Abstract:
:The recently discovered marine fatty acid (+/-)-2-methoxy-13-methyltetradecanoic acid was synthesized for the first time in six steps (26% overall yield) starting from commercially available methyl 12-methyltridecanoate. The synthetic approach provided enough material to corroborate the structure of the acid, which was recently identified in the sponge Amphimedon complanata from Aguadilla, Puerto Rico, and to test its cytotoxicity to three leukemia cell lines. The key step in the synthesis was the addition of trimethylsilyl cyanide to 12-methyltridecanal under triethylamine catalysis. Nuclear magnetic resonance data are provided for the first time for this methoxylated fatty acid and the synthetic approach utilized is of general applicability since it can be used in the synthesis of other methyl-branched 2-methoxylated fatty acids. We also report that the acid (+/-)-2-methoxy-13-methyltetradecanoic acid is cytotoxic to human chronic myelogenous leukemia K-562 (EC50=238 microM), histiocytic lymphoma U-937 (EC50=250 microM), and promielocytic leukemia HL-60 (EC50=476 microM) in RPMI 1640 medium.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Carballeira NM,Cruz H,Orellano EA,González FAdoi
10.1016/s0009-3084(03)00110-5subject
Has Abstractpub_date
2003-12-01 00:00:00pages
149-53issue
2eissn
0009-3084issn
1873-2941pii
S0009308403001105journal_volume
126pub_type
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journal_title:Chemistry and physics of lipids
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journal_title:Chemistry and physics of lipids
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