Abstract:
:We constructed a chronic oxidative stress model in which Se-deficient diet was fed to male Wister rats for 8 weeks. As expected, effects of oxidative damage, including Fe accumulation and increase in peroxidized lipids, were identified in the liver owing to the lack of glutathione peroxidase. Although the oxidative stress caused Fe accumulation in the liver, the Fe concentration in bile of the SeD rat was almost the same as that in the control rats. The constant excretion of Fe into bile supported the Fe accumulation in the liver. No differences were observed in the principal components of biliary lipids, i.e., bile acids, phospholipids, and cholesterol, between the two groups; moreover, these trends were also reflected in the plasma. Due to the trapping of reactive oxygen species, only bilirubin concentrations in the bile and plasma were decreased in the SeD group, when compared with those in the control group. Measurement of bilirubin concentration may be used as a supplemental oxidative stress marker.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Sakuma Y,Sasaki J,Futami A,Yamasaki K,Matsuoka K,Honda C,Endo K,Tsukada Mdoi
10.1016/j.chemphyslip.2007.04.005subject
Has Abstractpub_date
2007-08-01 00:00:00pages
70-6issue
2eissn
0009-3084issn
1873-2941pii
S0009-3084(07)00055-2journal_volume
148pub_type
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