Abstract：
:The growth of cationic lipid dioctadecyldimethylammonium bromide (DODAB) toward bilayer lipid membrane (BLM) by solution spreading on cleaved mica surface was studied by atomic force microscopy (AFM). Bilayer of DODAB was formed by exposing mica to a solution of DODAB in chloroform and subsequently immersing into potassium chloride solution for film developing. AFM studies showed that at the initial stage of the growth, the adsorbed molecules exhibited the small fractal-like aggregates. These aggregates grew up and expanded laterally into larger patches with time and experienced from monolayer to bilayer, finally a close-packed bilayer film (5.4+/-0.2 nm) was approached. AFM results of the film growth process indicated a growth mechanism of nucleation, growth and coalescence of dense submonolayer, it revealed the direct information about the film morphology and confirmed that solution spreading was an effective technique to prepare a cationic bilayer in a short time.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Wang L,Song Y,Han X,Zhang B,Wang Edoi
10.1016/s0009-3084(02)00195-0subject
Has Abstractpub_date
2003-04-01 00:00:00pages
177-85issue
2eissn
0009-3084issn
1873-2941pii
S0009308402001950journal_volume
123pub_type
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