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Hypochlorous acid-induced stress on human spermatozoa. A model for inflammation in the male genital tract.

Abstract：

:The fertilising ability of human spermatozoa may be impaired by inflammations of the genital tract, although details of these processes are still unknown. Hypochlorous acid (HOCl), an important product of myeloperoxidase released from stimulated neutrophils, induces a concentration-dependent increase in externalisation of phosphatidylserine in ejaculated human spermatozoa as revealed by fluorescence-activated cell sorting (FACS) analysis. The increase of annexin-V binding cells starts already at about 10(-5) mol/l HOCl, while a formation of lysophosphatidylcholines as detected by matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry (MALDI-TOF MS) is only found at HOCl concentrations higher than 10(-4) mol/l. Thus, changes in lipid composition of spermatozoa are unlikely responsible for the phosphatidylcholine (PS)-externalisation. These data gave concomitant evidence that HOCl itself leads to a dramatic damage of the cell membrane. Thus, the neutrophil-derived HOCl contributes to the deterioration of spermatozoa leading to diminished fertilisation ability.

journal_name

Chem Phys Lipids

journal_title

Chemistry and physics of lipids

authors

Lessig J,Gey C,Schiller J,Süss R,Paasch U,Grunewald S,Glander HJ,Arnhold J

doi

10.1016/j.chemphyslip.2005.02.015

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

201-11

issue

2

eissn

0009-3084

issn

1873-2941

pii

S0009-3084(05)00055-1

journal_volume

135

pub_type

杂志文章

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