Abstract:
BACKGROUND AND OBJECTIVE:T-wave alternans (TWA) is a fluctuation of the ST-T complex occurring on an every-other-beat basis of the surface electrocardiogram (ECG). It has been shown to be an informative risk stratifier for sudden cardiac death, though the lack of gold standard to benchmark detection methods has promoted the use of synthetic signals. This work proposes a novel signal model to study the performance of a TWA detection. Additionally, the methodological validation of a denoising technique based on empirical mode decomposition (EMD), which is used here along with the spectral method, is also tackled. METHODS:The proposed test bed system is based on the following guidelines: (1) use of open source databases to enable experimental replication; (2) use of real ECG signals and physiological noise; (3) inclusion of randomized TWA episodes. Both sensitivity (Se) and specificity (Sp) are separately analyzed. Also a nonparametric hypothesis test, based on Bootstrap resampling, is used to determine whether the presence of the EMD block actually improves the performance. RESULTS:The results show an outstanding specificity when the EMD block is used, even in very noisy conditions (0.96 compared to 0.72 for SNR = 8 dB), being always superior than that of the conventional SM alone. Regarding the sensitivity, using the EMD method also outperforms in noisy conditions (0.57 compared to 0.46 for SNR=8 dB), while it decreases in noiseless conditions. CONCLUSIONS:The proposed test setting designed to analyze the performance guarantees that the actual physiological variability of the cardiac system is reproduced. The use of the EMD-based block in noisy environment enables the identification of most patients with fatal arrhythmias.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Blanco-Velasco M,Goya-Esteban R,Cruz-Roldán F,García-Alberola A,Rojo-Álvarez JLdoi
10.1016/j.cmpb.2017.04.005subject
Has Abstractpub_date
2017-07-01 00:00:00pages
147-155eissn
0169-2607issn
1872-7565pii
S0169-2607(16)30528-4journal_volume
145pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:3D freehand Ultrasonography is a medical imaging technique that can be used to measure muscle and tendon morphological and structural properties, including volume, lengths and echo-intensity. These properties are clinically relevant in neurological disorders such as spastic cerebral palsy to mo...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.12.023
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In the last decade, RNA-sequencing technology has become method-of-choice and prefered to microarray technology for gene expression based classification and differential expression analysis since it produces less noisy data. Although there are many algorithms proposed for microarray data, the n...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.04.007
更新日期:2019-07-01 00:00:00
abstract::Image analysis is a rapidly evolving field with growing applications in science and engineering. In cancer research, it has played a key role in advancing techniques of major diagnostic importance, minimising human intervention and providing vital clinical information. Especially in the field of tissue microscopy, the...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2003.07.001
更新日期:2004-06-01 00:00:00
abstract::As we continue to strive to apply the findings of in vitro and animal studies to human disease and transition from genomics to proteomics, we will experience an ever-increasing need for human tissues. A web based system that provides access to tissues repositories and associated data will best facilitate the access to...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章,评审
doi:10.1016/s0169-2607(02)00002-0
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:False positive alerts in patient-safety-related clinical decision support systems (CDSS) are defined as alerts which incorrectly prompt when no-risk patients are encountered. It is an unfavorable condition which may potentially mislead physicians. The aim is to investigate physician responses toward false po...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cmpb.2016.04.011
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Study of nanofluids has been enormously increased for the last couple of years. Regardless of some irregularity in the revealed outcomes and lacking consistency, yet the mechanisms of heat transport have been emerged as highly efficient. In the continuation of nanomaterials research, the investigators and an...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105093
更新日期:2020-01-01 00:00:00
abstract::The microcomputer program presented here allows the simulation of linear compartmental physiological models whose structure is known. The method used is the 4th order Runge-Kutta method. Implemented on the Apple IIe, this program is fully interactive and presents the possibility of changing model parameters or initial...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(87)90066-6
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:To observe the efficacy of distal tibial tuberosity high tibial osteotomy in treating medial compartment osteoarthritis of the knee. In the experiment, a medical image enhancement algorithm based on shear wave domain improved Gamma correction was implemented to process medical images in order to diagnose pati...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105349
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The large intra-patient variability in type 1 diabetic patients dramatically reduces the ability to achieve adequate blood glucose control. A novel methodology to identify different blood glucose dynamics profiles will allow therapies to be more accurate and tailored according to patient's conditions and to ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.08.022
更新日期:2016-11-01 00:00:00
abstract::As many structures of protein-DNA complexes have been known in the past years, several computational methods have been developed to predict DNA-binding sites in proteins. However, its inverse problem (i.e., predicting protein-binding sites in DNA) has received much less attention. One of the reasons is that the differ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2014.07.009
更新日期:2014-11-01 00:00:00
abstract::The popularity of the use of Apple II/IIe hardware in medical applications is evidenced by the variety of articles devoted to the use of this hardware in biomedical research and medical practice. Many of these applications are of a stochastic nature, including simulations, and depend on the Applesoft random number gen...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(88)90002-8
更新日期:1988-05-01 00:00:00
abstract::This paper summarizes the main topics of discussion at a workshop hosted by the Centre for Law Ethics and Risk in Telemedicine at the 2nd International Conference on Advances in the Delivery of Care, held at the Institute of Health Sciences, City University, London from Wednesday 24 to Friday 26 March 1999. The worksh...
journal_title:Computer methods and programs in biomedicine
pub_type:
doi:10.1016/s0169-2607(00)00142-5
更新日期:2001-03-01 00:00:00
abstract::A confocal microscope can produce gray-scale images of the different layers of the cornea. We have addressed the problem of classifying these images, i.e. recognizing the layer displayed, using the shape of the cells contained, which is uniquely related to each specific layer. A first method was designed, based first ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(01)00153-5
更新日期:2002-04-01 00:00:00
abstract::ENZEDUC 1.0 is a software package developed in Microsoft QuickBASIC v7.1 for computation of hyperbolic enzyme kinetics. The educational focus of the package is laboratory practical teaching. The program can manage a maximum of 18 substrate concentration values and 72 reaction rate values for each substrate concentrati...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(96)01716-6
更新日期:1996-03-01 00:00:00
abstract::A PC-based HIS/RIS/Modality/PACS coupling was developed and operated where hospital-wide PACS was closely cooperated with the HIS and RIS. Three workstations with a magneto-optical disk (MOD) juke-box for each one were used as PACS servers to collect images from eight computed radiography systems and three CT scanners...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(98)00046-7
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Low-dose X-ray fluoroscopy has continually evolved to reduce radiation risk to patients during clinical diagnosis and surgery. However, the reduction in dose exposure causes quality degradation of the acquired images. In general, an X-ray device has a time-average pre-processor to remove the ge...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.09.010
更新日期:2017-12-01 00:00:00
abstract::A simple programme has been written in GW BASIC to calculate the percentage activity of 99Tcm-radiopharmaceuticals in different tissues after biodistribution. The programme is efficient, easy to handle and produces a permanent record in terms of a final report. ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90139-2
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Glaucoma, a worldwide eye disease, may cause irreversible vision damage. If not treated properly at an early stage, glaucoma eventually deteriorates into blindness. Various glaucoma screening methods, e.g. Ultrasound Biomicroscopy (UBM), Optical Coherence Tomography (OCT), and Heidelberg Retina...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105717
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Light sharing PET detector configuration coupled with thick light guide and Geiger-mode avalanche photodiode (GAPD) with large-area microcells was proposed to overcome the energy non-linearity problem and to obtain high light collection efficiency (LCE). METHODS:A Monte-Carlo simulation was c...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.04.007
更新日期:2016-07-01 00:00:00
abstract::A dynamic simulation model for the epithelial cell structures of the intestine has been developed. The model is based on hypotheses found in the literature. It is shown that basic cell dynamics can be reproduced by simulation experiments. The simulation program is designed so that model output comparable with experime...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(85)90067-7
更新日期:1985-11-01 00:00:00
abstract::The aim of DILEMMA is to provide tools for the development of decision support systems for use in general medical practice, hospital-based cancer care, and shared care of cancer and cardiology patients. In primary care, the project intends to provide aids to clinical performance in prescribing, referral and the use of...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90011-6
更新日期:1994-10-01 00:00:00
abstract::A veterinary anatomy tutoring system was developed by using Knowledge Pro, an object-oriented software development tool with hypermedia capabilities, and MS Access, a relational database. Communication between them is facilitated by using the Structured Query Language (SQL). The architecture of the system is based on ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90045-0
更新日期:1994-02-14 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Accurate and fast vessel segmentation from liver slices remain challenging and important tasks for clinicians. The algorithms from the literature are slow and less accurate. We propose fast parallel gradient based seeded region growing for vessel segmentation. Seeded region growing is tedious w...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105430
更新日期:2020-08-01 00:00:00
abstract::Traditional gait and fluoroscopy analysis of human movement are largely utilised but are still limited in registration, integration, synchronisation and visualisation capabilities. The present work exploits the features of a recently developed software tool based on multimodal display (Data Manager developed within th...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2005.04.007
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Standardization of the carotid IMT requires a reference marker in ultrasound scans. It has been shown previously that manual reference marker and manually created carotid segments are used for measuring IMT in these segments. Manual methods are tedious, time consuming, subjective, and prone to...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.01.009
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To ove...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.11.007
更新日期:2018-02-01 00:00:00
abstract::When analysing postural control statistical characteristics of the centre of pressure or the ground reaction force are often used. A complement would be to analyse movement strategies as well. The purpose of this study was to determine to what extent the ankle strategy is used to maintain the balance in standing. One ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(96)01794-4
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Model-based lung mechanics monitoring can provide clinically useful information for guiding mechanical ventilator treatment in intensive care. However, many methods of measuring lung mechanics are not appropriate for both fully and partially sedated patients, and are unable provide lung mechani...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105184
更新日期:2020-04-01 00:00:00
abstract::Cone beam computed tomography (CBCT) enables volumetric image reconstruction from 2D projection data and plays an important role in image guided radiation therapy (IGRT). Filtered back projection is still the most frequently used algorithm in applications. The algorithm discretizes the scanning process (forward projec...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2011.12.002
更新日期:2012-11-01 00:00:00
abstract::Contrast and brightness matching are often required in many medical imaging applications, especially when comparing medical data acquired over different time periods, due to dissimilarities in the acquisition process. Numerous methods have been proposed in this field, ranging from simple correction filters to more com...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2011.03.011
更新日期:2012-06-01 00:00:00