Abstract:
:The permeability of liposomes to water, glucose, Ca2+ and alkaline cations was monitored by recording the change in absorbance at 450 nm using a rapid reaction stopped-flow spectrophotometer. Liposomes were prepared with egg phosphatidylcholine and concentrations of dolichol ranging from 0.1% to 9% (w/w). Net permeability of phosphatidylcholine bilayers to alkaline cations was induced by the incorporation of dolichol. This effect was not observed in the case of non-charged solutes like glucose or in that of alkaline earth cations such as calcium. Permeation of K+ was significantly increased above the phase transition temperature. These results suggest that dolichols may play a role in biological membranes, besides the well-known glycosyl carrier function in the biosynthesis of glycoproteins.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Boscoboinik DO,Feliz M,Disalvo EA,Belocopitow Edoi
10.1016/0009-3084(85)90028-3subject
Has Abstractpub_date
1985-11-01 00:00:00pages
343-52issue
4eissn
0009-3084issn
1873-2941pii
0009-3084(85)90028-3journal_volume
38pub_type
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journal_title:Chemistry and physics of lipids
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journal_title:Chemistry and physics of lipids
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:Chemistry and physics of lipids
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