Abstract:
:The activity of phytosterols on human organism includes the ability of these compounds to incorporate into membranes. In the consequence the plant sterols are able to increase total sterol concentration in membrane or/and to replace cholesterol molecules. The aim of this work was to compare the influence of both these effects on the properties of model erythrocyte membranes. Moreover, the interactions between the plant sterols (beta-sitosterol and stigmasterol) and saturated-monounsaturated phosphatidylcholine were investigated and the condensing and ordering potency of these phytocompounds on membrane phospholipids were thoroughly analyzed. It was found that the addition of the plant sterols into model membrane modifies the condensation, ordering and interactions in the system. Moreover, the replacement of mammalian sterol by phytosterol more strongly influences the model system than even a 10% increase of total sterol concentration induced by the incorporation of the plant sterol, at constant content of cholesterol. The investigated plant sterols at their lower concentration in the mixed system are of similar effect on its properties. At higher content stigmasterol was found to modify the properties of model membrane more strongly than beta-sitosterol.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Hac-Wydro Kdoi
10.1016/j.chemphyslip.2010.07.001subject
Has Abstractpub_date
2010-09-01 00:00:00pages
689-97issue
7eissn
0009-3084issn
1873-2941pii
S0009-3084(10)00323-3journal_volume
163pub_type
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