Simulation study of PET detector configuration with thick light guide and GAPD array having large-area microcells for high effective quantum efficiency.

Abstract:

BACKGROUND AND OBJECTIVES:Light sharing PET detector configuration coupled with thick light guide and Geiger-mode avalanche photodiode (GAPD) with large-area microcells was proposed to overcome the energy non-linearity problem and to obtain high light collection efficiency (LCE). METHODS:A Monte-Carlo simulation was conducted for the three types of LSO block, 4 × 4 array of 3 × 3 × 20 mm(3) discrete crystals, 6 × 6 array of 2 × 2 × 20 mm(3) discrete crystals, and 12 × 12 array of 1 × 1 × 20 mm(3) discrete crystals, to investigate the scintillation light distribution after conversion of the γ-rays in LSO. The incident photons were read out by three types of 4 × 4 array photosensors, which were PSPMT of 25% quantum efficiency (QE), GAPD1 with 50 × 50 µm(2) microcells of 30% photon detection efficiency (PDE) and GAPD2 with 100 × 100 µm(2) of 45% PDE. The number of counted photons in each photosensor was analytically calculated. The LCE, linearity and flood histogram were examined for each PET detector module having 99 different configurations as a function of light guide thickness ranging from 0 to 10 mm. RESULTS:The performance of PET detector modules based on GAPDs was considerably improved by using the thick light guide. The LCE was increased from 24 to 30% and from 14 to 41%, and the linearity was also improved from 0.97 to 0.99 and from 0.75 to 0.99, for GAPD1 and GAPD2, respectively. As expected, the performance of PSPMT based detector did not change. The flood histogram of 12 × 12 array PET detector modules using 3 mm light guide coupled with GAPDs was obtained by simulation, and all crystals of 1 × 1 × 20 mm(3) size were clearly identified. PET detector module coupled with thick light guide and GAPD array with large-area microcells was proposed to obtain high QE and high spatial resolution, and its feasibility was verified. CONCLUSIONS:This study demonstrated that the overall PET performance of the proposed design was considerably improved, and this approach will provide opportunities to develop GAPD based PET detector with a high LCE.

authors

Kang J,Choi Y

doi

10.1016/j.cmpb.2016.04.007

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

79-87

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(15)30169-3

journal_volume

131

pub_type

杂志文章
  • Prediction of hemodynamic changes towards PEEP titrations at different volemic levels using a minimal cardiovascular model.

    abstract::A cardiovascular system model and parameter identification method have previously been validated for porcine experiments of induced pulmonary embolism and positive end-expiratory pressure (PEEP) titrations, accurately tracking all the main hemodynamic trends. In this research, the model and parameter identification pr...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2008.03.004

    authors: Starfinger C,Chase JG,Hann CE,Shaw GM,Lambert P,Smith BW,Sloth E,Larsson A,Andreassen S,Rees S

    更新日期:2008-08-01 00:00:00

  • An iterative phase correction program for nuclear magnetic resonance (NMR) spectra.

    abstract::An iterative algorithm is given to correct for the zeroth and first order phase errors in NMR spectroscopy. A FORTRAN computer program is listed and two sample runs exemplified. No a priori knowledge of the existing phase errors is required. The parameters are optimised iteratively under the assumption that when the s...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(88)90078-8

    authors: Chen CN,Kan LS

    更新日期:1988-01-01 00:00:00

  • PSO-FCM based data mining model to predict diabetic disease.

    abstract:BACKGROUND AND OBJECTIVE:Diabetic disease is typically composed because of higher than normal blood sugar levels. Instead the production of insulin may be regarded insufficient. It has been noted in recent days that the percentage of diabetes-affected patients have grown to a larger extent throughout the world. Evident...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2020.105659

    authors: Raja JB,Pandian SC

    更新日期:2020-11-01 00:00:00

  • Hospital-wide PACS with a digital image intensifier TV system.

    abstract::Tokyo Hitachi Hospital, Hitachi Ltd., has used a hospital-wide PACS for over 1 year. The system runs a 100 Mb/s optical fiber network over the whole hospital including wards and outpatient clinic rooms, with 11 image workstations. The network links digital imaging modalities such as X-CT, MRI, computed radiography (CR...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(94)90190-2

    authors: Okaniwa H,Tsuneyoshi H,Kabata S,Satoh K,Yokouchi H,Okabe T

    更新日期:1994-05-01 00:00:00

  • Capturing the semantic relationship between clinical terms with current MeSH bibliographic coding.

    abstract::This paper compares bibliographic retrieval using current MeSH (Medical Subject Headings) to bibliographic retrieval using explicitly coded semantic relationships between index terms. In a previous study, ten lists of abstracts, each list containing 20-40 papers discussing a specific pair of terms, were analyzed to id...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(88)90084-3

    authors: Miller PL,Smith P,Morrow JS,Riely CA,Powsner SM

    更新日期:1988-11-01 00:00:00

  • MARVIN: a medical research application framework based on open source software.

    abstract::This paper describes the open source framework MARVIN for rapid application development in the field of biomedical and clinical research. MARVIN applications consist of modules that can be plugged together in order to provide the functionality required for a specific experimental scenario. Application modules work on ...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2008.04.007

    authors: Rudolph T,Puls M,Anderegg C,Ebert L,Broehan M,Rudin A,Kowal J

    更新日期:2008-08-01 00:00:00

  • Distal tibial tuberosity high tibial osteotomy using an image enhancement technique for orthopedic scans in the treatment of medial compartment knee osteoarthritis.

    abstract:OBJECTIVE:To observe the efficacy of distal tibial tuberosity high tibial osteotomy in treating medial compartment osteoarthritis of the knee. In the experiment, a medical image enhancement algorithm based on shear wave domain improved Gamma correction was implemented to process medical images in order to diagnose pati...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2020.105349

    authors: Tian X,Han C,Wang J,Tan Y,Zhu G,Lei M,Ma S,Hu Y,Li S,Chen H,Huang Y

    更新日期:2020-07-01 00:00:00

  • bpshape wk4: a computer program that implements a physiological model for analyzing the shape of blood pressure waveforms.

    abstract::We describe the theory and computer implementation of a newly-derived mathematical model for analyzing the shape of blood pressure waveforms. Input to the program consists of an ECG signal, plus a single continuous channel of peripheral blood pressure, which is often obtained invasively from an indwelling catheter dur...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(93)90020-l

    authors: Ocasio WC,Rigney DR,Clark KP,Mark RG

    更新日期:1993-04-01 00:00:00

  • An extension to 3D topological thinning method based on LUT for colon centerline extraction.

    abstract::Topological thinning is a valid but time-consuming method to calculate the centerline of human colon or other hollow organs accurately. An optimized 3D topological thinning method based on Look-up Table (LUT), which was proposed by Sadlier, proves to be effective in improving the efficiency on many occasions. However,...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2008.10.002

    authors: Ding M,Tong R,Liao SH,Dong J

    更新日期:2009-04-01 00:00:00

  • The moment segmentation analysis of heart sound pattern.

    abstract:UNLABELLED:This paper presents two new ideas. The first one is to apply the Viola integral waveform method to analyze the heart sounds recorded by an electric stethoscope, and the multi-scale moment analysis is proposed to locate each cycle of heart sounds. A fast algorithm for calculating characteristic waveform (CW) ...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2009.09.008

    authors: Yan Z,Jiang Z,Miyamoto A,Wei Y

    更新日期:2010-05-01 00:00:00

  • Mixed convection peristaltic motion of copper-water nanomaterial with velocity slip effects in a curved channel.

    abstract:BACKGROUND AND OBJECTIVE:The primary objective of present analysis is to model the peristalsis of copper-water based nanoliquid in the presence of first order velocity and thermal slip conditions in a curved channel. Mixed convection, viscous dissipation and heat generation/absorption are also accounted. METHOD:Mathem...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2017.02.006

    authors: Hayat T,Farooq S,Alsaedi A

    更新日期:2017-04-01 00:00:00

  • Hash function performance on different biological databases.

    abstract::Open hashing is used to demonstrate the effectiveness of several hashing functions for the uniform distribution of biological records. The three types of database tested include (1) genetic nomenclature, mutation sites and strain names, (2) surnames extracted from literature files and (3) a set of 1000 numeric ASCII s...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(89)90164-8

    authors: Breen EJ,Williams KL

    更新日期:1989-02-01 00:00:00

  • An improved sex-specific and age-dependent classification model for Parkinson's diagnosis using handwriting measurement.

    abstract:BACKGROUND AND OBJECTIVES:Diagnosis of Parkinson's with higher accuracy is always desirable to slow down the progression of the disease and improved quality of life. There are evidences of inherent neurological differences between male and females as well as between elderly and adults. However, the potential of such ge...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2019.105305

    authors: Gupta U,Bansal H,Joshi D

    更新日期:2020-06-01 00:00:00

  • OLYMPUS: an automated hybrid clustering method in time series gene expression. Case study: host response after Influenza A (H1N1) infection.

    abstract::The increasing flow of short time series microarray experiments for the study of dynamic cellular processes poses the need for efficient clustering tools. These tools must deal with three primary issues: first, to consider the multi-functionality of genes; second, to evaluate the similarity of the relative change of a...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2013.05.025

    authors: Dimitrakopoulou K,Vrahatis AG,Wilk E,Tsakalidis AK,Bezerianos A

    更新日期:2013-09-01 00:00:00

  • Optimal dynamic empirical therapy in a health care facility: A Monte-Carlo look-ahead method.

    abstract:BACKGROUND AND OBJECTIVES:Empirical antimicrobial prescription strategies have been proposed to counteract the selection of resistant pathogenic strains. The respective merits of such strategies have been debated. Rather than comparing a finite number of policies, we take an optimization approach and propose a solution...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2020.105767

    authors: Houy N,Flaig J

    更新日期:2021-01-01 00:00:00

  • An optimal code for patient identifiers.

    abstract::How to distinguish 1 billion individuals by an identifier consisting of eight characters, allowing a reasonable amount of error detection or even error correction? Our solution of this problem is an optimal code over a 32-character alphabet that detects up to two errors and corrects one error as well as a transpositio...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2005.03.004

    authors: Faldum A,Pommerening K

    更新日期:2005-07-01 00:00:00

  • Non-invasive assessment of liver quality in transplantation based on thermal imaging analysis.

    abstract:BACKGROUND AND OBJECTIVE:Liver quality evaluation is one of the vital steps for predicting the success of liver transplantation. Current evaluation methods, such as biopsy and visual inspection, which are either invasive or lack of consistent standards, provide limited predictive value of long-term transplant viability...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2018.06.003

    authors: Lan Q,Sun H,Robertson J,Deng X,Jin R

    更新日期:2018-10-01 00:00:00

  • Advanced multimodal visualisation of clinical gait and fluoroscopy analyses in the assessment of total knee replacement.

    abstract::Traditional gait and fluoroscopy analysis of human movement are largely utilised but are still limited in registration, integration, synchronisation and visualisation capabilities. The present work exploits the features of a recently developed software tool based on multimodal display (Data Manager developed within th...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2005.04.007

    authors: Leardini A,Astolfi L,Fantozzi S,Viceconti M,Benedetti MG,Catani F

    更新日期:2005-09-01 00:00:00

  • Measurement systems calibration: microcomputer implementation.

    abstract::Measurement systems used in the collection and processing of laboratory data must be calibrated periodically to obtain accurate results. Because calibration factors can change over time or may be reset to optimize measurements for specific tests, care must be taken to assure that calibration factors and data are align...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(91)90014-k

    authors: Reinking RM,Laouris Y,Stuart DG

    更新日期:1991-09-01 00:00:00

  • The monitoring and managing application of cloud computing based on Internet of Things.

    abstract::Cloud computing and the Internet of Things are the two hot points in the Internet application field. The application of the two new technologies is in hot discussion and research, but quite less on the field of medical monitoring and managing application. Thus, in this paper, we study and analyze the application of cl...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2016.03.024

    authors: Luo S,Ren B

    更新日期:2016-07-01 00:00:00

  • Improving brain tumor characterization on MRI by probabilistic neural networks and non-linear transformation of textural features.

    abstract::The aim of the present study was to design, implement and evaluate a software system for discriminating between metastatic and primary brain tumors (gliomas and meningiomas) on MRI, employing textural features from routinely taken T1 post-contrast images. The proposed classifier is a modified probabilistic neural netw...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2007.10.007

    authors: Georgiadis P,Cavouras D,Kalatzis I,Daskalakis A,Kagadis GC,Sifaki K,Malamas M,Nikiforidis G,Solomou E

    更新日期:2008-01-01 00:00:00

  • frailtypack: a computer program for the analysis of correlated failure time data using penalized likelihood estimation.

    abstract::Correlated survival outcomes occur quite frequently in the biomedical research. Available software is limited, particularly if we wish to obtain smoothed estimate of the baseline hazard function in the context of random effects model for correlated data. The main objective of this paper is to describe an R package cal...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2005.06.010

    authors: Rondeau V,Gonzalez JR

    更新日期:2005-11-01 00:00:00

  • Unique identification code for medical fundus images using blood vessel pattern for tele-ophthalmology applications.

    abstract:BACKGROUND AND OBJECTIVE:Identification of fundus images during transmission and storage in database for tele-ophthalmology applications is an important issue in modern era. The proposed work presents a novel accurate method for generation of unique identification code for identification of fundus images for tele-ophth...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2016.07.011

    authors: Singh A,Dutta MK,Sharma DK

    更新日期:2016-10-01 00:00:00

  • Construction of the flow rate nomogram using polynomial regression.

    abstract::The urinary flow rates of normal individuals depend on the initial bladder volume in a non-linear fashion (J. Urol. 109 (1973) 874). A flow rate nomogram was developed by Siroky, Olsson and Krane, (J. Vol. 122 (1979) 665), taking the non-linear relationship into account, as an aid in the interpretation of urinary flow...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(93)90030-o

    authors: Hosmane B,Maurath C,McConnell M

    更新日期:1993-04-01 00:00:00

  • Computerised algorithm of tumour-associated markers to monitor haematopoietic malignancy.

    abstract::Hexosaminidase, polyamines and lipid-bound sialic acid are a few tumour-associated markers which are significantly elevated both in urine and serum of patients with haematopoietic malignancy, in direct correlation to dedifferentiation. Our computer database incorporates these parameters and predicts the clinical respo...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(90)90032-5

    authors: Venkatanarayanan S,Nagarajan B

    更新日期:1990-01-01 00:00:00

  • Towards noise immune detection of fetal QRS complexes.

    abstract::The noninvasive fetal electrocardiography is a source of more precise information on the fetal heart activity than the measurements based on Doppler ultrasound signals. However, the clinical diagnostic applications of this technique are limited by difficulty with successful detection of small amplitude fetal QRS compl...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2009.09.005

    authors: Kotas M,Jezewski J,Matonia A,Kupka T

    更新日期:2010-03-01 00:00:00

  • MODDIS: a microcomputer program for model discrimination.

    abstract::A computer program for a microcomputer (HP 86) is presented to discriminate between different models and to design new experiments for model discrimination. By a non-linear fitting algorithm a set of experimental data is fitted with different models suggested by the user. The parameters characterizing each model are e...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(86)90022-2

    authors: Verotta D,Recchia M,Urso R

    更新日期:1986-04-01 00:00:00

  • Cross-sectional photoacoustic tomography image reconstruction with a multi-curve integration model.

    abstract:BACKGROUND AND OBJECTIVE:In acoustic inversion of photoacoustic tomography (PAT), an imaging model that precisely describes both the ultrasonic wave propagation and the detector properties is of crucial importance. Inspired by the multi-stripe integration model in clinical X-ray computed tomography systems, in this wor...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2020.105731

    authors: Qi L,Huang S,Li X,Zhang S,Lu L,Feng Q,Chen W

    更新日期:2020-12-01 00:00:00

  • Epileptic EEG detection using neural networks and post-classification.

    abstract::Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/j.cmpb.2008.02.005

    authors: Patnaik LM,Manyam OK

    更新日期:2008-08-01 00:00:00

  • BB_RADABA: a computer program as a tool for breeding and management of laboratory animals.

    abstract::The use of well characterized laboratory animals in biomedical research is of importance for quality securing and reproducibility of animal experiments. Therefore, breeders should not only have in mind the reproduction of their animal stocks, but they should also be interested to achieve an optimal resemblance of the ...

    journal_title:Computer methods and programs in biomedicine

    pub_type: 杂志文章

    doi:10.1016/0169-2607(92)90076-j

    authors: Vogt L,Klöting I

    更新日期:1992-06-01 00:00:00