Abstract:
:Reported herein is the synthesis of (+)- and (-)-(1,3/2)-1-O-(phosphocholine)-2,3-O-dihexanoylcyclopentane-1,2, 3-triol. These are the enantiomers of a contrained analogue of dihexanoylphosphatidylcholine in which the glycerol backbone is replaced by all-trans cyclopentane-1,2,3-triol. Evidence is presented to demonstrate that the (-)-enantiomer is a substrate for phospholipase A2 (PLA2) (Crotalus atrox) while the (+)-enantiomer is not. This strict enantiomeric (and positional) specificity was exploited in conjunction with a novel application of DEAE-cellulose column chromatography, to achieve racemic resolution with an excellent yield. The constrained backbone geometry, and the experimentally accessible critical micellar concentration (CMC) of these analogues should render them useful probes for assessing the contribution of substrate conformation and flexibility to the catalytic efficiency of PLA2.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Barlow PN,Vidal JC,Lister MD,Hancock AJ,Sigler PBdoi
10.1016/0009-3084(88)90017-5subject
Has Abstractpub_date
1988-03-01 00:00:00pages
157-64issue
3eissn
0009-3084issn
1873-2941pii
0009-3084(88)90017-5journal_volume
46pub_type
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