Electrostatics of carboxylated anionic vesicles for improving entrapment capacity.

abstract：:The interaction of monovalent cations and membrane phospholipids has a great theoretical and practical importance. Because of the very low differences between the binding forces of monovalent cations to phospholipids, the methods applied up till now did not succeed in completely elucidating this interaction. We develo...

journal_title：Chemistry and physics of lipids

authors： Cserháti T,Szögyi M

更新日期：1983-12-01 00:00:00

abstract：:Caged ceramide analogues (C6-, C16-, C18-, C22- and C24-Cer) have been prepared by introducing a hydrophilic coumarin-based cage bearing a short polyethylene glycol (PEG) chain. (6-Bromo-7-mTEGylated-coumarin-4-yl)methyl (Btc) caged ceramide showed efficient photo-uncaging to release the parent ceramide upon direct ex...

journal_title：Chemistry and physics of lipids

authors： Kim YA,Day J,Lirette CA,Costain WJ,Johnston LJ,Bittman R

更新日期：2016-01-01 00:00:00

abstract：:The synthesis and self-assembling properties of a model compound in a new class of cationic phospholipids with a highly unsaturated conjugated fatty acid are described. In addition, the potential of this new lipid as a nucleic acid carrier was evaluated through lipoplex formulations employing 1,2-dioleoyl-sn-glycero-3...

journal_title：Chemistry and physics of lipids

authors： Øpstad CL,Sliwka HR,Partali V,Elgsaeter A,Leopold P,Jubeli E,Khalique NA,Raju L,Pungente MD

更新日期：2013-05-01 00:00:00

abstract：:DNA interactions with the bilayers of cationic liposomes were studied using a novel model experiment: DNAs were locally injected by a micropipette to a part of a giant unilamellar vesicle. The resulting phenomena were directly observed in optical microscope. Giant unilamellar vesicles (GUVs), about 100 microm in diame...

journal_title：Chemistry and physics of lipids

authors： Angelova MI,Tsoneva I

更新日期：1999-08-01 00:00:00

abstract：:Low density lipoprotein (LDL) cholesterol is known to be oxidized both in vitro and in vivo giving rise to oxygenated sterols. Conflicting results, however, have been reported concerning both the nature and the relative concentrations of these compounds in oxidized human LDL. We examined the extracts obtained from Cu(...

journal_title：Chemistry and physics of lipids

authors： Malavasi B,Rasetti MF,Roma P,Fogliatto R,Allevi P,Catapano AL,Galli G

更新日期：1992-10-01 00:00:00

abstract：:Triolein, a triglyceride containing oleic acid as the only acid moiety in the glyceride molecules has been isothermally treated at 280, 300, and 325 degrees C in glass vials under nitrogen atmosphere. The products formed during the thermal treatment at each temperature have been analysed both by infrared spectrometry ...

journal_title：Chemistry and physics of lipids

authors： Christy AA,Xu Z,Harrington Pde B

更新日期：2009-03-01 00:00:00

abstract：:A complex mixture of monoacylglycerols, identified as (C30--C36) corynomycoloylglycerols was isolated from the diethyl ether/acetone-soluble lipids of Corynebacterium pseudotuberculosis. ...

journal_title：Chemistry and physics of lipids

authors： Ioneda T,Silva CL

更新日期：1979-09-01 00:00:00

abstract：:Plasmalogens (1-O-1'-alkenyl-2-acylglycerophospholipids) and to a lesser extent the 1-O-alkyl analogs are ubiquitous and in some cases major constituents of mammalian cellular membranes and of anaerobic bacteria. In archaebacteria polar lipids of the cell envelope are either diphytanylglycerolipids or bipolar macrocyc...

journal_title：Chemistry and physics of lipids

authors： Paltauf F

更新日期：1994-12-01 00:00:00

abstract：:A myriad of health benefits including the prevention of cancer and heart disease accompanies consumption of polyunsaturated fatty acids (PUFA). Of special importance is the omega-3-PUFA docosahexaenoic acid (DHA), with 22 carbons and six double bonds that constitute the most highly unsaturated fatty acid naturally occ...

journal_title：Chemistry and physics of lipids

authors： Wassall SR,Brzustowicz MR,Shaikh SR,Cherezov V,Caffrey M,Stillwell W

更新日期：2004-11-01 00:00:00

abstract：:Structural analysis, a purification scheme and stability information on a fluorescent cholesterol analogue, which has been used as a probe in several model and biological systems, are presented. The proposed structure for the fluorophore, cholestatrien-3 beta-ol, closely resembles that of cholesterol. However, problem...

journal_title：Chemistry and physics of lipids

authors： Fischer RT,Stephenson FA,Shafiee A,Schroeder F

更新日期：1984-11-01 00:00:00

abstract：:Some thermodynamic and structural aspects of propranolol-DPPC liposomes interaction were investigated by DSC and X-ray diffraction: the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until 1:1 drug/lipid molar ratio). However, the bilayer thickness increases significan...

journal_title：Chemistry and physics of lipids

authors： Albertini G,Donati C,Phadke RS,Ponzi Bossi MG,Rustichelli F

更新日期：1990-09-01 00:00:00

abstract：:The recently discovered marine fatty acid (+/-)-2-methoxy-13-methyltetradecanoic acid was synthesized for the first time in six steps (26% overall yield) starting from commercially available methyl 12-methyltridecanoate. The synthetic approach provided enough material to corroborate the structure of the acid, which wa...

journal_title：Chemistry and physics of lipids

authors： Carballeira NM,Cruz H,Orellano EA,González FA

更新日期：2003-12-01 00:00:00

abstract：:Low density lipoprotein (LDL) particles exhibit extremely complex three-dimensional structural organization which is still not understood at the molecular level. The aim of this study was to provide the experimental evidence of a direct non-covalent interaction of the protein part with the lipid matrix. The approach w...

journal_title：Chemistry and physics of lipids

authors： Kveder M,Marinić Z,Krisko A,Vikić-Topić D,Pifat G

更新日期：2006-06-01 00:00:00

abstract：:A structural studies have been performed on new complex glycolipids extracted from hog gastric mucosa by 0.4 M sodium acetate in methanol-chloroform-water, and which were purified to homogeneity by DEAE-Sephadex and Florisil column chromatography and by preparative thin-layer chromatography in three solvent systems. F...

journal_title：Chemistry and physics of lipids

authors： Slomiany BL,Slomiany A

更新日期：1977-09-01 00:00:00

abstract：:The importance of phospholipases in cellular signaling and 1-alkylglycerophosphocholine acetyltransferase in the formation of platelet-activating factor (PAF) has stimulated demand for methods to measure these enzyme activities in inflammatory cells. Most of the assays currently used rely on radiolabeled substrates. W...

journal_title：Chemistry and physics of lipids

authors： Kleuser B,Meister A,Sternfeld L,Gercken G

更新日期：1996-01-25 00:00:00

abstract：:We found that extracellular addition of 2% bovine serum albumin (BSA) to a suspension of rabbit platelets after stimulation with platelet-activating factor resulted in a biphasic extraction of [3H]1-O-alkyl-2-O-methyl (or 2-O-methylcarbamyl)-sn-glycero-3-phosphocholine. A fast phase of extraction of the phospholipid p...

journal_title：Chemistry and physics of lipids

authors： Tokumura A,Tsutsumi T,Nishioka Y,Tsukatani H

更新日期：1997-03-28 00:00:00

abstract：:The MARTINI coarse-grained model is used to gain insight into the association of WALP23 helices in three different lipid membranes: DMPC, DPPC and DOPC. Potentials of mean force describing the association of two WALP23 helices embedded in different lipid bilayers indicate no barrier of association and a stabilization ...

journal_title：Chemistry and physics of lipids

authors： Castillo N,Monticelli L,Barnoud J,Tieleman DP

更新日期：2013-04-01 00:00:00

abstract：:The effects of Ca2+ on rotational and translational diffusion of lipids in multilamellar dimyristoylphosphatidylcholine (DMPC)-water systems were investigated by time-resolved phosphorescence anisotropy steady-state fluorescence polarization and fluorescence recovery after photobleaching (FRAP) experiments. Above the ...

journal_title：Chemistry and physics of lipids

authors： Blatt E,Vaz WL

更新日期：1986-10-01 00:00:00

abstract：:Zidovudine (AZT) is an antiviral drug with moderate solubility in water. It has limited application due to its short half life in vivo and consequent requirement for frequent administrations. To solve this problem, zidovudine loaded polyvinylpyrrolidone (PVP)/stearic acid (SA)-polyethylene glycol (PEG) nanoparticles (...

journal_title：Chemistry and physics of lipids

authors： Joshy KS,Snigdha S,Anne G,Nandakumar K,Laly A P,Sabu T

更新日期：2018-01-01 00:00:00

abstract：:Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3+-dioxygen-Fe2+ complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, are described and discussed ...

journal_title：Chemistry and physics of lipids

authors： Minotti G,Aust SD

更新日期：1987-07-01 00:00:00

abstract：:The ionic transport properties, capacitance and breakdown voltage of bilayer macrovesicles made from lecithin, dodecaprenol and their mixtures have been studied. The electrical measurements showed that polyprenol in lipid bilayers increases membrane permeability and elasticity, and decreases membrane thickness. Some p...

journal_title：Chemistry and physics of lipids

authors： Janas T,Kuczera J,Chojnacki T,Krajewska-Rychlik I

更新日期：1986-03-01 00:00:00

abstract：:20-hydroxycholesterol is a signaling oxysterol with immunomodulating functions and, thus, structural analogues with reporter capabilities could be useful for studying and modulating the cellular processes concerned. We have synthesized three new 20-hydroxycholesterol-like pregn-5-en-3β-ol derivatives with fluorescent ...

journal_title：Chemistry and physics of lipids

authors： Faletrov YV,Efimova VS,Horetski MS,Tugaeva KV,Frolova NS,Lin Q,Isaeva LV,Rubtsov MA,Sluchanko NN,Novikova LA,Shkumatov VM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:In this study, we aimed to compare the serum lipid profile and fatty acid (FA) compositions of erythrocyte membrane (EM) and plasma in three different patient groups (group 1: type 2 diabetes mellitus (T2DM)+end-stage renal disease (ESRD), group 2: ESRD, group 4: T2DM) and healthy controls (group 3) simultan...

journal_title：Chemistry and physics of lipids

authors： Sertoglu E,Kurt I,Tapan S,Uyanik M,Serdar MA,Kayadibi H,El-Fawaeir S

更新日期：2014-02-01 00:00:00

abstract：:[4,4-2H2]-, [5,5-2H2)-, [6-2H]-, [7-2H]-, [8,8-2H2)-, [11,11-2H2]-, [14,14-2H2]- and [18,18,18-2H3]-cis,cis-octadeca-6,9-dienoic (isolinoleic) acid were synthesized by supplementing cultures of the protozoan Tetrahymena with the corresponding deuterated cis-octadeca-9-enoic (oleic) acids. The cultures were harvested, ...

journal_title：Chemistry and physics of lipids

authors： Baenziger JE,Smith IC,Hill RJ

更新日期：1990-04-01 00:00:00

abstract：:N-Acyl tris(hydroxymethyl)aminomethanes (N-acyl tris, NATs) are structural analogs of ceramides, which were reported to induce apoptosis either by elevation of ceramide levels or by activation of pro-apoptotic effectors that are physiological targets of ceramide. In this study, we synthesized and characterized a homol...

journal_title：Chemistry and physics of lipids

authors： D S,Ravindar C,Swamy MJ

更新日期：2018-12-01 00:00:00

abstract：:The effect of Lp(a) on lipid metabolism in cells cultured from unaffected human aortic intima has been investigated. Lp(a) isolated from the blood of healthy subjects failed to alter intracellular neutral lipid content. On the other hand, Lp(a) obtained from coronary atherosclerosis patients induced a 1.5- to 2-5-fold...

journal_title：Chemistry and physics of lipids

authors： Tertov VV,Orekhov AN

更新日期：1994-01-01 00:00:00

abstract：:Cholesterol has many functions, including those that affect biophysical properties of membranes, and is a precursor to hormone synthesis. These actions are governed by enzymatic pathways that modify the sterol nucleus or the isooctyl tail. The addition of oxygen to the cholesterol backbone produces its derivatives kno...

journal_title：Chemistry and physics of lipids

authors： Iuliano L

更新日期：2011-09-01 00:00:00

abstract：:New 1,20-substituted eicosanes carrying phosphate headgroups and readily derivatizable thiol, maleimido, and activated carboxylic ester moieties were prepared. The C20-backbone of these molecules was assembled by a halopolycarbon homologation from 1,8-dichlorooctane and 1,6-dibromohexane. 20-Mercapto- and 20-maleimido...

journal_title：Chemistry and physics of lipids

authors： Jablonkai I,Oroszlan P

更新日期：2005-01-01 00:00:00

abstract：:A series of long-chain methyl esters with vicinal oxo groups (1,2-diones; 1,2-diketones) were synthesized by potassium permanganate-based oxidation of methyl esters of mono-unsaturated fatty acids. The presence of two additional carbonyl groups may facilitate the synthesis of other derivatives. The starting materials ...

journal_title：Chemistry and physics of lipids

authors： Knothe G

更新日期：2002-05-01 00:00:00

abstract：:We performed differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectroscopic studies of the effects of cholesterol (CHOL), 7-dehydrocholeterol (7DHC) and desmosterol (DES) on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes. 7DHC a...

journal_title：Chemistry and physics of lipids

authors： Benesch MG,Lewis RN,McElhaney RN

更新日期：2015-10-01 00:00:00