Abstract:
:Inverted cubic and isotropic phases have been observed in phospholipid and glycolipid systems. These phases exhibit characteristic morphologies in freeze-fracture electron micrographs, isotropic 31P-NMR resonances and (in some cases) cubic X-ray diffraction patterns. It is proposed here that these phases may form from the same intermediates that are involved in lamellar/inverted hexagonal (L alpha/HII) phase transitions, and that it is possible that these cubic and isotropic phases are metastable. According to a kinetic theory of L alpha/HII phase transitions, intermediates in such transitions can form structures known as interlamellar attachments (ILAs). It is shown that ILAs should form in large numbers during L alpha/HII transitions in systems like those reported to form inverted cubic or isotropic structures. ILAs cannot readily assemble into either the HII phase or well-ordered arrays of L alpha phase bilayers, and represent a kinetic trap for intermediates in L alpha/HII transitions (although it is possible that they are marginally more stable in a thermodynamic sense than the L alpha phase in a small temperature range below TH). It is also shown that arrays of ILAs should form metastable arrays with the same morphology and isotropic 31P-NMR resonances that are observed in isotropic and inverted cubic states. In particular, under some circumstances ILAs will assemble into a structure identical to the bicontinuous inverted cubic phase previously described in monoglycerides and very similar in morphology to structures observed in phospholipid systems. Finally, since isotropic and cubic states form from ILAs, which also can mediate fusion of unilamellar vesicles, unilamellar vesicles should fuse to at least some extent under the same conditions in which multilamellar samples of the same lipid form isotropic or inverted cubic states. This correlation has been observed.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Siegel DPdoi
10.1016/0009-3084(86)90087-3subject
Has Abstractpub_date
1986-12-31 00:00:00pages
279-301issue
4eissn
0009-3084issn
1873-2941pii
0009-3084(86)90087-3journal_volume
42pub_type
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journal_title:Chemistry and physics of lipids
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journal_title:Chemistry and physics of lipids
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doi:10.1016/0009-3084(83)90027-0
更新日期:1983-11-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章,评审
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更新日期:1993-09-01 00:00:00
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更新日期:1996-03-29 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0009-3084(76)90042-6
更新日期:1976-11-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/0009-3084(88)90051-5
更新日期:1988-08-01 00:00:00
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doi:10.1016/j.chemphyslip.2016.02.008
更新日期:2016-03-01 00:00:00
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doi:10.1016/j.chemphyslip.2011.10.001
更新日期:2012-01-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/0009-3084(79)90055-0
更新日期:1979-09-01 00:00:00
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journal_title:Chemistry and physics of lipids
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更新日期:2018-12-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.chemphyslip.2016.06.004
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/j.chemphyslip.2006.02.014
更新日期:2006-06-01 00:00:00
abstract::The effects of Ca2+ on rotational and translational diffusion of lipids in multilamellar dimyristoylphosphatidylcholine (DMPC)-water systems were investigated by time-resolved phosphorescence anisotropy steady-state fluorescence polarization and fluorescence recovery after photobleaching (FRAP) experiments. Above the ...
journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/0009-3084(86)90021-6
更新日期:1986-10-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/0009-3084(86)90080-0
更新日期:1986-06-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/j.chemphyslip.2007.04.005
更新日期:2007-08-01 00:00:00
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/0009-3084(91)90064-i
更新日期:1991-08-01 00:00:00
abstract::Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence demonstrates that CB(1) cannabinoid receptor activation inhibits pain responses. Recently, the synthesis of CB(2) cannabinoid receptor-selective agonists has allowed testing whether CB(2) receptor activation inhibits pain. CB(2) re...
journal_title:Chemistry and physics of lipids
pub_type: 杂志文章,评审
doi:10.1016/s0009-3084(02)00155-x
更新日期:2002-12-31 00:00:00
abstract::The synthesis and self-assembling properties of a model compound in a new class of cationic phospholipids with a highly unsaturated conjugated fatty acid are described. In addition, the potential of this new lipid as a nucleic acid carrier was evaluated through lipoplex formulations employing 1,2-dioleoyl-sn-glycero-3...
journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/j.chemphyslip.2013.03.002
更新日期:2013-05-01 00:00:00
abstract::The fertilising ability of human spermatozoa may be impaired by inflammations of the genital tract, although details of these processes are still unknown. Hypochlorous acid (HOCl), an important product of myeloperoxidase released from stimulated neutrophils, induces a concentration-dependent increase in externalisatio...
journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
doi:10.1016/j.chemphyslip.2005.02.015
更新日期:2005-06-01 00:00:00