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Binding of a cationic phenazinium dye in anionic liposomal membrane: a spectacular modification in the photophysics.

Abstract：

:Interaction of a cationic phenazinium dye, phenosafranin (PSF), with the anionic liposomal vesicle/bilayer of dimyristoyl-L-alpha-phosphatidylglycerol (DMPG) has been demonstrated using steady state and time resolved fluorescence and fluorescence anisotropy techniques. The charge transfer emission spectrum of PSF shows a dramatic modification in terms of fluorescence yield together with an appreciable hypsochromic shift in the lipid environment. The blue shift indicates a lowering in polarity inside the vesicle as compared to that in bulk water. The fluorescence and fluorescence quenching studies and micropolarity determination reveal that the cationic fluorophore has a profound binding interaction with the anionic DMPG membrane. Anisotropy study indicates the imposition of a motional restriction on the probe inside the bilayer. The electrostatic interaction between the cationic dye and the anionic lipid membrane has been argued to be the reason behind all these observations. The results could be useful in analyzing membrane organization and heterogeneity in natural membranes exploiting PSF or alike compounds as fluorescent probes.

journal_name

Chem Phys Lipids

journal_title

Chemistry and physics of lipids

authors

Bose D,Ghosh D,Das P,Girigoswami A,Sarkar D,Chattopadhyay N

doi

10.1016/j.chemphyslip.2009.10.003

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

94-101

issue

1

eissn

0009-3084

issn

1873-2941

pii

S0009-3084(09)00341-7

journal_volume

163

pub_type

杂志文章

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