A 31P study of fatigue and metabolism in human skeletal muscle with voluntary, intermittent contractions at different forces.

abstract：:The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...

journal_title：NMR in biomedicine

authors： Neil J,Miller J,Mukherjee P,Hüppi PS

更新日期：2002-11-01 00:00:00

abstract：:Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...

journal_title：NMR in biomedicine

authors： Silveri MM,Dikan J,Ross AJ,Jensen JE,Kamiya T,Kawada Y,Renshaw PF,Yurgelun-Todd DA

更新日期：2008-11-01 00:00:00

abstract：:While phase imaging with a gradient echo (GRE) sequence is popular, phase imaging with balanced steady-state free precession (bSSFP) has been underexplored. The purpose of this study was to investigate anatomical and functional phase imaging with multiple phase-cycled bSSFP, in expectation of increasing spatial covera...

journal_title：NMR in biomedicine

authors： Kim JW,Kim SG,Park SH

更新日期：2017-06-01 00:00:00

abstract：:The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three ...

journal_title：NMR in biomedicine

authors： Fernandes CC,Lanz B,Chen C,Morris PG,Salmon CG

更新日期：2020-11-02 00:00:00

abstract：:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...

journal_title：NMR in biomedicine

authors： Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

更新日期：2015-06-01 00:00:00

abstract：:Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...

journal_title：NMR in biomedicine

authors： Rao R,Nashawaty M,Fatima S,Ennis K,Tkac I

更新日期：2018-05-01 00:00:00

abstract：:Previous studies have demonstrated that using hyperpolarized [2-13 C]pyruvate as a contrast agent can reveal 13 C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-13 C]pyruvate are the result of several metabolic st...

journal_title：NMR in biomedicine

authors： Chen AP,Lau AZ,Gu YP,Schroeder MA,Barry J,Cunningham CH

更新日期：2018-01-01 00:00:00

abstract：:The leakage of metabolites from frozen and thawed tissue biopsies was measured semi-quantitatively by high-field (8.5 T) proton MRS. Human prostate and rat brain tissue specimens, frozen within 1 min of collection, lost significant and variable amounts of diagnostic metabolites immediately upon thawing. For prostate t...

journal_title：NMR in biomedicine

authors： Bourne R,Dzendrowskyj T,Mountford C

更新日期：2003-04-01 00:00:00

abstract：:A review of the theory, technology, and use of radio frequency (RF) coils for small-animal MRI is presented. It includes a brief overview of MR signal-to-noise (S/N) analysis and discussions of the various coils commonly used in small-animal MR: surface coils, linear volume coils, birdcages, and their derivatives. The...

journal_title：NMR in biomedicine

authors： Doty FD,Entzminger G,Kulkarni J,Pamarthy K,Staab JP

更新日期：2007-05-01 00:00:00

abstract：:Structural high-resolution imaging of the brainstem can be of high importance in clinical practice. However, ultra-high field magnetic resonance imaging (MRI) is still restricted in use due to limited availability. Therefore, quantitative MRI techniques (quantitative susceptibility mapping [QSM], relaxation measuremen...

journal_title：NMR in biomedicine

authors： Straub S,Knowles BR,Flassbeck S,Steiger R,Ladd ME,Gizewski ER

更新日期：2019-09-01 00:00:00

abstract：:A number of NMR spectroscopic and microscopic MRI (microMRI) techniques were used to study proton dynamics in canine tendon and articular cartilage immersed in normal saline solution (NaCl solution) and high-concentration phosphate-buffered saline (PBS) solution. In a proton CPMG experiment on tendons, the T(2) relaxa...

journal_title：NMR in biomedicine

authors： Zheng S,Xia Y

更新日期：2009-02-01 00:00:00

abstract：:The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...

journal_title：NMR in biomedicine

authors： Snaar JE,Teeuwisse WM,Versluis MJ,van Buchem MA,Kan HE,Smith NB,Webb AG

更新日期：2011-08-01 00:00:00

abstract：:Phosphorus MRSI (31 P-MRSI) using a spiral-trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunte...

journal_title：NMR in biomedicine

authors： Valkovič L,Chmelík M,Meyerspeer M,Gagoski B,Rodgers CT,Krššák M,Andronesi OC,Trattnig S,Bogner W

更新日期：2016-12-01 00:00:00

abstract：:Although diffusion MRI has shown promise for the characterization of breast cancer, it has low specificity to malignant subtypes. Higher specificity might be achieved if the effects of cell morphology and molecular exchange across cell membranes could be disentangled. The quantification of exchange might thus allow th...

journal_title：NMR in biomedicine

authors： Lasič S,Oredsson S,Partridge SC,Saal LH,Topgaard D,Nilsson M,Bryskhe K

更新日期：2016-05-01 00:00:00

abstract：:At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...

journal_title：NMR in biomedicine

authors： Marjańska M,Auerbach EJ,Valabrègue R,Van de Moortele PF,Adriany G,Garwood M

更新日期：2012-02-01 00:00:00

abstract：:We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patient...

journal_title：NMR in biomedicine

authors： Menze BH,Lichy MP,Bachert P,Kelm BM,Schlemmer HP,Hamprecht FA

更新日期：2006-08-01 00:00:00

abstract：:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...

journal_title：NMR in biomedicine

authors： Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha N

更新日期：2011-05-01 00:00:00

abstract：:With a fixed time to acquire a magnetic resonance (MR) image, time can be spent to acquire better spatial resolution with decrease in signal-to-noise ratio (SNR) or decreased resolution with increase in SNR. This resolution/SNR tradeoff at fixed time has been investigated by a visual rater study using images of ex viv...

journal_title：NMR in biomedicine

authors： Kale SC,Chen XJ,Henkelman RM

更新日期：2009-06-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhi...

journal_title：NMR in biomedicine

authors： Zhang Y,Zhao H,Qiu S,Tian J,Wen X,Miller JL,von Deneen KM,Zhou Z,Gold MS,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

journal_title：NMR in biomedicine

authors： Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

更新日期：1988-02-01 00:00:00

abstract：:Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...

journal_title：NMR in biomedicine

authors： Niess F,Fiedler GB,Schmid AI,Laistler E,Frass-Kriegl R,Wolzt M,Moser E,Meyerspeer M

更新日期：2018-06-01 00:00:00

abstract：:In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Never...

journal_title：NMR in biomedicine

authors： Kobus T,Wright AJ,Scheenen TW,Heerschap A

更新日期：2014-01-01 00:00:00

abstract：:Quantification of metabolites is a goal of many biomedical NMR studies. To obtain absolute measurements of metabolite concentrations is often both difficult and time-consuming. In this paper a method for determining metabolite concentrations directly is described and validated. It is applicable to studies of amphibian...

journal_title：NMR in biomedicine

authors： Wray S,Wilkie DR

更新日期：1992-05-01 00:00:00

abstract：:Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This st...

journal_title：NMR in biomedicine

authors： Green MA,Bilston LE,Sinkus R

更新日期：2008-08-01 00:00:00

abstract：:Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...

journal_title：NMR in biomedicine

authors： Assaf Y,Cohen Y

更新日期：1998-04-01 00:00:00

abstract：:Lung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time...

journal_title：NMR in biomedicine

authors： Bianchi A,Gobbo OL,Dufort S,Sancey L,Lux F,Tillement O,Coll JL,Crémillieux Y

更新日期：2017-11-01 00:00:00

abstract：:Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...

journal_title：NMR in biomedicine

authors： Mancini L,Davies L,Friedlos F,Falck-Miniotis M,Dzik-Jurasz AS,Springer CJ,Leach MO,Payne GS

更新日期：2009-06-01 00:00:00

abstract：:Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CM

更新日期：2020-10-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...

journal_title：NMR in biomedicine

authors： Schad LR

更新日期：2001-11-01 00:00:00