Abstract：
:A highly optimized software for the kinetic analysis of complex chemical models is presented. The program is applied to the analysis of a vectorial biochemical reaction, where many species are linked by multiple equilibria of any order. The reaction stimulates the Ca2(+)-transport-linked ATPase reaction taking place in a suspension of vesicular fragments of isolated sarcoplasmic reticulum membranes, as described in many experimental reports. The model includes 12 reactants and intermediate chemical species, 14 kinetic constants, compartmentalization, and thermodynamic adjustment. The concentrations of all the model components, at any time, starting from a known initial condition, are calculated. The transient concentrations of the species are obtained by numerical integration of the appropriate differential equations, using an optimized version of the Runge-Kutta-Gill algorithm, with the aid of a Digital PDP11/23 computer and a standard BASIC-11 software, which could be fast and easily fitted to work with any microcomputer and/or alternative language or faster working compiled BASIC version. The errors of the calculations are evaluated.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Hecht JP,Nikonov JM,Alonso GLdoi
10.1016/0169-2607(90)90018-5subject
Has Abstractpub_date
1990-09-01 00:00:00pages
13-20issue
1eissn
0169-2607issn
1872-7565pii
0169-2607(90)90018-5journal_volume
33pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Total Variation (TV) minimization algorithms have achieved great attention due to the virtue of decreasing noise while preserving edges. The purpose of this work is to implement and evaluate two TV minimization methods in 3D. Their performance is analyzed through 3D visualization of digital bre...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105534
更新日期：2020-10-01 00:00:00
abstract：:How to distinguish 1 billion individuals by an identifier consisting of eight characters, allowing a reasonable amount of error detection or even error correction? Our solution of this problem is an optimal code over a 32-character alphabet that detects up to two errors and corrects one error as well as a transpositio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.004
更新日期：2005-07-01 00:00:00
abstract：:Several approaches, based on different assumptions and with various degree of theoretical sophistication and implementation complexity, have been developed for improving the measurement of evoked potentials (EP) performed by conventional averaging (CA). In many of these methods, one of the major challenges is the expl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00175-4
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:Coronary artery disease (CAD) is still one of the primary causes of death in the developed countries. Stress single-photon emission computed tomography is used to evaluate myocardial perfusion and ventricular function in patients with suspected or known CAD. This study sought to test data mining and machin...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105343
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Strabismus is an eye movement disorder in which shows the abnormal ocular deviation. Cover tests have mainly been used in the clinical diagnosis of strabismus for treatment. However, the whole process depends on the doctor's level of experience, which could be subjected to several factors. In t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105132
更新日期：2020-03-01 00:00:00
abstract：:The Medicare program, the largest health insurance program in the United States, is clearly at a crossroads as it enters its third decade. Historical increases in health care expenditures, plus a changing political and economic landscape, have set the groundwork for policy reform. Two basic reform strategies--reimburs...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(87)90055-1
更新日期：1987-09-01 00:00:00
abstract：:An iterative algorithm is given to correct for the zeroth and first order phase errors in NMR spectroscopy. A FORTRAN computer program is listed and two sample runs exemplified. No a priori knowledge of the existing phase errors is required. The parameters are optimised iteratively under the assumption that when the s...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90078-8
更新日期：1988-01-01 00:00:00
abstract：:Manatunga and Chen [A.K. Manatunga, S. Chen, Sample size estimation for survival outcomes in cluster-randomized studies with small cluster sizes, Biometrics 56 (2000) 616-621] proposed a method to estimate sample size and power for cluster-randomized studies where the primary outcome variable was survival time. The sa...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.11.004
更新日期：2005-04-01 00:00:00
abstract：:Model reduction techniques have shown to constitute a valuable tool for real-time simulation in surgical environments and other fields. However, some limitations, imposed by real-time constraints, have not yet been overcome. One of such limitations is the severe limitation in time (established in 500Hz of frequency fo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.06.012
更新日期：2012-01-01 00:00:00
abstract：:Optimal sampling schedule (OSS) is of great interest in biomedical experiment design, as it can improve the physiological parameter estimation precision and significantly reduce the samples required. A number of well designed algorithms and software packages have been developed, which deal with the instantaneous measu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00114-0
更新日期：2001-04-01 00:00:00
abstract：:Diabetic retinopathy (DR) is one of the most important complications of diabetes mellitus, which causes serious damages in the retina, consequently visual loss and sometimes blindness if necessary medical treatment is not applied on time. One of the difficulties in this illness is that the patient with diabetes mellit...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.06.007
更新日期：2012-08-01 00:00:00
abstract：:A microcomputer program in BASIC for predicting percentage of occurrence of electroshock-induced convulsion in mice was designed. A formula published by the author to express the mathematical relationship among the drug dose, the time, and the biological response was used in this program. Analysis of the actual, and t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90177-6
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Tomographic sequences of biomedical images are commonly used to achieve a three-dimensional visualization of the human anatomy. In some cases, the number of images contained in the sequence is limited, e.g., in low-dose computed tomography acquired on neonatal patients, resulting in a coarse an...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105525
更新日期：2020-10-01 00:00:00
abstract：:This paper briefly reviews work undertaken within the DTI-sponsored MORSE project. The Clinical Biochemistry Department of the West Middlesex University Hospital, one of the five project partners, provides clinical and laboratory services to a wide range of users. The Laboratory Information Management System used with...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90146-5
更新日期：1994-07-01 00:00:00
abstract：:In modern molecular biology, high-throughput experiments allow the simultaneous study of expression levels of thousands of biopolymers such as mRNAs, miRNAs or proteins. A typical goal of such experiments is to find molecular signatures that can distinguish between different types of tissue or that can predict a thera...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.013
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In this note we propose a nonlinear programming approach for simultaneous fitting of quantile regression models for two or more quantiles. The approach is straightforward, flexible and practical. We apply this approach to a dataset of lactic acid values from a screening dataset in childhood mal...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.10.019
更新日期：2018-01-01 00:00:00
abstract：:We have designed and implemented a human brain multi-modality database system with content-based image management, navigation and retrieval support for epilepsy. The system consists of several modules including a database backbone, brain structure identification and localization, segmentation, registration, visual fea...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.012
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To ove...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.007
更新日期：2018-02-01 00:00:00
abstract：:Diabetic retinopathy is one of the major causes of blindness in the world. Early diagnosis of this disease is vital to the prevention of visual loss. The analysis of retinal lesions such as exudates, microaneurysms and hemorrhages is a prerequisite to detect diabetic disorders such as diabetic retinopathy and macular ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.05.016
更新日期：2016-09-01 00:00:00
abstract：:Aortic valve diseases caused by the support from left ventricular assist devices (LVADs) have attracted increasing attention due to the wide application of the LVADs. However, the biomechanical effects of the working modes of LVADs on the aortic valve are still poorly understood. Hence, in this study, these biomechani...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105512
更新日期：2020-09-01 00:00:00
abstract：:Research in muscle physiology has progressed in both the volume and complexity of data examined. Dependence on manual methods to analyze and condense this amount of information can present a narrow bottleneck to the efficient completion of a study, and can compromise the reliability of the results. We designed a gener...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90161-2
更新日期：1989-04-01 00:00:00
abstract：:This paper discusses the underlying issues in the evaluation of computer systems which apply artificial intelligence in medicine. Three different levels of evaluation are described: the subjective evaluation of the research contribution of a developmental prototype, the validation of a system's knowledge and performan...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Finite element based simulation has emerged as a powerful tool to analyse the tooth strength and its fracture characteristics. The aim of this study is to compare and evaluate the fracture resistance of immature teeth reinforcement with MTA, Biodentine and Bioaggregate as an apical plug and bac...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105356
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Light sharing PET detector configuration coupled with thick light guide and Geiger-mode avalanche photodiode (GAPD) with large-area microcells was proposed to overcome the energy non-linearity problem and to obtain high light collection efficiency (LCE). METHODS:A Monte-Carlo simulation was c...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.04.007
更新日期：2016-07-01 00:00:00
abstract：:Patient survival is one of the most important measures of cancer patient care (the diagnosis and treatment of cancer). The optimal method for monitoring the progress of patient care across the full spectrum of provider settings is through the population-based study of cancer patient survival, which is only possible us...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.08.002
更新日期：2005-12-01 00:00:00
abstract：:Control of blood glucose concentration for patients in intensive care units (ICUs) has been demonstrated to be beneficial in reducing mortality and the incidence of serious complications, for both diabetic and non-diabetic patients. However, the high degree of variability and uncertainty characterizing the physiologic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.01.011
更新日期：2013-02-01 00:00:00
abstract：:Influence diagrams have been widely used as knowledge bases in medical informatics and many applied domains. In conventional influence diagrams, the numerical models of uncertainty are probability distributions associated with chance nodes and value tables for value nodes. However, when incomplete knowledge or linguis...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.11.009
更新日期：2008-04-01 00:00:00
abstract：:This paper presents an original interactive system for efficient medical image segmentation in computer aided diagnosis. The main originality concerns the method used to manage, according to an a priori topological-based structural model, regions of interest (ROIs) within which computations can be constrained. The goa...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.04.004
更新日期：2006-06-01 00:00:00
abstract：:We present three mathematical models which simulate the wound healing time for 10% oil-resin (10% OR), 10% hydroalcoholic extract (10% EH) (Copaifera langsdorffii drugs), Lanette cream (LC) and Collagenase treatments. Wound healing is a complex process consisting of inflammatory, proliferative and remodelling phases. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105915
更新日期：2020-12-26 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Fraction of Inspired Oxygen is one of the arbitrary set ventilator parameters which has critical influence on the concentration of blood oxygen. Normally mechanical ventilators providing respiratory assistance are tuned manually to supply required inspired oxygen to keep the oxygen saturation a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.04.014
更新日期：2019-07-01 00:00:00
