Abstract：
BACKGROUND AND OBJECTIVE:Changes in mechano-electrochemical properties of articular cartilage play an essential role in the majority of cartilage diseases. Despite of this importance, the specific effect of each parameter into tissue behavior remains still obscure. Parametric computational modeling of cartilage can provide some insights into this matter, specifically the study of mechano-electrochemical properties variation and their correlation with tissue swelling, water and ion fluxes. Thus, the aim of this study is to evaluate the influence of the main mechanical and electrochemical parameters on the determination of articular cartilage behavior by a parametric analysis through a 3D finite element model. METHODS:For this purpose, a previous 3D mechano-electrochemical model, developed by the same authors, of articular cartilage behavior has been used. Young's modulus, Poisson coefficient, ion diffusivities and ion activity coefficients variations have been analyzed and quantified through monitoring tissue simulated response. RESULTS:Simulation results show how Young's modulus and Poisson coefficient control tissue behavior rather than electrochemical properties. Meanwhile, ion diffusivity and ion activity coefficients appear to be vital in controlling velocity of incoming and outgoing fluxes. CONCLUSIONS:This parametric study establishes a basic guide when defining the main properties that are essential to be included into computational modeling of articular cartilage providing a helpful tool in tissue simulations.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Manzano S,Doblaré M,Doweidar MHdoi
10.1016/j.cmpb.2015.09.018subject
Has Abstractpub_date
2015-12-01 00:00:00pages
491-502issue
3eissn
0169-2607issn
1872-7565pii
S0169-2607(15)00245-Xjournal_volume
122pub_type
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journal_title：Computer methods and programs in biomedicine
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