Abstract:
:Small unilamellar liposomes were made of dipalmitoyl-phosphatidylcholine and dioleoyl-phosphatidylcholine, and photosensitized by a symmetrically or an asymmetrically substituted glycosilated tetraphenyl-porphyrin derivative. As differential scanning calorimetry and electron paramagnetic resonance spectroscopy (EPR) revealed these porphyrin derivatives were localized in different depth within the lipid bilayer. Both porphyrin derivatives were able to induce photoreaction and consequent structural changes in the membrane. 5-, 12-, or 16-doxyl stearic acid labeled lipid bilayers were applied and the efficiency of photoinduced reaction was followed by the decay of their EPR signal amplitude. Light dose-dependent destruction of nitroxide radical proved to be dependent on the position of spin label. In this process the porphyrin localized in closer connection with the double bond of unsaturated fatty acid was more effective. EPR signal decay was also dependent on the unsaturated fatty acid content of the liposome and the oxygen saturation of the solvent.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Voszka I,Budai M,Szabó Z,Maillard P,Csík G,Gróf Pdoi
10.1016/j.chemphyslip.2006.10.005subject
Has Abstractpub_date
2007-02-01 00:00:00pages
63-71issue
2eissn
0009-3084issn
1873-2941pii
S0009-3084(06)00166-6journal_volume
145pub_type
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journal_title:Chemistry and physics of lipids
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章
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journal_title:Chemistry and physics of lipids
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Chemistry and physics of lipids
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pub_type: 杂志文章,评审
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