Abstract：
:In the case of an unexpected high frequency of serious adverse events (SAE), statistical methods are needed to help in the decision making process as to continuation of accrual to the trial. This paper describes an R package, named SAE that implements a method recently developed by defining stopping rules after each observed SAE. The package function control for excessive toxicity either during the trial at the observation of each SAE (function SAE) or during the planning phase of a clinical trial (function DESIGN). This description and the package documentation are complementary to help the users to apply the method. The main difficulty in the implementation of the method is the choice of a priori parameters. Data from an ongoing clinical trial are presented as an example to improve the understanding and the use of the package.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Bascoul-Mollevi C,Laplanche A,Le Deley MC,Kramar Adoi
10.1016/j.cmpb.2011.05.005subject
Has Abstractpub_date
2011-11-01 00:00:00pages
243-8issue
2eissn
0169-2607issn
1872-7565pii
S0169-2607(11)00120-9journal_volume
104pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVES:Standardization of the carotid IMT requires a reference marker in ultrasound scans. It has been shown previously that manual reference marker and manually created carotid segments are used for measuring IMT in these segments. Manual methods are tedious, time consuming, subjective, and prone to...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.01.009
更新日期：2017-04-01 00:00:00
abstract：:Radiologic and clinical practice can be enhanced by improved access to multimodal image information. Analysis, visualization, method characteristic image processing and image synthesis is needed not only for the interpretation of the images but also for performing effective consultations with clinical colleagues and c...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90070-1
更新日期：1994-06-01 00:00:00
abstract：:This paper presents an overview of the image analysis techniques in the domain of histopathology, specifically, for the objective of automated carcinoma detection and classification. As in other biomedical imaging areas such as radiology, many computer assisted diagnosis (CAD) systems have been implemented to aid hist...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.12.007
更新日期：2012-09-01 00:00:00
abstract：:This paper describes the open source framework MARVIN for rapid application development in the field of biomedical and clinical research. MARVIN applications consist of modules that can be plugged together in order to provide the functionality required for a specific experimental scenario. Application modules work on ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.04.007
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Drug-target interaction prediction plays an intrinsic role in the drug discovery process. Prediction of novel drugs and targets helps in identifying optimal drug therapies for various stringent diseases. Computational prediction of drug-target interactions can help to identify potential drug-ta...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.08.011
更新日期：2018-10-01 00:00:00
abstract：:Entity-Attribute-Value (EAV) data, as present in repositories of clinical patient data, must be transformed (pivoted) into one-column-per-parameter format before it can be used by a variety of analytical programs. Pivoting approaches have not been described in depth in the literature, and existing descriptions are dat...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.02.001
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Respiratory mechanics estimation can be used to guide mechanical ventilation (MV) but is severely compromised when asynchronous breathing occurs. In addition, asynchrony during MV is often not monitored and little is known about the impact or magnitude of asynchronous breathing towards recovery...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.02.007
更新日期：2018-04-01 00:00:00
abstract：:Tight glycemic control (TGC) has shown benefits in ICU patients, but been difficult to achieve consistently due to inter- and intra- patient variability that requires more adaptive, patient-specific solutions. STAR (Stochastic TARgeted) is a flexible model-based TGC framework accounting for patient variability with a ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.07.003
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Stable isotope labeling by amino acids in cell culture (SILAC) is a practical and powerful approach for quantitative proteomic analysis. A key advantage of SILAC is the ability to simultaneously detect the isotopically labeled peptides in a single instrument run and so guarantee relative quanti...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.09.017
更新日期：2016-12-01 00:00:00
abstract：:Last 10 years have witnessed the growth of many computer applications for the segmentation of the vessel wall in ultrasound imaging. Epidemiological studies showed that the thickness of the major arteries is an early and effective marker of onset of cardiovascular diseases. Ultrasound imaging, being real-time, economi...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2010.04.007
更新日期：2010-12-01 00:00:00
abstract：:Diabetes mellitus (DM) is a metabolic disorder that is widely rampant throughout the world population these days. The uncontrolled DM may lead to complications of eye, heart, kidney and nerves. The most common type of diabetes is the type 2 diabetes or insulin-resistant DM. Near-infrared spectroscopy (NIRS) technology...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.08.018
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:With ongoing interest in CNT nanofluids and materials in biotechnology, energy and environment, microelectronics, composite materials etc., the current investigation is carried out to analyze the effects of variable viscosity and thermal conductivity of CNT nanofluids flow driven by cilia indu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：:This research project sought to design and implement a computerized clinical decision support system (CDSS) that was able to identify patients who were at risk of pulmonary embolism (PE) and deep vein thrombosis (DVT), as well as produce reminders for prophylactic action for these diseases. The main purpose of the CDS...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2014.03.007
更新日期：2014-07-01 00:00:00
abstract：:This corrigendum corrects the dimensions of partial differential equations in the paper [1], where these mistakes are occurred during typing processes. But the results in [1] does not affect the scientific and mathematical validity of the paper. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 信件
doi：10.1016/j.cmpb.2019.105251
更新日期：2020-04-01 00:00:00
abstract：:The identification of thousands of mutations yearly has put new challenges to researchers who are interested in fast and effective annotation as well as the prediction of potential implications to the gene regulation mechanisms. This work presents an integrative tool, called GREMET, for the prediction of alterations i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:Subcutaneous insulin kinetics is a complex process whose quantitation is needed for a reliable glycemic control in the conventional therapy of insulin-dependent diabetes. The major difficulties in modeling include accounting for the distribution in the subcutaneous depot and transport to plasma. A single model describ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/s0169-2607(00)00071-7
更新日期：2000-07-01 00:00:00
abstract：:A confocal microscope can produce gray-scale images of the different layers of the cornea. We have addressed the problem of classifying these images, i.e. recognizing the layer displayed, using the shape of the cells contained, which is uniquely related to each specific layer. A first method was designed, based first ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00153-5
更新日期：2002-04-01 00:00:00
abstract：:A software package for the IBM PC computer is presented to facilitate the analysis of three-channel Lissajous' trajectories (3CLT) of auditory brainstem potentials. The program deals with 4-channel numeric or ASCII files, including three orthogonal X, Y, Z channels and standard vertex-mastoid on the stimulated side. T...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90096-r
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Epilepsy is one of the most common diseases of the nervous system, affecting about 1% of the world's population. The unpredictable nature of the epilepsy seizures deprives the patients and those around them of living a normal life. Therefore, the development of new methods that can help these p...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105899
更新日期：2020-12-17 00:00:00
abstract：BACKGROUND:Atherosclerosis is a degenerative disease of the arterial wall. It results in the formation of progressively growing plaque lesions that can harden and narrow their host arteries. Current computational models of the inflammatory process that govern atherosclerosis growth are reliant on a number of parameters...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105904
更新日期：2020-12-17 00:00:00
abstract：:The impact of a problem based curriculum has been the subject of increasing interest, as evidenced by several recent articles on the subject [1-4]. McMaster was able to design its library to serve a problem-based curriculum, but since there had been no prior experience with such a curriculum, the library was designed ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90110-4
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:T-wave alternans (TWA) is a fluctuation of the ST-T complex occurring on an every-other-beat basis of the surface electrocardiogram (ECG). It has been shown to be an informative risk stratifier for sudden cardiac death, though the lack of gold standard to benchmark detection methods has promote...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.04.005
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Changes in mechano-electrochemical properties of articular cartilage play an essential role in the majority of cartilage diseases. Despite of this importance, the specific effect of each parameter into tissue behavior remains still obscure. Parametric computational modeling of cartilage can pro...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.09.018
更新日期：2015-12-01 00:00:00
abstract：:Image analysis is a rapidly evolving field with growing applications in science and engineering. In cancer research, it has played a key role in advancing techniques of major diagnostic importance, minimising human intervention and providing vital clinical information. Especially in the field of tissue microscopy, the...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2003.07.001
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The technique of tri-cortical pedicle screw (TCPS) has been used to improve the anchoring strength in the sacral vertebrae. However, no studies have reported their application in the thoracic vertebrae. Our research is aimed to assess the stability and strength of the TCPS in thoracic vertebrae...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105035
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To increase the success rate of invasive mechanical ventilation weaning in critically ill patients using Machine Learning models capable of accurately predicting the outcome of programmed extubations. METHODS:The study population was adult patients admitted to the Intensive Care Unit. Target e...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105869
更新日期：2020-11-24 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Virtual reality surgery simulators have been proved effective for training in several surgical disciplines. Nevertheless, this technology is presently underutilized in orthopaedics, especially for bone machining procedures, due to the limited realism in haptic simulation of bone interactions. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105263
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:This paper proposes a novel approach for automatic left ventricle (LV) quantification using convolutional neural networks (CNN). METHODS:The general framework consists of one CNN for detecting the LV, and another for tissue classification. Also, three new deep learning architectures were proposed for LV quan...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.12.002
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Detection and classification of pulmonary nodules are critical tasks in medical image analysis. The Lung Image Database Consortium (LIDC) database is a widely used resource for small pulmonary nodule classification research. This dataset is comprised of nodule characteristic evaluations and CT...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.10.009
更新日期：2018-11-01 00:00:00
abstract：:The microcomputer program presented here allows the simulation of linear compartmental physiological models whose structure is known. The method used is the 4th order Runge-Kutta method. Implemented on the Apple IIe, this program is fully interactive and presents the possibility of changing model parameters or initial...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(87)90066-6
更新日期：1987-02-01 00:00:00
