Abstract：
:A cardiovascular system model and parameter identification method have previously been validated for porcine experiments of induced pulmonary embolism and positive end-expiratory pressure (PEEP) titrations, accurately tracking all the main hemodynamic trends. In this research, the model and parameter identification process are further validated by predicting the effect of intervention. An overall population-specific rule linking specific model parameters to increases in PEEP is formulated to predict the hemodynamic effects on arterial pressure, pulmonary artery pressure and stroke volume. Hemodynamic changes are predicted for an increase from 0 to 10 cm H(2)O with median absolute percentage errors less than 7% (systolic pressures) and 13% (stroke volume). For an increase from 10 to 20 cm H(2)O median absolute percentage errors are less than 11% (systolic pressures) and 17% (stroke volume). These results validate the general applicability of such a rule, which is not pig-specific, but holds over for all analyzed pigs. This rule enables physiological simulation and prediction of patient response. Overall, the prediction accuracy achieved represents a further clinical validation of these models, methods and overall approach to cardiovascular diagnosis and therapy guidance.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Starfinger C,Chase JG,Hann CE,Shaw GM,Lambert P,Smith BW,Sloth E,Larsson A,Andreassen S,Rees Sdoi
10.1016/j.cmpb.2008.03.004subject
Has Abstractpub_date
2008-08-01 00:00:00pages
128-34issue
2eissn
0169-2607issn
1872-7565pii
S0169-2607(08)00078-3journal_volume
91pub_type
杂志文章abstract：:Tools for calculating Gaussian parametric statistics are widely available in hand-held calculators and program packages for desktop as well as mainframe computers. The standard deviation calculated from non-Gaussian data may, however, be meaningless or even absurd. Furthermore, the standard error of the mean is freque...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90046-6
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Drug-target interaction prediction plays an intrinsic role in the drug discovery process. Prediction of novel drugs and targets helps in identifying optimal drug therapies for various stringent diseases. Computational prediction of drug-target interactions can help to identify potential drug-ta...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.08.011
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The aim of this articles is to investigate the entropy optimization in Darcy-Forchheimer hybrid nanofluids flow towards a stretchable surface. The flow is caused due to stretching of surface. Energy equation is discussed through heat generation/absorption, viscous dissipation and heat flux. Here molybdenum d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105152
更新日期：2020-03-01 00:00:00
abstract：:This paper describes the use and potential use of mathematical modelling, computer simulation, real-time parameter identification and adaptive feedback control techniques in data-rich clinical environments. We consider a system to be operating in a data-rich environment when measurements of system inputs and outputs a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(87)90049-6
更新日期：1987-09-01 00:00:00
abstract：:The concept of object-oriented design and programming has recently received a great deal of attention from the software engineering community. This paper highlights the realisable benefits of using the object-oriented approach in the design and development of clinical decision support systems. These systems seek to bu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90093-9
更新日期：1991-12-01 00:00:00
abstract：:Glucose-insulin system models are commonly used for identifying insulin sensitivity. With physiological, 2-compartment insulin kinetics models, accurate kinetic parameter values are required for reliable estimates of insulin sensitivity. This study uses data from 6 published microdialysis studies to determine the most...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2014.01.011
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:3D freehand Ultrasonography is a medical imaging technique that can be used to measure muscle and tendon morphological and structural properties, including volume, lengths and echo-intensity. These properties are clinically relevant in neurological disorders such as spastic cerebral palsy to mo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.12.023
更新日期：2018-03-01 00:00:00
abstract：:Guyton's original integrative physiology model was a milestone in integrative physiology, combining significant physiological knowledge with an engineering perspective to develop a computational diagrammatic model. It is still used in research and teaching, with a small number of variants on the model also in circulat...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.05.001
更新日期：2011-06-01 00:00:00
abstract：:Cosmetic doctor utilizes the position, size and shapes of female's breast to judge whether the breast is under steady-state condition after breast implant plastic surgery. Since, doctor evaluates the breast condition with the subjective discrimination (such as vision, sense of touch) without using the objective physic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.11.013
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:The purpose of the study was to probe into the changes in life expectancy associated with schooling years found by the Organization for Economic Co-operation and Development (OECD). METHODS:The study was based on the OECD database from the period 2000 to 2006. The data of thirty countries were constructed t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.11.016
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Empirical antimicrobial prescription strategies have been proposed to counteract the selection of resistant pathogenic strains. The respective merits of such strategies have been debated. Rather than comparing a finite number of policies, we take an optimization approach and propose a solution...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105767
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:Efficient clinical treatment processes is considered a key factor of medical quality control. Current IT solutions are far away from this perspective since they typically have difficulty supporting the variances occurring in clinical practices, and providing adequate flexible support of clinical processes. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.12.005
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:This study was performed to evaluate the usefulness of virtual magnetic resonance microscopy (VMRM) for the diagnosis of cerebral aneurysms. MATERIALS AND METHODS:We reviewed 11 patients with unruptured aneurysms confirmed by angiography or surgical therapy. We evaluated the ability of VMRM to represent aneury...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00142-0
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In oral and maxillofacial surgery, conventional radiographic cephalometry is one of the standard auxiliary tools for diagnosis and surgical planning. While contemporary computer-assisted cephalometric systems and methodologies support cephalometric analysis, they tend neither to be practical no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.014
更新日期：2016-07-01 00:00:00
abstract：:The identification of thousands of mutations yearly has put new challenges to researchers who are interested in fast and effective annotation as well as the prediction of potential implications to the gene regulation mechanisms. This work presents an integrative tool, called GREMET, for the prediction of alterations i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:Multicenter clinical trials usually involve several hundred research variables with tens of thousands of records and require mainframe computers for processing. Because of recent advances in hardware and software, it has become possible to support data management and statistical analysis for a complex research project...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90094-1
更新日期：1989-12-01 00:00:00
abstract：:How to distinguish 1 billion individuals by an identifier consisting of eight characters, allowing a reasonable amount of error detection or even error correction? Our solution of this problem is an optimal code over a 32-character alphabet that detects up to two errors and corrects one error as well as a transpositio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.004
更新日期：2005-07-01 00:00:00
abstract：:Epilepsy Expert is a decision support system based on the International Classification of Epilepsies and Epileptic Syndromes (1989). The aim of this study was to evaluate the Epilepsy Expert. First the diagnostic performance was validated. This was done in 3 stages: collection of the patient cases, determination of th...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90206-2
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Diagnosis of Parkinson's with higher accuracy is always desirable to slow down the progression of the disease and improved quality of life. There are evidences of inherent neurological differences between male and females as well as between elderly and adults. However, the potential of such ge...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105305
更新日期：2020-06-01 00:00:00
abstract：:Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.02.005
更新日期：2008-08-01 00:00:00
abstract：:A discrete model has been developed which reproduces the intercellular electrophysiological processes within a block of myocardial tissue. The behaviour of individual elements is introduced in the form of the digitised physiologic and premature action potentials which are comprehended as series of jumps between discre...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90070-a
更新日期：1991-06-01 00:00:00
abstract：:The importance of computer aided decision making is continuously increasing. In the ICU, medical decision support services gather and process medical data of patients and present results and suggestions to the medical staff. The medical decision support services can monitor for example blood pressure, creatinine level...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.05.003
更新日期：2008-09-01 00:00:00
abstract：:Advances in the area of computerized image analysis applied to mammography may have very important practical applications in automatically detecting asymmetries (masses, architectural distortions, etc.) between the two breasts. We have developed a fully automatic technique to detect the breast border and the nipple, t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(96)01724-5
更新日期：1996-05-01 00:00:00
abstract：:We have developed a fast, user friendly, ray-tracing program, "CSIM" for low-energy gamma rays (up to ∼200keV) to simulate the performance characteristics of parallelhole collimators. We have used a ray-tracing approach to find the sensitivity and resolution of the parallelhole collimator by including the penetration ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.12.004
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In this note we propose a nonlinear programming approach for simultaneous fitting of quantile regression models for two or more quantiles. The approach is straightforward, flexible and practical. We apply this approach to a dataset of lactic acid values from a screening dataset in childhood mal...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.10.019
更新日期：2018-01-01 00:00:00
abstract：:In the case of an unexpected high frequency of serious adverse events (SAE), statistical methods are needed to help in the decision making process as to continuation of accrual to the trial. This paper describes an R package, named SAE that implements a method recently developed by defining stopping rules after each o...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.05.005
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study was to provide numerical evidence that latanoprost induced iris darkening (LIID) can be caused by changes to the melanin granule size distribution in the anterior segment of the iris. Iridectomies from two patients were used, where both had undergone unilateral treatment with latanoprost and had ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.04.010
更新日期：2007-08-01 00:00:00
abstract：:We have developed a new system to produce target movements for our particular purposes using a microcomputer and 9-bit digital-to-analog converter. A continuously changing sinusoidal wave was produced to examine the relationship between the frequencies of target movements and smooth pursuit. A random sinusoidal wave w...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90057-x
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The purpose of this study is to examine the reliability of the clinical use of the self-built decision support system, diagnosis-supported attention deficit hyperactivity disorder (DS-ADHD), in an effort to develop the DS-ADHD system, by probing into the development of indicating patterns of p...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.12.003
更新日期：2017-03-01 00:00:00
abstract：:We designed and implemented algorithms for three-dimensional (3-D) reconstruction of brain images from serial sections using two important supercomputer architectures, vector and parallel. These architectures were represented by the Cray YMP and Connection Machine CM-2, respectively. The programs operated on linear oc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(95)01619-5
更新日期：1995-02-01 00:00:00
