyl-2...

journal_title：Chemistry and physics of lipids

authors： Yamauchi R,Ozaki K,Shimoyamada M,Kato K

更新日期：2002-02-01 00:00:00

abstract：:Ceriporiopsis subvermispora is a selective white-rot fungus that secretes alk(en)ylitaconic acids named ceriporic acids, known as ion redox silencers. In this study, we analysed a series of extracellular lipid-related metabolites produced by the fungus and found that a wide variety of ceriporic acids and fatty acids, ...

journal_title：Chemistry and physics of lipids

authors： Nishimura H,Murayama K,Watanabe T,Honda Y,Watanabe T

更新日期：2012-01-01 00:00:00

abstract：:20-hydroxycholesterol is a signaling oxysterol with immunomodulating functions and, thus, structural analogues with reporter capabilities could be useful for studying and modulating the cellular processes concerned. We have synthesized three new 20-hydroxycholesterol-like pregn-5-en-3β-ol derivatives with fluorescent ...

journal_title：Chemistry and physics of lipids

authors： Faletrov YV,Efimova VS,Horetski MS,Tugaeva KV,Frolova NS,Lin Q,Isaeva LV,Rubtsov MA,Sluchanko NN,Novikova LA,Shkumatov VM

更新日期：2020-03-01 00:00:00

abstract：:Melatonin and its structural analogues display antioxidant activity in vivo but their activity in model membranes is not very well known. In this study, we have investigated the antioxidant capacity of melatonin and structural analogues on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. Th...

journal_title：Chemistry and physics of lipids

authors： Fagali N,Catalá A

更新日期：2011-10-01 00:00:00

abstract：:Bile acids directly related to liver and intestinal function are used as indicators of hepatobiliary and intestinal diseases. Here, we have designed and realized a capillary sensory platform for the detection of bile acids using liquid crystals (LCs). LC droplets confined in micro-capillaries are homeotropically align...

journal_title：Chemistry and physics of lipids

authors： Kim HJ,Jang CH

更新日期：2017-04-01 00:00:00

abstract：:Caged ceramide analogues (C6-, C16-, C18-, C22- and C24-Cer) have been prepared by introducing a hydrophilic coumarin-based cage bearing a short polyethylene glycol (PEG) chain. (6-Bromo-7-mTEGylated-coumarin-4-yl)methyl (Btc) caged ceramide showed efficient photo-uncaging to release the parent ceramide upon direct ex...

journal_title：Chemistry and physics of lipids

authors： Kim YA,Day J,Lirette CA,Costain WJ,Johnston LJ,Bittman R

更新日期：2016-01-01 00:00:00

abstract：:Syntheses and enzymological characterization of fluorogenic substrate probes targeting secretory phospholipase A2 (sPLA2) for detection and quantitative assays are presented. Three fluorogenic phosphatidylcholine analogs PC-1, PC-2, and PC-3 each containing the duo of 7-mercapto-4-methyl-coumarin fluorophore and 2,4-d...

journal_title：Chemistry and physics of lipids

authors： Keshavarz A,Zelaya L,Singh J,Ranganathan R,Hajdu J

更新日期：2017-01-01 00:00:00

abstract：:Based on size and compositional data, models for the two major density subclasses of human serum high density lipoproteins have been developed. Descriptions of both the surface structure of the high density lipoproteins and the structure of their apolar core regions are integral parts of these models. The surface is d...

journal_title：Chemistry and physics of lipids

authors： Verdery RB,Nichols AV

更新日期：1975-04-01 00:00:00

abstract：:Determining the particle size and number of lipoprotein components found in blood plasma (HDL, LDL and VLDL) has become an important clinical tool in diagnosing risk of cardiovascular disease. Proton (1H) NMR spectroscopy methods to quantify lipoprotein particle subclasses have been advancing since NMR lineshape analy...

journal_title：Chemistry and physics of lipids

authors： Starich MR,Tang J,Remaley AT,Tjandra N

更新日期：2020-05-01 00:00:00

abstract：:Triolein, a triglyceride containing oleic acid as the only acid moiety in the glyceride molecules has been isothermally treated at 280, 300, and 325 degrees C in glass vials under nitrogen atmosphere. The products formed during the thermal treatment at each temperature have been analysed both by infrared spectrometry ...

journal_title：Chemistry and physics of lipids

authors： Christy AA,Xu Z,Harrington Pde B

更新日期：2009-03-01 00:00:00

abstract：:Copper-induced peroxidation of liposomal palmitoyllinoleoyl-phosphatidylcholine (PLPC) is inhibited by alpha-tocopherol at micromolar concentrations. In our previous study we found that when the liposomes contain phosphatidylserine (PS), nanomolar concentrations of Toc were sufficient to inhibit peroxidation. In an at...

journal_title：Chemistry and physics of lipids

authors： Gal S,Lichtenberg D,Bor A,Pinchuk I

更新日期：2007-12-01 00:00:00

abstract：:Eugenol and its related compounds are major active constituents of essential oils and have been extensively used as food flavoring agents with significant lipid peroxidation inhibition activity, highlighting the importance of understanding detailed molecular mechanisms behind their interactions with lipid bilayer. For...

journal_title：Chemistry and physics of lipids

authors： Saha S,Verma RJ

更新日期：2018-07-01 00:00:00

abstract：:The 17-propanamide derivatives of diastereomeric Δ(14)-17α- and 17β-estradiols, the potential candidates of a 17β-hydroxysteroid dehydrogenase (17β-HSD) inhibitor, were synthesized in 11 steps from estrone. The principal reactions employed involved in (1) conversion of estrone to the corresponding Δ(14)-estrone, (2) G...

journal_title：Chemistry and physics of lipids

authors： Iida T,Ogawa S,Tamegai H,Adachi Y,Saito H,Ikegawa S,Konishi H,Takagi A,Matsuzaki T

更新日期：2011-02-01 00:00:00

abstract：:Recent studies have revealed that sphingomyelin (SM) is involved in metabolic syndrome and is a new target of an anti-metabolic syndrome drug. Deficiencies in the enzyme SM synthase 1 (SMS1) result in severe abnormalities, whereas deficiencies in SMS2 do not. SMS1 and SMS2 synthesize SM under similar conditions, so th...

journal_title：Chemistry and physics of lipids

authors： Zama K,Mitsutake S,Watanabe K,Okazaki T,Igarashi Y

更新日期：2012-10-01 00:00:00

abstract：:Human serum amyloid A (SAA) is a precursor protein of AA amyloidosis and a component of high-density lipoproteins (HDLs), thus it is essential to investigate the amyloid fibril formation of SAA under a lipid environment. We used synthetic fragment peptides corresponding to the N-terminal (residues 1-27) and central (r...

journal_title：Chemistry and physics of lipids

authors： Tanaka M,Nishimura A,Takeshita H,Takase H,Yamada T,Mukai T

更新日期：2017-01-01 00:00:00

abstract：:We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five analogues on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature...

journal_title：Chemistry and physics of lipids

authors： Benesch MG,Lewis RN,Mannock DA,McElhaney RN

更新日期：2015-05-01 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis....

journal_title：Chemistry and physics of lipids

authors： Shirey CM,Ward KE,Stahelin RV

更新日期：2016-10-01 00:00:00

abstract：:Fungal infections are an important cause of morbidity and pose a serious health concern especially in immunocompromised patients. Luliconazole (LUL) is a topical imidazole antifungal drug with a broad spectrum of activity. To overcome the limitations of conventional dosage forms, LUL loaded lyotropic liquid crystallin...

journal_title：Chemistry and physics of lipids

authors： Mahmood A,Rapalli VK,Waghule T,Gorantla S,Singhvi G

更新日期：2021-01-01 00:00:00

abstract：:We consider the situation of integral membrane proteins in a lipid bilayer matrix where the size of the polar group of the protein is important in determining the lateral packing of the proteins. We represent the cross-section of the protein hydrophobic core as a hexagon moving on a lattice, and represent the projecti...

journal_title：Chemistry and physics of lipids

authors： Pink DA,Chisholm DM,Chapman D

更新日期：1988-04-01 00:00:00

abstract：:5 alpha-Cholest-8(14)-en-3 beta-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has significant hypocholesterolemic activity upon oral administration to rodents and nonhuman primates. In the present study the metabolism of the 15-ketosterol has been investigated after the oral administration of a mix...

journal_title：Chemistry and physics of lipids

authors： Pajewski TN,Brabson JS,Kisic A,Wang KS,Hylarides MD,Jackson EM,Schroepfer GJ Jr

更新日期：1989-03-01 00:00:00

abstract：:Phosphatidylserine (PS) is an aminophospholipid that is prone to glycation. In oxidative conditions, glycated PS may lead to the formation of Amadori compounds and advanced glycated end products (AGEs), which are known to accumulate in diabetic patients. Nevertheless, there have been no studies that identified product...

journal_title：Chemistry and physics of lipids

authors： Maciel E,da Silva RN,Simões C,Melo T,Ferreira R,Domingues P,Domingues MR

更新日期：2013-09-01 00:00:00

abstract：:The molecular mechanism underlying the action of local anesthetics is still elusive. Phenylethanol (PEtOH) is an ingredient of essential oils with a rose-like odor and has been used as a local anesthetic. In this work, we have explored the effect of PEtOH on thermotropic behavior and organization of dipalmitoylphospha...

journal_title：Chemistry and physics of lipids

authors： Reddy ST,Shrivastava S,Chattopadhyay A

更新日期：2018-01-01 00:00:00

abstract：:DNA interactions with the bilayers of cationic liposomes were studied using a novel model experiment: DNAs were locally injected by a micropipette to a part of a giant unilamellar vesicle. The resulting phenomena were directly observed in optical microscope. Giant unilamellar vesicles (GUVs), about 100 microm in diame...

journal_title：Chemistry and physics of lipids

authors： Angelova MI,Tsoneva I

更新日期：1999-08-01 00:00:00

abstract：:(1) An analysis has been conducted of the lipids present in three obligately anaerobic bacteria isolated from the ovine rumen belonging to the genus Butyrivibrio. Two of these organisms are rich in phospholipase (A1 + A2) activity, and appear to be different strains of the species fibrisolvens. (2) The only N-containi...

journal_title：Chemistry and physics of lipids

authors： Clarke NG,Hazlewood GP,Dawson RM

更新日期：1976-10-01 00:00:00

abstract：:The MARTINI coarse-grained model is used to gain insight into the association of WALP23 helices in three different lipid membranes: DMPC, DPPC and DOPC. Potentials of mean force describing the association of two WALP23 helices embedded in different lipid bilayers indicate no barrier of association and a stabilization ...

journal_title：Chemistry and physics of lipids

authors： Castillo N,Monticelli L,Barnoud J,Tieleman DP

更新日期：2013-04-01 00:00:00

abstract：:[4,4-2H2]-, [5,5-2H2)-, [6-2H]-, [7-2H]-, [8,8-2H2)-, [11,11-2H2]-, [14,14-2H2]- and [18,18,18-2H3]-cis,cis-octadeca-6,9-dienoic (isolinoleic) acid were synthesized by supplementing cultures of the protozoan Tetrahymena with the corresponding deuterated cis-octadeca-9-enoic (oleic) acids. The cultures were harvested, ...

journal_title：Chemistry and physics of lipids

authors： Baenziger JE,Smith IC,Hill RJ

更新日期：1990-04-01 00:00:00

abstract：:The melon, the echolocation organ of the striped dolphin (Stenella coeruleoalba), was investigated by morphological and high-resolution (13)C nuclear magnetic resonance (NMR) methods, in order to characterize structure and composition gradient at the histological and molecular level. Morphological analysis showed that...

journal_title：Chemistry and physics of lipids

authors： Scano P,Maxia C,Maggiani F,Crnjar R,Lai A,Sirigu P

更新日期：2005-03-01 00:00:00