Abstract:
:This paper describes the use and potential use of mathematical modelling, computer simulation, real-time parameter identification and adaptive feedback control techniques in data-rich clinical environments. We consider a system to be operating in a data-rich environment when measurements of system inputs and outputs are frequently available. Two particular application examples which illustrate the power of these techniques will be examined. The first example that will be described involves the development and testing of a real-time adaptive controller for simultaneous regulation of mean arterial pressure and cardiac output using two drugs. The second application of these techniques involves the real-time control of electrical stimulation for the functional use of paralyzed muscles in neuroprosthetic devices.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Chizeck HJdoi
10.1016/0169-2607(87)90049-6subject
Has Abstractpub_date
1987-09-01 00:00:00pages
135-40issue
2eissn
0169-2607issn
1872-7565pii
0169-2607(87)90049-6journal_volume
25pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:Dataset imbalance is an important problem in neuroimaging. Imbalanced datasets would cause the performance degradation of a classifier by utilizing imbalanced learning, which tends to overfocus on the majority class. In this paper, we consider an imbalanced neuroimaging classification problem, ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105676
更新日期:2020-11-01 00:00:00
abstract::We have developed a fast, user friendly, ray-tracing program, "CSIM" for low-energy gamma rays (up to ∼200keV) to simulate the performance characteristics of parallelhole collimators. We have used a ray-tracing approach to find the sensitivity and resolution of the parallelhole collimator by including the penetration ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2012.12.004
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abstract:BACKGROUND AND OBJECTIVE:Hepatocellular ballooning is an important histological parameter in the diagnosis of nonalcoholic steatohepatitis (NASH), and it is considered to be a morphological pattern that indicates the severity and the progression to cirrhosis and liver-related deaths. There remains uncertainty about the...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105614
更新日期:2020-10-01 00:00:00
abstract::Selecting appropriate ventilator settings decreases the risk of ventilator-induced lung injury. A decision support system (DSS) has been developed based on physiological models, which can advise on setting of tidal volume (Vt), respiratory frequency (f) and fraction of inspired oxygen (FiO2). The aim of this study is ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2008.07.001
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Finite element based simulation has emerged as a powerful tool to analyse the tooth strength and its fracture characteristics. The aim of this study is to compare and evaluate the fracture resistance of immature teeth reinforcement with MTA, Biodentine and Bioaggregate as an apical plug and bac...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105356
更新日期:2020-07-01 00:00:00
abstract::Hexosaminidase, polyamines and lipid-bound sialic acid are a few tumour-associated markers which are significantly elevated both in urine and serum of patients with haematopoietic malignancy, in direct correlation to dedifferentiation. Our computer database incorporates these parameters and predicts the clinical respo...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(90)90032-5
更新日期:1990-01-01 00:00:00
abstract::The paper presents a computer-based assessment for facioscapulohumeral dystrophy (FSHD) diagnosis through characterisation of the fat and oedema percentages in the muscle region. A novel multi-slice method for the muscle-region segmentation in the T1-weighted magnetic resonance images is proposed using principles of t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2015.03.006
更新日期:2015-06-01 00:00:00
abstract::DIMSUM, an acronym for DIMension of a SUM of exponentials, is a highly automated expert system for fitting multiexponential models of increasing dimension to time series data. Up to now, a researcher has needed an individual copy of DIMSUM on his or her own computer as well as support to learn how to use it. W3DIMSUM,...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2005.03.008
更新日期:2005-08-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.06.002
更新日期:2019-09-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.04.005
更新日期:2017-07-01 00:00:00
abstract::Analysis of multichannel ECG recordings (body surface maps (BSMs) and intracardial maps) requires special software. We created a software package and a user interface on top of a commercial data analysis package (MATLAB) by a combination of high-level and low-level programming. Our software was created to satisfy the ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(02)00014-7
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Low-dose X-ray fluoroscopy has continually evolved to reduce radiation risk to patients during clinical diagnosis and surgery. However, the reduction in dose exposure causes quality degradation of the acquired images. In general, an X-ray device has a time-average pre-processor to remove the ge...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.09.010
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Stable isotope labeling by amino acids in cell culture (SILAC) is a practical and powerful approach for quantitative proteomic analysis. A key advantage of SILAC is the ability to simultaneously detect the isotopically labeled peptides in a single instrument run and so guarantee relative quanti...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.09.017
更新日期:2016-12-01 00:00:00
abstract::A method to determine the shapes of a thermally fluctuating phospholipid vesicle is described. The vesicle that was attached at one point to a glass plate was submitted to a flow. It was observed by an inverted optical microscope using phase contrast technique. A large number of consecutive video images were digitised...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/S0169-2607(03)00065-8
更新日期:2004-03-01 00:00:00
abstract::Arterial bypass grafts tend to fail after some years due to the development of intimal thickening (restenosis). Non-uniform hemodynamics following a bypass operation contributes to restenosis and bypass failure can occur due to the focal development of anastomotic intimal hyperplasia. Additionally, surgical injury agg...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章,评审
doi:10.1016/j.cmpb.2011.12.005
更新日期:2012-11-01 00:00:00
abstract::For the first time compressed sampling (CS) has been applied to heart rate (HR) measurements. The signals can be reconstructed from samples far below the Nyquist rate with negligible small errors, a sampling reduction of 8 has been demonstrated in the paper. As a result, the bitrate of the CS sampler is half when comp...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2012.06.002
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hypokinetic dysarthria (HD) is a frequent speech disorder associated with idiopathic Parkinson's disease (PD). It affects all dimensions of speech production. One of the most common features of HD is dysprosody that is characterized by alterations of rhythm and speech rate, flat speech melody, ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2015.12.011
更新日期:2016-04-01 00:00:00
abstract::Cone beam computed tomography (CBCT) enables volumetric image reconstruction from 2D projection data and plays an important role in image guided radiation therapy (IGRT). Filtered back projection is still the most frequently used algorithm in applications. The algorithm discretizes the scanning process (forward projec...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2011.12.002
更新日期:2012-11-01 00:00:00
abstract::Quesenberry and Hurst (1964), Goodman (1965) and Fitzpatrick and Scott (1987) proposed simultaneous construction of confidence intervals for multinomial proportions, however. statistical computing packages do not generally give one the option of specifying the type of construction to be used. We have written a SAS mac...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(97)01809-9
更新日期:1997-07-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105914
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND AND OBJECTIVE:A new expert system is proposed to discriminate healthy people from people with Parkinson's Disease (PD) in early stages by using Diadochokinesis tests. METHODS:The system is based on temporal and spectral features extracted from the Voice Onset Time (VOT) segments of /ka/ syllables, whose bou...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.11.010
更新日期:2018-02-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::A new iterative polyexponential curve stripping technique for the provision of initial pharmacokinetic parameter estimates has been developed. Such estimates are required for nonlinear least-squares curve fitting. In contrast to conventional curve stripping, this new technique does not make any assumption about the re...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(85)90085-9
更新日期:1985-08-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(93)90020-l
更新日期:1993-04-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2018.04.022
更新日期:2018-07-01 00:00:00
abstract::An outline of the Hokkaido University PACS (HU-PACS) and 10 months experience of its clinical use are reported. It is concluded that HU-PACS is a useful clinical tool, even though some points still remain to be improved. ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(91)90049-y
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Diagnosis of Parkinson's with higher accuracy is always desirable to slow down the progression of the disease and improved quality of life. There are evidences of inherent neurological differences between male and females as well as between elderly and adults. However, the potential of such ge...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105305
更新日期:2020-06-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(89)90069-2
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Magnetic resonance (MR) imaging is increasingly used in studies of speech as it enables non-invasive visualisation of the vocal tract and articulators, thus providing information about their shape, size, motion and position. Extraction of this information for quantitative analysis is achieved u...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105814
更新日期:2021-01-01 00:00:00
abstract::This work provides a performance comparison of four different machine learning classifiers: multinomial logistic regression with ridge estimators (MLR) classifier, k-nearest neighbours (KNN), support vector machine (SVM) and naïve Bayes (NB) as applied to terahertz (THz) transient time domain sequences associated with...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.01.017
更新日期:2016-04-01 00:00:00