Membrane specificity of non-monotonic trends in cation-mediated injury to rapidly frozen phospholipid vesicles.

Abstract:

:Phospholipid vesicles like erythrocyte ghosts [1] have been shown to display trends in freeze-thaw injury with Group I ions which are non-monotonic in nature. That is to say, the relative extent of injury with such ions, measured as calcein release, does not follow a lyotropic series related solely to the hydrated ionic radii of these ions. By incorporation of cholesterol into the vesicles the non-monotonic nature of these trends has been shown to be highly membrane specific. Thus the non-monotonic trends in cation mediated freeze-thaw injury are shown to be independent of bulk solution properties.

journal_name

Chem Phys Lipids

authors

Brearley CA,Hodges NA,Oliff CJ

doi

10.1016/0009-3084(91)90006-w

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

183-7

issue

2

eissn

0009-3084

issn

1873-2941

pii

0009-3084(91)90006-W

journal_volume

59

pub_type

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