Molecular species analysis of lipids by metastable ion mass spectrometry.

abstract：:A series of polyprenyl phosphates with modified structure of polyprenyl residue was prepared through phosphorylation of polyprenyl trichloroacetimidates with phosphoric acid. Interaction of polyprenols with tetra-n-butylammonium dihydrogen phosphate and trichloroacetonitrile was found to represent a very efficient, si...

journal_title：Chemistry and physics of lipids

authors： Danilov LL,Druzhinina TN,Kalinchuk NA,Maltsev SD,Shibaev VN

更新日期：1989-11-01 00:00:00

abstract：:The work presented here demonstrates that the phenomenon of spontaneous vesiculation is not restricted to charged lipids and lipid mixtures, but occurs also in isoelectric phospholipid mixtures consisting of egg phosphatidylcholine (EPC) and egg lysophosphatidylcholine (lyso-EPC). 1H high-resolution NMR and freeze-fra...

journal_title：Chemistry and physics of lipids

authors： Hauser H

更新日期：1987-05-01 00:00:00

abstract：:The mass spectra of a number of C-4alpha- and C-4beta-alkylated cholestan-3beta, 5alpha-diols have been found to contain an intense ion at m/e 332. the corresponding 6beta-alkylated (R) cholestan-3beta, 5alpha-diols exhibit an abundant ion at m/e 331 + R. The mass spectra of cholestan-5alpha-ol and cholestan-3beta, 5a...

journal_title：Chemistry and physics of lipids

authors： Knapp FF,Wilson MS,Schroepfer GJ Jr

更新日期：1976-02-01 00:00:00

abstract：:The present study is aimed to characterize the electrostatic parameters of oil in water emulsion droplets composed of MCT (medium chain triglycerides), PL (phospholipids) and Poloxamer and containing increasing concentrations of the cationic lipid oleylamine (OA), in Hepes 20 mM pH 7.4. The initial zeta-potential data...

journal_title：Chemistry and physics of lipids

authors： Rabinovich-Guilatt L,Couvreur P,Lambert G,Goldstein D,Benita S,Dubernet C

更新日期：2004-08-01 00:00:00

abstract：:The chemical syntheses of a number of C27 15-oxygenated sterols and their derivatives have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in animal cells in culture. Described herein are chemical syntheses of 3 alpha-benzoyloxy-5 alpha-cholest-8(14)-en-15-one, 5 alpha-chol...

journal_title：Chemistry and physics of lipids

authors： Schroepfer GJ Jr,Parish EJ,Kandutsch AA

更新日期：1979-11-01 00:00:00

abstract：:In this report we have investigated the differences in the uptake and metabolization of exogenous GM1 by human fibroblasts, as a function of its supramolecular organization in solution. For this we used a tritium labelled GM1, given alone or inserted in dispersions of phosphatidylcholine (PC) or sulphatide. The additi...

journal_title：Chemistry and physics of lipids

authors： Giglioni A,Chigorno V,Pitto M,Valsecchi M,Palestini P,Ghidoni R

更新日期：1990-08-01 00:00:00

abstract：:Triolein, a triglyceride containing oleic acid as the only acid moiety in the glyceride molecules has been isothermally treated at 280, 300, and 325 degrees C in glass vials under nitrogen atmosphere. The products formed during the thermal treatment at each temperature have been analysed both by infrared spectrometry ...

journal_title：Chemistry and physics of lipids

authors： Christy AA,Xu Z,Harrington Pde B

更新日期：2009-03-01 00:00:00

abstract：:Cold atmospheric plasma (CAP) is an emerging source for the locally defined delivery of reactive species, and its clinical potential has been identified in the control of inflammatory processes, such as acute and chronic wounds, or cancerous lesions. Lipids, due to their localization and chemical structure as ideal ta...

journal_title：Chemistry and physics of lipids

authors： Striesow J,Lackmann JW,Ni Z,Wenske S,Weltmann KD,Fedorova M,von Woedtke T,Wende K

更新日期：2020-01-01 00:00:00

abstract：:Phospholipases are ubiquitous in nature and the target of significant research aiming at both their physiological roles and technical applications in e.g. the food industry. In the search for sensitive and selective phospholipase assays, we have focused on synthetic FRET (Förster resonance energy transfer) substrates....

journal_title：Chemistry and physics of lipids

authors： Piel MS,Peters GH,Brask J

更新日期：2017-01-01 00:00:00

abstract：:The 3-sulfates of the S-acyl glutathione (GSH) conjugates of five natural bile acids (cholic, chenodeoxycholic, deoxycholic, ursodeoxycholic, and lithocholic) were synthesized as reference standards in order to investigate their possible formation by a rat liver cytosolic fraction. Their structures were confirmed by p...

journal_title：Chemistry and physics of lipids

authors： Mitamura K,Hori N,Mino S,Iida T,Hofmann AF,Ikegawa S

更新日期：2012-04-01 00:00:00

abstract：:Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) or small interference RNAs (siRNAs) with their power to selectively silence any gene of interest enable the targeting of so far 'undruggable' proteins and diseases. Such RNA molecules have gained much attention from biotech and pharmaceutical companies, which led to the...

journal_title：Chemistry and physics of lipids

authors： Scheideler M,Vidakovic I,Prassl R

更新日期：2020-01-01 00:00:00

abstract：:Reported herein is the synthesis of (+)- and (-)-(1,3/2)-1-O-(phosphocholine)-2,3-O-dihexanoylcyclopentane-1,2, 3-triol. These are the enantiomers of a contrained analogue of dihexanoylphosphatidylcholine in which the glycerol backbone is replaced by all-trans cyclopentane-1,2,3-triol. Evidence is presented to demonst...

journal_title：Chemistry and physics of lipids

authors： Barlow PN,Vidal JC,Lister MD,Hancock AJ,Sigler PB

更新日期：1988-03-01 00:00:00

abstract：:The molecular mechanism underlying the action of local anesthetics is still elusive. Phenylethanol (PEtOH) is an ingredient of essential oils with a rose-like odor and has been used as a local anesthetic. In this work, we have explored the effect of PEtOH on thermotropic behavior and organization of dipalmitoylphospha...

journal_title：Chemistry and physics of lipids

authors： Reddy ST,Shrivastava S,Chattopadhyay A

更新日期：2018-01-01 00:00:00

abstract：:Platelet activating factor is one of the most potent inflammatory ether phospholipid mediators known and structurally modified analogues are of considerable interest as potential therapeutic preparations. Inspired by the proposed structure for a novel endogenous hydroxy-PAF analogue isolated recently from gingival cre...

journal_title：Chemistry and physics of lipids

authors： Karantonis HC,Pitsinos EN,Antonopoulou S,Couladouros EA,Demopoulos CA

更新日期：2005-12-01 00:00:00

abstract：:Aminoglycoside antibiotics cause aggregation but not fusion of negatively-charged liposomes at an extent proportional to their capacity to interact with acidic phospholipids (Van Bambeke et al., 1995, Eur. J. Pharmacol., 289, 321-333). To understand why aggregation is not followed by fusion, we have examined here the ...

journal_title：Chemistry and physics of lipids

authors： van Bambeke F,Mingeot-Leclercq MP,Brasseur R,Tulkens PM,Schanck A

更新日期：1996-03-29 00:00:00

abstract：:Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in a variety of receptor-stimulated cell responses. Stimulation of receptors possessing (or coupling to) protein-tyrosine kinase activates heterodimeric PI 3-kinases, which consist of an 85-kDa regulatory subunit (p85) containing Src-homology...

journal_title：Chemistry and physics of lipids

authors： Katada T,Kurosu H,Okada T,Suzuki T,Tsujimoto N,Takasuga S,Kontani K,Hazeki O,Ui M

更新日期：1999-04-01 00:00:00

abstract：:In X-ray diffraction studies of hydrated (greater than 60%) cholesterol/dioleoylphosphatidylcholine mixtures the lipid packing band showed an abrupt transition from liquid crystal-type to gel-type position and definition at a temperature which decreased progressively to almost -50 degrees C as the proportion of choles...

journal_title：Chemistry and physics of lipids

authors： Finean JB,Hutchinson AL

更新日期：1988-01-01 00:00:00

abstract：:DNA interactions with the bilayers of cationic liposomes were studied using a novel model experiment: DNAs were locally injected by a micropipette to a part of a giant unilamellar vesicle. The resulting phenomena were directly observed in optical microscope. Giant unilamellar vesicles (GUVs), about 100 microm in diame...

journal_title：Chemistry and physics of lipids

authors： Angelova MI,Tsoneva I

更新日期：1999-08-01 00:00:00

abstract：:Bovine serum albumin (BSA) undergoes a number of deteriorative changes when exposed to E-2-octenal. Reaction of BSA with E-2-octenal produced fluorescent BSA with an excitation maximum at 350 nm and emission maximum at 440 nm and promoted polymerization. Amino acid analysis of the modified BSA showed that the E-2-octe...

journal_title：Chemistry and physics of lipids

authors： Alaiz M,Barragán S

更新日期：1995-08-25 00:00:00

abstract：:A study of the vibrational behavior of five saturated monoacid triacylglycerides is performed by Raman spectroscopy at room temperature in the 3100-500 cm(-1) spectral range. The splitting of the CO stretching mode leads to conclude on the existence of two or three geometries of CO in the "knot" group OCO. The CO stre...

journal_title：Chemistry and physics of lipids

authors： Bresson S,El Marssi M,Khelifa B

更新日期：2005-04-01 00:00:00

abstract：:2-Hydroxypropane-1,3-bis(arsonic acid) after six successive reactions gives the arsinolipid 2-acyloxy-As, As'-bis[2,3-di(acyloxy)propyl]propane-1,3-diylbis(arsinic acid) in 20-40% overall yields. This arsinolipid is a non-isosteric analogue of the fully acylated cardiolipin. The R- and S-glycidol, used to create the b...

journal_title：Chemistry and physics of lipids

authors： Ioannou PV

更新日期：2002-08-01 00:00:00

abstract：:Alpha-tocopherol was reacted with 1-palmitoyl-2-[(9Z,11E)-(S)-13-hydroperoxy-9,11-octadecadienoyl]-3-sn-phosphatidylcholine (13-PLPC-OOH) in the presence of a lipid-soluble iron chelate, Fe(III) acetylacetonate, in methanol at 37 degrees C. The reaction product was isolated and identified as a mixture of 1-palmitoyl-2...

journal_title：Chemistry and physics of lipids

authors： Yamauchi R,Ozaki K,Shimoyamada M,Kato K

更新日期：2002-02-01 00:00:00

abstract：:The 17-propanamide derivatives of diastereomeric Δ(14)-17α- and 17β-estradiols, the potential candidates of a 17β-hydroxysteroid dehydrogenase (17β-HSD) inhibitor, were synthesized in 11 steps from estrone. The principal reactions employed involved in (1) conversion of estrone to the corresponding Δ(14)-estrone, (2) G...

journal_title：Chemistry and physics of lipids

authors： Iida T,Ogawa S,Tamegai H,Adachi Y,Saito H,Ikegawa S,Konishi H,Takagi A,Matsuzaki T

更新日期：2011-02-01 00:00:00

abstract：:Temperature and pH effects were studied for stability, structural organization, fluidity and permeability of vesicles from a polar lipid methanol fraction isolated from the Aeropyrum pernix. We determined the permeability of C(25,25) liposomes using fluorescence intensity of released calcein. At pH 7.0 and 9.0, and fr...

journal_title：Chemistry and physics of lipids

authors： Gmajner D,Ota A,Sentjurc M,Ulrih NP

更新日期：2011-03-01 00:00:00

abstract：:(1) An analysis has been conducted of the lipids present in three obligately anaerobic bacteria isolated from the ovine rumen belonging to the genus Butyrivibrio. Two of these organisms are rich in phospholipase (A1 + A2) activity, and appear to be different strains of the species fibrisolvens. (2) The only N-containi...

journal_title：Chemistry and physics of lipids

authors： Clarke NG,Hazlewood GP,Dawson RM

更新日期：1976-10-01 00:00:00

abstract：:Amphotericin B (AmB) is the most effective antibiotic used in the treatment of systemic fungal infections. It is generally thought that the activity of this drug results from its interaction with ergosterol, the main sterol of fungi membranes. However, AmB also interacts with cholesterol, the major sterol of mammal me...

journal_title：Chemistry and physics of lipids

authors： Barwicz J,Tancrède P

更新日期：1997-02-28 00:00:00

abstract：:Cardiolipin (CL) is a phospholipid with many unique characteristics. CL is synthesized in the mitochondria and resides almost exclusively within the mitochondrial inner membrane. Unlike most phospholipids that have two fatty acyl chains, CL possesses four fatty acyl chains resulting in unique biophysical characteristi...

journal_title：Chemistry and physics of lipids

authors： Gaspard GJ,McMaster CR

更新日期：2015-12-01 00:00:00

abstract：:Myeloperoxidase released from stimulated neutrophils is able to produce hypochlorous and hypobromous acids. The composition of the reaction products of the interaction of hypohalous acid with double bonds of phosphatidylcholines was analysed by matrix-assisted laser desorption/ionisation time-of-flight mass spectromet...

journal_title：Chemistry and physics of lipids

authors： Spalteholz H,Wenske K,Panasenko OM,Schiller J,Arnhold J

更新日期：2004-04-01 00:00:00

abstract：:Based on size and compositional data, models for the two major density subclasses of human serum high density lipoproteins have been developed. Descriptions of both the surface structure of the high density lipoproteins and the structure of their apolar core regions are integral parts of these models. The surface is d...

journal_title：Chemistry and physics of lipids

authors： Verdery RB,Nichols AV

更新日期：1975-04-01 00:00:00

abstract：:Thio analogs of platelet activating factor (PAF) are of great interest because they exhibit antineoplastic properties both in vitro and in vivo. In contrast to most known anticancer agents, these lipids appear not to act through the synthesis and function of DNA and, therefore, offer a new avenue of approaching cancer...

journal_title：Chemistry and physics of lipids

authors： Mavromoustakos T,Theodoropoulou E,Yang DP,Lin SY,Koufaki M,Makriyannis A

更新日期：1996-11-01 00:00:00