当前位置： SCI文献检索 > CHEMISTRY AND PHYSICS OF LIPIDS期刊下所有文献 > Protein-lipid interactions and surface activity in the pulmonary surfactant system.

Protein-lipid interactions and surface activity in the pulmonary surfactant system.

Abstract：

:Pulmonary surfactant is a lipid-protein complex, synthesized and secreted by the respiratory epithelium of lungs to the alveolar spaces, whose main function is to reduce the surface tension at the air-liquid interface to minimize the work of breathing. The activity of surfactant at the alveoli involves three main processes: (i) transfer of surface active molecules from the aqueous hypophase into the interface, (ii) surface tension reduction to values close to 0 mN/m during compression at expiration and (iii) re-extension of the surface active film upon expansion at inspiration. Phospholipids are the main surface active components of pulmonary surfactant, but the dynamic behaviour of phospholipids along the breathing cycle requires the necessary participation of some specific surfactant associated proteins. The present review summarizes the current knowledge on the structure, disposition and lipid-protein interactions of the hydrophobic surfactant proteins SP-B and SP-C, the two main actors participating in the surface properties of pulmonary surfactant. Some of the methodologies currently used to evaluate the surface activity of the proteins in lipid-protein surfactant preparations are also revised. Working models for the potential molecular mechanism of SP-B and SP-C are finally discussed. SP-B might act in surfactant as a sort of amphipathic tag, directing the lipid-protein complexes to insert and re-insert very efficiently into the air-liquid interface along successive breathing cycles. SP-C could be essential to maintain association of lipid-protein complexes with the interface at the highest compressed states, at the end of exhalation. The understanding of the mechanisms of action of these proteins is critical to approach the design and development of new clinical surfactant preparations for therapeutical applications.

journal_name

Chem Phys Lipids

journal_title

Chemistry and physics of lipids

authors

Serrano AG,Pérez-Gil J

doi

10.1016/j.chemphyslip.2006.02.017

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

105-18

issue

1-2

eissn

0009-3084

issn

1873-2941

pii

S0009-3084(06)00028-4

journal_volume

141

pub_type

杂志文章,评审

在线工具

Protein-lipid interactions and surface activity in the pulmonary surfactant system.