Abstract:
:Aqueous dispersions of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, on cooling below the chain melting temperature, form hollow cylindrical structures known as 'tubules'. We have studied the formation of tubules in methanol/water, ethanol/water and n-propanol/water. For each alcohol, there is a defined window of alcohol/water ratios in which the lipid precipitates with the tubule morphology. As the chain length of alcohol is increased, the window shifts towards lower alcohol fraction. Light scattering studies show that at very low lipid concentrations the tubules self-assemble directly from the isotropic phase where as for lipid concentrations greater than 4 mg/ml an intermediate L alpha phase is observed. These results indicate that the mechanism of tubule formation may be dependent on lipid concentration.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Ratna BR,Baral-Tosh S,Kahn B,Schnur JM,Rudolph ASdoi
10.1016/0009-3084(92)90021-gsubject
Has Abstractpub_date
1992-11-01 00:00:00pages
47-53issue
1-2eissn
0009-3084issn
1873-2941pii
0009-3084(92)90021-Gjournal_volume
63pub_type
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