Abstract:
:We present three mathematical models which simulate the wound healing time for 10% oil-resin (10% OR), 10% hydroalcoholic extract (10% EH) (Copaifera langsdorffii drugs), Lanette cream (LC) and Collagenase treatments. Wound healing is a complex process consisting of inflammatory, proliferative and remodelling phases. The experiments were made on rats with wounds on their backs. The mathematical models consider the interplay among neutrophils, macrophages, which play an essential role in skin wound healing, pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines. The ordinary differential equations (ODE) models reproduce the cellular dynamics of wound healing on the skin, suggesting levels of macrophages and neutrophils cellularity, consistent with the values of total cellularity obtained in the laboratory. The partial differential equations (PDE) model replicate the dispersion along the wound radius, suggesting that the balance of the interleukins is better modelled on copaíba-based treatments (CBT). The cell density is directly influenced by neutrophils in the wound bed and by macrophages at the wound edge. It was possible to find the time for wound healing for all treatments by inserting the diffusive terms.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
de Oliveira MH,Gushiken LFS,Pellizzon CH,Mancera PFAdoi
10.1016/j.cmpb.2020.105915subject
Has Abstractpub_date
2020-12-26 00:00:00pages
105915eissn
0169-2607issn
1872-7565pii
S0169-2607(20)31748-Xjournal_volume
199pub_type
杂志文章abstract::A simple microcomputer crossover program in BASIC is designed for the purpose of drug bioequivalence studies and other related fields of statistical investigation. An illustration of the application of the program is presented to compare the bioavailability of ibuprofen when administered alone or followed by colestipo...
journal_title:Computer methods and programs in biomedicine
pub_type: 临床试验,杂志文章
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abstract::Ultrasound (US) imaging is one of the most popular techniques used in clinical diagnosis, mainly due to lack of adverse effects on patients and the simplicity of US equipment. However, the characteristics of the medium cause US imaging to imprecisely reconstruct examined tissues. The artifacts are the results of wave ...
journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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journal_title:Computer methods and programs in biomedicine
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