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Mechanisms of mammalian iron homeostasis.

Abstract：

:Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism, as well as for several other essential processes. Mammalian cells utilize multiple mechanisms to acquire iron. Disruption of iron homeostasis is associated with various human diseases: iron deficiency resulting from defects in the acquisition or distribution of the metal causes anemia, whereas iron surfeit resulting from excessive iron absorption or defective utilization causes abnormal tissue iron deposition, leading to oxidative damage. Mammals utilize distinct mechanisms to regulate iron homeostasis at the systemic and cellular levels. These involve the hormone hepcidin and iron regulatory proteins, which collectively ensure iron balance. This review outlines recent advances in iron regulatory pathways as well as in mechanisms underlying intracellular iron trafficking, an important but less studied area of mammalian iron homeostasis.

journal_name

Biochemistry

journal_title

Biochemistry

authors

Pantopoulos K,Porwal SK,Tartakoff A,Devireddy L

doi

10.1021/bi300752r

subject

Has Abstract

pub_date

2012-07-24 00:00:00

pages

5705-24

issue

29

eissn

0006-2960

issn

1520-4995

journal_volume

51

pub_type

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